SZGR2 - Beplay体育中心

Summary？

基因	8974
象征	P4HA2
Synonyms	-
Description	脯氨酰4-羟化酶亚基α2
Reference	MIM:600608\|HGNC：HGNC：8547\|Ensembl：ENSG0000000072682\|HPRD:11862\|Vega:OTTHUMG00000059647
基因类型	蛋白质编码
Map location	5Q31
Pascal p-value	0.399
Sherlock p-value	1.018E-4
胎儿β	-0.572
DMG	1(# studies)
主持人	Putamen basal ganglia Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
GSMA_I	Genome scan meta-analysis	PSR：0.0032

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
cg09140281	5	131563492	P4HA2	4.973E-4	-0.366	0.047	DMG：Wockner_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
rs6689013	CHR1	186980817	P4HA2	8974		0.09		反式
RS7607798	CHR2	102043108	P4HA2	8974		0.1		反式
rs1879328	CHR3	46568156	P4HA2	8974		0.18		反式
RS7706288	CHR5	141864248	P4HA2	8974		0.12		反式
RS3899870	CHR13	97205717	P4HA2	8974		0.04		反式
RS9300361	CHR13	97210272	P4HA2	8974		0.05		反式
rs16965683	CHR15	38115683	P4HA2	8974		1.326E-4		反式
RS17283561	Chrx	33355912	P4HA2	8974		0.17		反式
RS5975293	Chrx	130948027	P4HA2	8974		0.18		反式
RS201959459	5	130864001	P4HA2	ENSG0000000072682.14	2.703E-6	0.04	767007	gtex_brain_putamen_basal
rs25884	5	131412238	P4HA2	ENSG0000000072682.14	3.434E-6	0.04	218770	gtex_brain_putamen_basal
rs45236	5	131440620	P4HA2	ENSG0000000072682.14	3.03E-6	0.04	190388	gtex_brain_putamen_basal
RS269900	5	131482244	P4HA2	ENSG0000000072682.14	3.03E-6	0.04	148764	gtex_brain_putamen_basal
RS2550973	5	131511141	P4HA2	ENSG0000000072682.14	3.001E-6	0.04	119867	gtex_brain_putamen_basal
RS201381512	5	131511399	P4HA2	ENSG0000000072682.14	2.009E-6	0.04	119609	gtex_brain_putamen_basal
rs152056	5	131517482	P4HA2	ENSG0000000072682.14	2.662E-6	0.04	113526	gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
AGGF1	0.93	0.93
Rab6a	0.92	0.92
ARMCX3	0.92	0.92
YWHAB	0.91	0.89
Btrc	0.91	0.90
C5orf22	0.90	0.90
Serinc1	0.90	0.90
cltc	0.90	0.90
VPS41	0.90	0.90
UCHL5	0.90	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
FXYD1	-0.63	-0.58
EIF4EBP3	-0.63	-0.66
MT-CO2	-0.62	-0.58
AF347015.21	-0.62	-0.53
HIGD1B	-0.62	-0.59
AF347015.31	-0.61	-0.59
ENHO	-0.61	-0.67
AF347015.2	-0.61	-0.56
TLCD1	-0.60	-0.57
PLA2G5	-0.59	-0.56

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005506	铁离子结合	IEA		-
去：0005515	蛋白质结合	IPI		14667819
去：0004656	Procollagen-丙酸酯4-二加氧酶活性	TAS		9211872
去:0016706	氧化还原酶的活性，作用于配对供体，并掺入或还原分子氧，2-氧基谷氨酸酯作为一个供体，并掺入一个氧气中的一个氧气中	IEA		-
去:0016702	氧化还原酶活性，作用于单个供体，并掺入分子氧，掺入两个原子的氧气	IEA		-
去:0009055	electron carrier activity	TAS		9211872
GO：0016491	氧化还原酶活性	IEA		-
GO：0031418	L-ascorbic acid binding	IEA		-
GO：0046872	metal ion binding	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO：0019538	蛋白质代谢过程	IEA		-
去:0055114	oxidation reduction	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005788	内质网腔	IEA		-
去：0005783	内质网	IEA		-

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
Kegg精氨酸和脯氨酸代谢	54	39	All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤	783	507	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向DN	240	171	All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时	162	116	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP	171	112	All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧	130	85	All SZGR 2.0 genes in this pathway
Elvidge Hif1a靶向DN	91	58	All SZGR 2.0 genes in this pathway
Elvidge HIF1A和HIF2A靶向DN	104	72	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
chebotaev gr目标	77	62	All SZGR 2.0 genes in this pathway
Graessmann血清剥夺DN的细胞凋亡	234	147	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向	769	437	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
布伊泰尔特说光动力治疗压力	811	508	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN	428	306	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
马纳洛缺氧	207	145	All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞	293	193	All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP	89	61	All SZGR 2.0 genes in this pathway
量缺氧	98	71	All SZGR 2.0 genes in this pathway
Traynor Rett综合征DN	19	14	All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向	175	116	All SZGR 2.0 genes in this pathway
伦纳德缺氧	47	35	All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS	36	32	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
西部肾上腺皮质肿瘤	294	199	All SZGR 2.0 genes in this pathway
podar对Apaphostin的反应	147	98	All SZGR 2.0 genes in this pathway
Qi Plasmacytoma dn	100	63	All SZGR 2.0 genes in this pathway
冬季缺氧metagene	242	168	All SZGR 2.0 genes in this pathway
Mootha PGC	420	269	All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN	252	155	All SZGR 2.0 genes in this pathway
Takeer吉西他滨抗性DN	122	84	All SZGR 2.0 genes in this pathway
MILI假足趋化性DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3	349	234	All SZGR 2.0 genes in this pathway
Mikkelsen NPC HCP，带有H3K4ME3和H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
YAO对孕酮簇8的时间反应8	49	36	All SZGR 2.0 genes in this pathway
萨森对促性腺营养蛋白的反应	91	59	All SZGR 2.0 genes in this pathway
Sasson对Forskolin的反应	90	58	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
Qi缺氧	140	96	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN	242	146	All SZGR 2.0 genes in this pathway
Wierenga Stat5A靶向	217	131	All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1	136	76	All SZGR 2.0 genes in this pathway
BMI1和PCGF2的Wiederschain目标	57	39	All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN	882	538	All SZGR 2.0 genes in this pathway
Fardin缺氧11	32	29	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A	770	480	All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38	337	236	All SZGR 2.0 genes in this pathway
NABA ECM监管机构	238	125	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
Let-7/98	266	272	1a	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				HSA-MIR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
miR-124/506	257	263	M8	hsa-miR-506	uaaggcacccuucugugaguaga
miR-124/506	257	263	M8	HSA-MIR-124^brain	UAAGGCACGCGGUGAAUGCC
mir-129-5p	367	373	1a	HSA-MIR-129^brain	cuuuuugcgguggggcuugc
mir-129-5p	367	373	1a	HSA-MIR-129-5p	cuuuuugcgguggggcuugcu
mir-30-5p	320	327	1A，M8	HSA-MIR-30A-5P	uguaaaacauccuccugagaag
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-9	302	308	M8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:P4HA2