Gene Page:hap1

Summary？
基因 9001
象征 hap1
Synonyms HAP2|HIP5|HLP|hHLP1
Description 亨廷顿相关蛋白1
Reference MIM：600947|HGNC：HGNC：4812|ENSEMBL：ENSG00000173805|HPRD：02972|Vega:OTTHUMG00000133498
基因类型 蛋白质编码
Map location 17Q21.2-Q21.3
Pascal p-value 0.674
Sherlock p-value 0.128
胎儿β -0.604
主持人 元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0229

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
LRIG3 0.78 0.31
COL4A6 0.77 0.50
boc 0.77 0.35
SOX3 0.75 0.32
NHLH1 0.75 0.40
MFAP2 0.74 0.43
TNFRSF19 0.74 0.47
VIM 0.74 0.42
GPC4 0.73 0.38
jub 0.72 0.35
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
C5orf53 -0.33 -0.34
AF347015.27 -0.31 -0.37
LGI4 -0.30 -0.23
AF347015.33 -0.30 -0.36
AC131097.1 -0.30 -0.38
AF347015.31 -0.29 -0.33
HLA-F -0.29 -0.26
AF347015.8 -0.29 -0.35
MT-CO2 -0.29 -0.35
AIFM3 -0.28 -0.25

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0003674 Molecular_Function nd -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007268 synaptic transmission TAS 神经元，突触，神经递质（GO期限：6） 9361024
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0015629 肌动蛋白细胞骨架 TAS 9361024

