Gene Page:ASH2L

Summary?
GeneID 9070
Symbol ASH2L
Synonyms ASH2|ASH2L1|ASH2L2|Bre2
Description ash2 (absent, small, or homeotic)-like (Drosophila)
Reference MIM:604782|HGNC:HGNC:744|Ensembl:ENSG00000129691|HPRD:05309|Vega:OTTHUMG00000164016
Gene type protein-coding
Map location 8p11.2
Pascal p-value 1.842E-5
Sherlock p-value 0.241
Fetal beta -0.083
DMG 1 (# studies)
eGene Myers' cis & trans
Support Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-occ基因urring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03024183 8 37963317 ASH2L 2.26E-7 -0.311 0.005 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7132043 chr12 80968399 ASH2L 9070 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATRNL1 0.90 0.87
CACNB4 0.89 0.82
FAM126B 0.89 0.87
GABRB2 0.88 0.75
SORL1 0.87 0.80
UBR3 0.87 0.88
TTC39B 0.87 0.78
ARFGEF2 0.86 0.83
CHM 0.86 0.84
CPEB3 0.86 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EFEMP2 -0.50 -0.60
RAB34 -0.48 -0.64
GATSL3 -0.44 -0.55
RHOC -0.43 -0.61
DBI -0.43 -0.60
NKAIN4 -0.41 -0.55
C19orf36 -0.41 -0.53
NUDT8 -0.40 -0.49
C1orf61 -0.40 -0.67
VEGFB -0.39 -0.49

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ASH2L ASH2 | ASH2L1 | ASH2L2 | Bre2 ash2 (absent, small, or homeotic)-like (Drosophila) Reconstituted Complex BioGRID 15199122
DPY30 HDPY-30 | Saf19 dpy-30 homolog (C. elegans) Two-hybrid BioGRID 16189514
HCFC1 CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAF host cell factor C1 (VP16-accessory protein) Reconstituted Complex BioGRID 15199122
HCFC2 FLJ94012 | HCF-2 | HCF2 host cell factor C2 Reconstituted Complex BioGRID 15199122
HIST3H3 H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888 histone cluster 3, H3 Reconstituted Complex BioGRID 12482968
MEN1 MEAI | SCG2 multiple endocrine neoplasia I Reconstituted Complex BioGRID 15199122
MLL ALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) Affinity Capture-Western
Co-purification		 BioGRID 15199122
MLL3 DKFZp686C08112 | FLJ12625 | FLJ38309 | HALR | KIAA1506 | KMT2C | MGC119851 | MGC119852 | MGC119853 myeloid/lymphoid or mixed-lineage leukemia 3 Reconstituted Complex BioGRID 12482968
RBBP5 RBQ3 | SWD1 retinoblastoma binding protein 5 Reconstituted Complex BioGRID 15199122
UNC119 HRG4 unc-119 homolog (C. elegans) Two-hybrid BioGRID 16169070
WDR5 BIG-3 | SWD3 WD repeat domain 5 Reconstituted Complex BioGRID 15199122


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 40 24 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 57 32 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE UP 11 8 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway