Gene Page:SHF

Summary?
GeneID 90525
Symbol SHF
Synonyms -
Description Src homology 2 domain containing F
Reference HGNC:HGNC:25116|Ensembl:ENSG00000138606|HPRD:14272|Vega:OTTHUMG00000131353
Gene type protein-coding
Map location 15q21.1
Pascal p-value 0.882
Fetal beta 0.952
DMG 2 (# studies)
eGene Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01908020 15 45494784 SHF 3.802E-4 -0.255 0.043 DMG:Wockner_2014
cg20696985 15 45480429 SHF 2.98E-9 -0.014 2.08E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6687849 chr1 175904808 SHF 90525 0.08 trans
rs2481653 chr1 176044120 SHF 90525 0.16 trans
rs2502827 chr1 176044216 SHF 90525 0.02 trans
rs17572651 chr1 218943612 SHF 90525 0 trans
rs6543365 0 SHF 90525 0.08 trans
rs16829545 chr2 151977407 SHF 90525 7.832E-21 trans
rs3845734 chr2 171125572 SHF 90525 0 trans
rs7584986 chr2 184111432 SHF 90525 4.175E-9 trans
rs6741060 chr2 217169088 SHF 90525 0.15 trans
rs3732634 chr3 58104876 SHF 90525 0.13 trans
rs2183142 chr4 159232695 SHF 90525 0.04 trans
rs170776 chr4 173276735 SHF 90525 0.11 trans
rs1396222 chr4 173279496 SHF 90525 0.07 trans
rs335993 chr4 173321789 SHF 90525 0.16 trans
rs335980 chr4 173329784 SHF 90525 0.06 trans
rs335982 chr4 173330945 SHF 90525 0.14 trans
rs337984 chr4 173411662 SHF 90525 0.17 trans
rs17762315 chr5 76807576 SHF 90525 2.006E-4 trans
rs17583830 chr6 107778357 SHF 90525 0.18 trans
rs7787830 chr7 98797019 SHF 90525 0.08 trans
rs11139334 chr9 84209393 SHF 90525 0.04 trans
rs11061703 chr12 1436977 SHF 90525 0.05 trans
rs16955618 chr15 29937543 SHF 90525 2.157E-32 trans
rs11873184 chr18 1584081 SHF 90525 0.05 trans
rs1041786 chr21 22617710 SHF 90525 0.01 trans
rs17404243 chr22 26970901 SHF 90525 0.18 trans
rs16986332 chrX 10958354 SHF 90525 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID PDGFRA PATHWAY 22 18 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 126 84 All SZGR 2.0 genes in this pathway
阿塞维多在肝脏通过甲基化R DN 940 425 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway