Summary?
GeneID 898
Symbol CCNE1
Synonyms CCNE|pCCNE1
Description cyclin E1
Reference MIM:123837|HGNC:HGNC:1589|Ensembl:ENSG00000105173|HPRD:00455|Vega:OTTHUMG00000177626
Gene type protein-coding
Map location 19q12
Pascal p-value 0.276
Fetal beta -1.146
DMG 1 (# studies)
eGene Myers' cis & trans
Meta

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.004

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06636316 19 30303495 CCNE1 1.07的军医 -0.006 0.123 DMG:Montano_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1578978 chr8 118196802 CCNE1 898 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding 新闻学会 9891079
GO:0050681 androgen receptor binding NAS 15572661
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000082 G1/S transition of mitotic cell cycle NAS 8207080
GO:0007049 cell cycle IEA -
GO:0051301 cell division IEA -
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0045893 positive regulation of transcription, DNA-dependent NAS 15572661
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 7799941|11907280
GO:0005634 nucleus NAS -
GO:0005654 nucleoplasm EXP 7629134|10454565

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor - HPRD,BioGRID 10953010
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset Affinity Capture-Western BioGRID 17525332
CABLES1 CABLES | FLJ35924 | HsT2563 | IK3-1 Cdk5 and Abl enzyme substrate 1 - HPRD 11733001
CCT4 CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRB chaperonin containing TCP1, subunit 4 (delta) - HPRD,BioGRID 9819444
CDC2 CDC28A | CDK1 | DKFZp686L20222 | MGC111195 cell division cycle 2, G1 to S and G2 to M - HPRD,BioGRID 1388288
CDC25A CDC25A2 cell division cycle 25 homolog A (S. pombe) - HPRD,BioGRID 8617791
CDK2 p33(CDK2) cyclin-dependent kinase 2 - HPRD,BioGRID 1388288
CDK3 - cyclin-dependent kinase 3 - HPRD,BioGRID 11733001
CDKN1A CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) p21 interacts with cyclin E. BIND 9632134
CDKN1A CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) Affinity Capture-Western BioGRID 12839982
CDKN1A CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A (p21) interacts with CCNE1 (cyclin E). BIND 8662825
CDKN1B CDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) p27 interacts with cyclin E. BIND 9632134
CDKN1B CDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) p27 interacts with Cyc E. BIND 15469821
CDKN1B CDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) Affinity Capture-Western BioGRID 9891079|12529437
COIL CLN80 | p80-coilin coilin - HPRD,BioGRID 10751146
CUL3 - cullin 3 - HPRD,BioGRID 10500095
E2F4 E2F-4 E2F transcription factor 4, p107/p130-binding Affinity Capture-Western BioGRID 9891079
FBXW7 AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10 F-box and WD repeat domain containing 7 Phosphorylated cycE interacts with Fbw7. This interaction was modeled on a demonstrated interaction between cycE from human and Fbw7 from an unspecified species. BIND 14739463
FBXW7 AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10 F-box and WD repeat domain containing 7 - HPRD,BioGRID 11533444|11565033
|14536078
FBXW7 AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10 F-box and WD repeat domain containing 7 hCDC4 interacts with cyclin E. This interaction was modelled on a demonstrated interaction between human CDC4 and cyclin E from an unspecified species. BIND 14999283
GSK3B - glycogen synthase kinase 3 beta Biochemical Activity BioGRID 14536078
HERC5 CEB1 | CEBP1 hect domain and RLD 5 - HPRD,BioGRID 10581175
PARK2 AR-JP | LPRS2 | PDJ | PRKN Parkinson disease (autosomal recessive, juvenile) 2, parkin Affinity Capture-Western BioGRID 12628165
RBL1 CP107 | MGC40006 | PRB1 | p107 retinoblastoma-like 1 (p107) - HPRD 8230483
RBL1 CP107 | MGC40006 | PRB1 | p107 retinoblastoma-like 1 (p107) Affinity Capture-Western BioGRID 9891079
RBL2 FLJ26459 | P130 | Rb2 retinoblastoma-like 2 (p130) - HPRD,BioGRID 8253383
REL C-Rel v-rel reticuloendotheliosis viral oncogene homolog (avian) - HPRD 9731206
RRN3 DKFZp566E104 | MGC104238 | TIFIA RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) Reconstituted Complex BioGRID 15004009
SF3B1 PRP10 | PRPF10 | SAP155 | SF3b155 splicing factor 3b, subunit 1, 155kDa Affinity Capture-Western BioGRID 9891079
SKP2 FBL1 | FBXL1 | FLB1 | MGC1366 S-phase kinase-associated protein 2 (p45) - HPRD,BioGRID 11237742
SMARCA2 BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Affinity Capture-Western BioGRID 9891079
SMARCA4 BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 - HPRD,BioGRID 9891079
SMARCB1 BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Affinity Capture-Western BioGRID 9891079
SMARCC1 BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 - HPRD,BioGRID 9891079


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY 69 45 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
BIOCARTA MCM PATHWAY 18 8 All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY 28 21 All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA SKP2E2F PATHWAY 10 6 All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY 26 23 All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY 16 13 All SZGR 2.0 genes in this pathway
BIOCARTA P27 PATHWAY 13 10 All SZGR 2.0 genes in this pathway
SA REG CASCADE OF CYCLIN EXPR 13 7 All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 23 17 All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 74 48 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY 29 19 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1 25 13 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 57 35 All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 35 17 All SZGR 2.0 genes in this pathway
REACTOME G1 S SPECIFIC TRANSCRIPTION 19 9 All SZGR 2.0 genes in this pathway
REACTOME S PHASE 109 66 All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 56 34 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 87 49 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
林格伦膀胱癌集群1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 69 40 All SZGR 2.0 genes in this pathway
NUNODA反应达沙替尼伊马替尼 29 20 All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS UP 23 15 All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 97 58 All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT5 TARGETS 7 7 All SZGR 2.0 genes in this pathway
LI LUNG CANCER 41 30 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
HONRADO BREAST CANCER BRCA1 VS BRCA2 18 12 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP 48 23 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 66 38 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 64 41 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 IN LIVER CANCER UP 8 7 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 29 20 All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS DN 21 15 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 57 35 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 66 48 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 All SZGR 2.0 genes in this pathway
NUMATA CSF3 SIGNALING VIA STAT3 22 17 All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 70 47 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP 27 19 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 60 42 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS UP 24 14 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 115 80 All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS 19 16 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A DN 18 7 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN DN 18 16 All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP 25 22 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 142 79 All SZGR 2.0 genes in this pathway
霍夫曼LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS 53 27 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 75 43 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 66 38 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 44 25 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 147 76 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 211 217 m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-15/16/195/424/497 247 254 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-26 265 271 m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-503 486 492 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
miR-9 18 25 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA