Gene Page:TAF1C

Summary?
GeneID 9013
Symbol TAF1C
Synonyms MGC:39976|SL1|TAFI110|TAFI95
Description TATA-box binding protein associated factor, RNA polymerase I subunit C
Reference MIM:604905|HGNC:HGNC:11534|Ensembl:ENSG00000103168|HPRD:05364|Vega:OTTHUMG00000176665
Gene type protein-coding
Map location 16q24
Pascal p-value 0.743
Sherlock p-value 0.602
Fetal beta 0.983
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
元
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
TAF1C chr16 84213434 A T NM_001243156
NM_001243157
NM_001243158
NM_001243159
NM_001243160
NM_005679
NM_139353		 p.549L>M
p.243L>M
p.243L>M
p.166L>M
p.98L>M
p.575L>M
p.481L>M		 missense
missense
missense
missense
missense
missense
missense		 Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2081247 chr16 84221961 TAF1C 9013 0.1 cis
rs4489992 16 84206843 TAF1C ENSG00000103168.12 1.398E-7 0 13826 gtex_brain_putamen_basal
rs3803643 16 84208032 TAF1C ENSG00000103168.12 1.164E-8 0 12637 gtex_brain_putamen_basal
rs3803642 16 84208144 TAF1C ENSG00000103168.12 1.122E-8 0 12525 gtex_brain_putamen_basal
rs12597741 16 84208667 TAF1C ENSG00000103168.12 7.822E-8 0 12002 gtex_brain_putamen_basal
rs12597782 16 84208891 TAF1C ENSG00000103168.12 8.053E-8 0 11778 gtex_brain_putamen_basal
rs34693209 16 84209138 TAF1C ENSG00000103168.12 1.161E-8 0 11531 gtex_brain_putamen_basal
rs2288019 16 84209634 TAF1C ENSG00000103168.12 5.422 e - 0 11035 gtex_brain_putamen_basal
rs3743637 16 84210172 TAF1C ENSG00000103168.12 5.573E-7 0 10497 gtex_brain_putamen_basal
rs11149630 16 84210749 TAF1C ENSG00000103168.12 5.452E-7 0 9920 gtex_brain_putamen_basal
rs8692 16 84211483 TAF1C ENSG00000103168.12 5.184E-7 0 9186 gtex_brain_putamen_basal
rs2278043 16 84213965 TAF1C ENSG00000103168.12 2.613E-9 0 6704 gtex_brain_putamen_basal
rs2303234 16 84214837 TAF1C ENSG00000103168.12 1.415E-7 0 5832 gtex_brain_putamen_basal
rs3815814 16 84215314 TAF1C ENSG00000103168.12 1.486E-7 0 5355 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DDX49 0.95 0.95
PRMT1 0.93 0.95
EIF6 0.93 0.93
RUVBL2 0.92 0.94
CECR5 0.92 0.93
CFL1 0.91 0.92
ARMC6 0.91 0.94
EBP 0.91 0.93
ACTL6B 0.91 0.92
WDR74 0.91 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.33 -0.75 -0.83
AF347015.27 -0.75 -0.82
AF347015.8 -0.74 -0.82
MT-CO2 -0.74 -0.79
AF347015.31 -0.74 -0.80
MT-CYB -0.74 -0.82
AF347015.15 -0.73 -0.82
AF347015.2 -0.72 -0.83
AF347015.26 -0.70 -0.82
AF347015.9 -0.67 -0.78

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME RNA POL I TRANSCRIPTION TERMINATION 22 12 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 89 64 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 122 80 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 25 14 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 48 31 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY 4NQO IN OLD 13 10 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY 4NQO IN WS 40 26 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN OLD 31 19 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 33 22 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY UV IN OLD 25 18 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY UV IN WS 12 9 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 56 41 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG UP 41 26 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway