Gene Page:DIRAS3

Summary?
GeneID 9077
Symbol DIRAS3
Synonyms ARHI|NOEY2
Description DIRAS family GTP binding RAS like 3
Reference MIM:605193|HGNC:HGNC:687|Ensembl:ENSG00000162595|HPRD:05547|
Gene type protein-coding
Map location 1p31
Pascal p-value 0.145
Fetal beta -0.274
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02692

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21808053 1 68513063 DIRAS3 4.84E-5 -0.372 0.021 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7838399 chr8 8457079 DIRAS3 9077 0.18 trans
rs510992 chr18 24268491 DIRAS3 9077 0.14 trans
rs506038 chr18 24271081 DIRAS3 9077 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
INPP4A 0.94 0.95
MTMR9 0.92 0.95
ABI2 0.92 0.94
ARHGEF7 0.92 0.94
YWHAG 0.92 0.93
MAPRE2 0.92 0.93
GABRB3 0.91 0.94
MAP2 0.91 0.93
PAFAH1B1 0.91 0.92
DLG3 0.90 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.72 -0.74
SLC25A18 -0.69 -0.71
TLCD1 -0.69 -0.73
HSD17B14 -0.68 -0.72
AF347015.31 -0.68 -0.74
MT-CO2 -0.68 -0.74
CLDN10 -0.68 -0.70
HIGD1B -0.68 -0.74
TSC22D4 -0.67 -0.69
AC021016.1 -0.67 -0.72

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003924 GTPase activity TAS 9874798
GO:0005525 GTP binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0000079 细胞周期蛋白依赖性蛋白激酶的监管活动vity TAS 9874798
GO:0006349 genetic imprinting TAS 9874798
GO:0007264 small GTPase mediated signal transduction TAS 9874798
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
PIEPOLI LGI1 TARGETS UP 15 11 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 123 80 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway