Gene Page:SLC7A6

Summary?
GeneID 9057
Symbol SLC7A6
Synonyms LAT-2|LAT3|y+LAT-2
Description solute carrier family 7 member 6
Reference MIM:605641|HGNC:HGNC:11064|Ensembl:ENSG00000103064|HPRD:12031|Vega:OTTHUMG00000176544
Gene type protein-coding
Map location 16q22.1
Pascal p-value 4.873E-6
Sherlock p-value 0.351
Fetal beta 1.036
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
SLC7A6 chr16 68330536 G A NM_001076785
NM_003983		 p.426V>M
p.426V>M		 missense
missense		 Schizophrenia DNM:Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg22328890 16 68298258 SLC7A6 -0.027 0.42 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6753473 chr2 26526418 SLC7A6 9057 0.14 trans
rs16829545 chr2 151977407 SLC7A6 9057 6.436E-10 trans
rs7584986 chr2 184111432 SLC7A6 9057 0.18 trans
rs16955618 chr15 29937543 SLC7A6 9057 1.931E-7 trans
rs6032295 chr20 44178138 SLC7A6 9057 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某羊乳酪l (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GTF3C1 0.89 0.88
DAGLB 0.88 0.87
PEX5 0.88 0.89
SLC25A25 0.88 0.90
BSDC1 0.88 0.87
FBXL14 0.88 0.88
USP19 0.88 0.87
IGHMBP2 0.88 0.87
MBD1 0.87 0.87
DHX30 0.87 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.74 -0.76
AF347015.21 -0.74 -0.80
MT-CO2 -0.73 -0.75
AF347015.8 -0.71 -0.74
FXYD1 -0.71 -0.73
AF347015.33 -0.71 -0.72
HIGD1B -0.70 -0.72
AF347015.27 -0.69 -0.73
C1orf54 -0.69 -0.79
MT-CYB -0.69 -0.71

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 30 23 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 31 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 49 36 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN 167 100 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 146 94 All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS UP 67 40 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
OZEN MIR125B1 TARGETS 25 15 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP 44 30 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2 72 52 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR 39 31 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8 40 29 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 42 29 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387 225 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 146 88 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 166 97 All SZGR 2.0 genes in this pathway