Gene Page:CCNT1

概括?
基因 904
象征 CCNT1
Synonyms CCNT|CYCT1|HIVE1
Description cyclin T1
Reference MIM:143055|HGNC：HGNC：1599|Ensembl:ENSG00000129315|HPRD:03938|Vega:OTTHUMG00000170393
Gene type protein-coding
Map location 12q13.11
Pascal p-value 0.386
Sherlock p-value 0.562
Fetal beta 0.954
DMG 1 (# studies)
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
Expression Meta-analysis of gene expression Pvalue: 1.606

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg22103585 12 49110427 CCNT1 -0.032 0.46 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9637082 chr21 21213235 CCNT1 904 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IDA 16109376
GO:0005515 protein binding IPI 12944466
GO:0017069 snRNA binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0000079 监管cyclin-dependent protein kinase activity TAS 9499409
去：0006355 regulation of transcription, DNA-dependent IEA -
去：0006350 transcription IEA -
去：0006468 protein amino acid phosphorylation IPI 16109376
GO:0006366 transcription from RNA polymerase II promoter TAS 9499409
GO:0007049 cell cycle IEA -
GO:0051301 cell division IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 12944466
GO:0005654 核质 经验 7853496|12676794
GO:0005730 nucleolus IDA 16109376

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental 资源 PubMed ID
AFF4 AF5Q31 | MCEF | MGC75036 AF4/FMR2 family, member 4 - HPRD,BioGRID 12065898
AHR - aryl hydrocarbon receptor - HPRD,BioGRID 12917420
CCNK CPR4 | MGC9113 cyclin K in vitro
in vivo		 BioGRID 10574912
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 - HPRD 9872325|10465067
|10617616|11145967
|11689688|11713532
|11713533|12115727
|12894230|14627702
|15528190
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 CyclinT1 interacts with Cdk9. BIND 9499409
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 CycT1 interacts with CDK9. This interaction was modeled on a demonstrated interaction between CycT1 from an unspecified species and human CDK9. BIND 15546612
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 Affinity Capture-Western
in vitro
in vivo
Phenotypic Suppression
Reconstituted Complex
两个杂交		 BioGRID 9499409|10656684
|10958691|11689688
|12588988|12832472
|12944466|15107825
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 Cyclin T1与CDK9相互作用。 BIND 12588988
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 - HPRD 9499409|10958691
GRIPAP1 DKFZP434P0630 |grasp-1 |KIAA1167 |MGC126593 |MGC126595 GRIP1相关蛋白1 in vitro
in vivo		 BioGRID 11704662
GRN GEP |GP88 |PCDGF |pepi |PGRN 颗粒蛋白 - HPRD,BioGRID 12588988
GRN GEP |GP88 |PCDGF |pepi |PGRN 颗粒蛋白 Cyclin T1 interacts with granulin. BIND 12588988
HEXIM1 CLP1 | EDG1 | FLJ13562 | HIS1 | MAQ1 hexamethylene bis-acetamide inducible 1 - HPRD,BioGRID 12832472
HTATSF1 TAT-SF1 | dJ196E23.2 HIV-1特异性因子1 - HPRD,BioGRID 10913173|11780068
MDFIC HIC MyoD family inhibitor domain containing Affinity Capture-Western
Reconstituted Complex
两个杂交		 BioGRID 12944466
MYBL2 B-myb |bmyb |MGC15600 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 Phenotypic Suppression BioGRID 10656684
MYC bHLHe39 | c-Myc v-myc myelocytomatosis viral oncogene homolog (avian) - HPRD,BioGRID 12944920
NCOA2 GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2 nuclear receptor coactivator 2 Cyclin T1与GRIP1相互作用。 BIND 11704662
NUFIP1 NUFIP | bA540M5.1 nuclear fragile X mental retardation protein interacting protein 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 15107825
NUFIP1 NUFIP | bA540M5.1 nuclear fragile X mental retardation protein interacting protein 1 CyclinT1 interacts with NUFIP. BIND 15107825
PML myl |pp8675 |RNF71 |TRIM19 Promyelocytic白血病 - HPRD,BioGRID 12727882
PURA PUR-ALPHA | PUR1 | PURALPHA purine-rich element binding protein A - HPRD,BioGRID 11730934
SKP2 FBL1 | FBXL1 | FLB1 | MGC1366 S-phase kinase-associated protein 2 (p45) - HPRD 11689688


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 27 17 该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 38 26 该途径中的所有SZGR 2.0基因
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 该途径中的所有SZGR 2.0基因
Reactome RNA Pol II转录 105 54 该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTION 210 127 该途径中的所有SZGR 2.0基因
RNA Pol II伸长复合物的反应组形成 45 19 该途径中的所有SZGR 2.0基因
REACTOME ELONGATION ARREST AND RECOVERY 32 14 该途径中的所有SZGR 2.0基因
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 61 32 该途径中的所有SZGR 2.0基因
REACTOME HIV INFECTION 207 122 该途径中的所有SZGR 2.0基因
REACTOME HIV LIFE CYCLE 125 69 该途径中的所有SZGR 2.0基因
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 该途径中的所有SZGR 2.0基因
REACTOME LATE PHASE OF HIV LIFE CYCLE 104 61 该途径中的所有SZGR 2.0基因
TGFβ受体复合物的反应组信号传导 63 42 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
NOUZOVA TRETINOIN AND H4 ACETYLATION 143 85 该途径中的所有SZGR 2.0基因
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 该途径中的所有SZGR 2.0基因
MAHAJAN RESPONSE TO IL1A UP 81 52 该途径中的所有SZGR 2.0基因
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 该途径中的所有SZGR 2.0基因
WHITEFORD PEDIATRIC CANCER MARKERS 116 63 该途径中的所有SZGR 2.0基因
LABBE TGFB1 TARGETS DN 108 64 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS UP 504 321 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE MIDDLE 98 56 该途径中的所有SZGR 2.0基因
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 该途径中的所有SZGR 2.0基因
KOHOUTEK CCNT1 TARGETS 50 26 该途径中的所有SZGR 2.0基因
LE NEURONAL DIFFERENTIATION DN 19 16 该途径中的所有SZGR 2.0基因
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 该途径中的所有SZGR 2.0基因