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ATP5J2 ATP5JL ATP合酶，H+转运，线粒体F0复合物，亚基F2 Two-hybrid Biogrid 16169070
BRD7 BP75 |Celtix1 |Nag4 含有7的溴结构域 - HPRD 15383276
C15orf29 FLJ22557 |MGC117356 染色体15开放阅读框29 Two-hybrid Biogrid 16169070
C8orf33 FLJ20989 染色体8开放阅读框33 Two-hybrid Biogrid 16169070
CBX8 HPC3 |PC3 |RC1 chromobox homolog 8 (Pc class homolog, Drosophila) Two-hybrid Biogrid 16169070
CCDC113 DKFZP434N1418 |FLJ23555 |HSPC065 coiled-coil domain containing 113 Two-hybrid Biogrid 16169070
CDK5RAP2 C48 |CEP215 |DKFZP686B1070 |DKFZP686D1070 |KIAA1633 |MCPH3 CDK5调节亚基相关蛋白2 Two-hybrid Biogrid 16169070
COL9A2 DJ39G22.4 |EDM2 |医学 胶原蛋白，IX型，Alpha 2 Two-hybrid Biogrid 16169070
CRIP1 CRHP |crip |CRP1 |FLJ40971 富含半胱氨酸的蛋白1（肠道） Two-hybrid Biogrid 16169070
DCTN1 DAP-150 |DP-150 |HMN7B |P135 Dynactin 1（P150，胶合同源物，果蝇） - HPRD,BioGRID 9361024|9454836
DDX49 FLJ10432 |R27090_2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 Two-hybrid Biogrid 16169070
EIF3E EIF3-P48 |EIF3S6 |int6 |EIF3-P46 真核翻译起始因子3，亚基E Two-hybrid Biogrid 16169070
FAM173A C16orf24 | MGC2494 family with sequence similarity 173, member A Two-hybrid Biogrid 16169070
GLTSCR2 Pict-1 |Pict1 glioma tumor suppressor candidate region gene 2 Two-hybrid Biogrid 16169070
hap1 hap2 |hip5 |HLP |HHLP1 亨廷顿相关蛋白1 - HPRD,BioGRID 9798945
HGS HRS |ZFYVE8 肝细胞生长factor-regulated酪氨酸激酶substrate - HPRD,BioGRID 12021262
HMOX2 HO-2 heme oxygenase (decycling) 2 Two-hybrid Biogrid 16169070
htt 高清|IT15 huntingtin 亲和力捕获 - 韦斯特恩
体外
in vivo
重构的复合物
Two-hybrid		 Biogrid 7477378|9454836
|9599014|9668110
htt 高清|IT15 huntingtin HTT与HAP1相互作用。这种相互作用是根据人类HTT和大鼠HAP1之间的相互作用进行建模的。 绑定 15654337
htt 高清|IT15 huntingtin Huntingtin interacts with HAP1. 绑定 9668110
htt 高清|IT15 huntingtin Htt interacts with Hap1. 绑定 7477378
htt 高清|IT15 huntingtin - HPRD 7477378|9599014
|9668110|10974549
MPP3 DLG3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) Two-hybrid Biogrid 16169070
MRPS9 MRP-S9 |rpms9 |S9MT 线粒体核糖体蛋白S9 Two-hybrid Biogrid 16169070
NAP1L5 DRLM 核小体组装蛋白1类样5 Two-hybrid Biogrid 16169070
NDUFB9 B22 |DKFZP566O173 |FLJ22885 |lyrm3 |UQOR22 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa Two-hybrid Biogrid 16169070
Neurod1 beta2 |BHF-1 |Neurod |BHLHA3 neurogenic differentiation 1 - HPRD,BioGRID 12881483
NIPSNAP3A DKFZp564D177 | FLJ13953 | HSPC299 | MGC14553 | NIPSNAP4 | TASSC nipsnap homolog 3A (C. elegans) Two-hybrid Biogrid 16169070
PCM1 PTC4 丁香三醇材料1 - HPRD,BioGRID 9361024
PDCD7 ES18 |Hes18 |MGC22015 程序性细胞死亡7 Two-hybrid Biogrid 16169070
PFDN1 PDF | PFD1 prefoldin subunit 1 Two-hybrid Biogrid 16169070
PPID CYP-40 | CYPD | MGC33096 肽基丙基异构酶d Two-hybrid Biogrid 16169070
PPOX MGC8485 |PPO |v290m |VP 原核原氧化酶 Two-hybrid Biogrid 16169070
PSMD11 MGC3844 | Rpn6 | S9 | p44.5 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，11 Two-hybrid Biogrid 16169070
RER1 - RER1在内质网中保留1同源物（S. cerevisiae） Two-hybrid Biogrid 16169070
RPS10 MGC88819 核糖体蛋白S10 Two-hybrid Biogrid 16169070
RPS25 - ribosomal protein S25 Two-hybrid Biogrid 16169070
SFRS4 SRP75 splicing factor, arginine/serine-rich 4 Two-hybrid Biogrid 16169070
Snapin SNAPAP 快速相关的蛋白质 Two-hybrid Biogrid 16169070
STX5 sed5 |STX5A syntaxin 5 Two-hybrid Biogrid 16169070
TAF1D josd3 |MGC5306 |taf（i）41 TATA盒结合蛋白（TBP）相关因子，RNA聚合酶I，D，41KDA Two-hybrid Biogrid 16169070
TNNT3 AMCD2B | DA2B | DKFZp779M2348 | FSSV 肌钙蛋白T型3（骨骼，快速） Two-hybrid Biogrid 16169070
TOMM20 KIAA0016 | MAS20 | MGC117367 | MOM19 | TOM20 线粒体外膜20同源物（酵母）的易位酶 Two-hybrid Biogrid 16169070
tspyl1 tspyl TSPY-like 1 Two-hybrid Biogrid 16169070
UTP3 CRL1 |crlz1 |FLJ23256 |SAS10 UTP3，小亚基（SSU）Processome组件，同源物（S. cerevisiae） Two-hybrid Biogrid 16169070
ZNF20 FLJ39241 |KOX13 锌指蛋白20 Two-hybrid Biogrid 16169070
ZNF24 kox17 |RSG-A |Znf191 |ZSCAN3 |ZFP191 锌指蛋白24 Two-hybrid Biogrid 16169070
ZNF691 RP11-342M1.5 |ZFP691 锌指蛋白691 Two-hybrid Biogrid 16169070


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG HUNTINGTONS DISEASE 185 109 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
LI LUNG CANCER 41 30 All SZGR 2.0 genes in this pathway
Benporath Suz12目标 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN 57 39 All SZGR 2.0 genes in this pathway
Lein Midbrain标记 82 55 All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER UP 92 45 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
Yagi AML带有Inv 16易位 422 277 All SZGR 2.0 genes in this pathway
Asgharzadeh神经母细胞瘤生存率差DN 46 30 All SZGR 2.0 genes in this pathway
双龙雷帕霉素敏感基因 39 20 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-328 405 411 M8 hsa-miR-328brain cuggcccucugccuuccgu
mir-339 402 408 M8 hsa-miR-339 ucccuccuccaggagcuca