Gene Page:MAP3K6

Summary?
GeneID 9064
Symbol MAP3K6
Synonyms ASK2|MAPKKK6|MEKK6
Description mitogen-activated protein kinase kinase kinase 6
Reference MIM:604468|HGNC:HGNC:6858|Ensembl:ENSG00000142733|HPRD:05126|Vega:OTTHUMG00000004631
Gene type protein-coding
Map location 1p36.11
Pascal p-value 0.435
Sherlock p-value 0.839
Fetal beta -0.629
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg11705208 1 27683386 MAP3K6 2.39E-5 0.379 0.017 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6753548 chr2 2268763 MAP3K6 9064 0.14 trans
rs16829545 chr2 151977407 MAP3K6 9064 3.549E-5 trans
rs16955618 chr15 29937543 MAP3K6 9064 2.919E-7 trans
rs11873184 chr18 1584081 MAP3K6 9064 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NARG1 0.96 0.97
SERBP1 0.95 0.94
TOP1 0.95 0.97
WDR3 0.95 0.96
SMEK2 0.95 0.96
SUPT16H 0.95 0.97
ZMYM4 0.95 0.96
BCLAF1 0.95 0.97
PPP2R5E 0.95 0.95
CSGALNACT2 0.95 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.70 -0.87
FXYD1 -0.70 -0.88
MT-CO2 -0.69 -0.88
IFI27 -0.69 -0.87
HLA-F -0.69 -0.76
TSC22D4 -0.68 -0.80
C5orf53 -0.68 -0.73
AF347015.27 -0.68 -0.84
AIFM3 -0.68 -0.76
AF347015.33 -0.68 -0.83

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 26 21 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2 72 52 All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206 117 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS UP 40 25 All SZGR 2.0 genes in this pathway
SHEDDEN肺癌好生存A4 196 124 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162 103 All SZGR 2.0 genes in this pathway