Gene Page:NMI
概括?
| 基因 | 9111 |
| 象征 | NMI |
| Synonyms | - |
| Description | N-myc and STAT interactor |
| Reference | MIM:603525|HGNC:HGNC:7854|ENSEMBL：ENSG00000123609|HPRD:04632|Vega:OTTHUMG00000131867 |
| Gene type | protein-coding |
| Map location | 2q23 |
| Pascal p-value | 0.214 |
| Fetal beta | -1.321 |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.02395 | |
| 文学 | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizotypy,schizophrenias,schizotypal | Click to show details |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| 分子功能 | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003712 | transcription cofactor activity | 塔斯 | 10779520 | |
| GO:0005515 | protein binding | IPI | 10597290 | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0006366 | transcription from RNA polymerase II promoter | 塔斯 | 9989503 | |
| GO:0007259 | Jak-Stat Cascade | 塔斯 | 10597290 | |
| GO:0006954 | inflammatory response | 塔斯 | 9989503 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IDA | 18029348 | |
| GO:0005737 | 细胞质 | IDA | 10597290 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 11916966 |
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | BRCA1 interacts with Nmi. | BIND | 11916966 |
| Emilin1 | DKFZp586M121 | EMILIN | EMILIN-1 | gp115 | 弹性蛋白微纤维互面膜1 | 两个杂交 | BioGRID | 16189514 |
| GCSH | GCE | NKH | glycine cleavage system protein H (aminomethyl carrier) | 两个杂交 | BioGRID | 16189514 |
| HDDC3 | MGC45386 | HD domain containing 3 | 两个杂交 | BioGRID | 16189514 |
| HGS | HRS | ZFYVE8 | hepatocyte growth factor-regulated tyrosine kinase substrate | 两个杂交 | BioGRID | 16189514 |
| HHLA3 | - | HERV-H LTR-associating 3 | Affinity Capture-Western 两个杂交 |
BioGRID | 16189514 |
| IFI35 | FLJ21753 | IFP35 | interferon-induced protein 35 | - | HPRD,BioGRID | 10950963 |
| IFI35 | FLJ21753 | IFP35 | interferon-induced protein 35 | Nmi and IFP 35 associate into a high molecular mass complex (HMMC). | BIND | 10950963 |
| LSM4 | YER112W | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | - | HPRD,BioGRID | 15231747 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | - | HPRD | 8668343 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11916966 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | MYC与NMI互动 | BIND | 11916966 |
| MYCN | 模拟|n-myc |NMYC |ODED |Bhlhe37 | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | - | HPRD | 8668343 |
| NECAP2 | FLJ10420 |RP4-798A10.1 | Necap内吞作用相关2 | 两个杂交 | BioGRID | 16189514 |
| NMI | - | N-MYC（和STAT）交互器 | Nmi homodimerizes to form a complex | BIND | 11916966 |
| PSMA1 | HC2 |MGC14542 |MGC14575 |MGC14751 |MGC1667 |MGC21459 |MGC22853 |MGC23915 |nu |PROS30 | proteasome (prosome, macropain) subunit, alpha type, 1 | 两个杂交 | BioGRID | 16189514 |
| SNAPC5 | SNAP19 | small nuclear RNA activating complex, polypeptide 5, 19kDa | 两个杂交 | BioGRID | 16189514 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD,BioGRID | 9989503 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | Nmi interacts with Stat1 | BIND | 9989503 |
| STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | Nmi interacts with Stat3 | BIND | 9989503 |
| STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | - | HPRD,BioGRID | 9989503 |
| STAT4 | SLEB11 | 信号换能器和转录激活因子4 | NMI与STAT4相互作用。这种相互作用是基于未指定物种与人NMI的STAT4之间的相互作用建模的。 | BIND | 9989503 |
| STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | NMI与STAT5A互动 | BIND | 9989503 |
| STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | - | HPRD,BioGRID | 9989503 |
| STAT5B | STAT5 | signal transducer and activator of transcription 5B | NMI与STAT5B互动 | BIND | 9989503 |
| STAT5B | STAT5 | signal transducer and activator of transcription 5B | - | HPRD,BioGRID | 9989503 |
| STAT6 | D12S1644 | IL-4-STAT | STAT6B | STAT6C | 转录6，白介素4的信号换能器和激活剂诱导 | Nmi interacts with Stat6 | BIND | 9989503 |
| TUBA3C | tuba2 |BA408E5.3 | tubulin, alpha 3c | Affinity Capture-Western 两个杂交 |
BioGRID | 16189514 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA IL2RB PATHWAY | 38 | 26 | 该途径中的所有SZGR 2.0基因 |
| Biocarta IL7途径 | 17 | 14 | 该途径中的所有SZGR 2.0基因 |
| Fulcher炎症反应凝集素与LPS DN | 463 | 290 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| LIU VMYB TARGETS UP | 127 | 78 | 该途径中的所有SZGR 2.0基因 |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | 该途径中的所有SZGR 2.0基因 |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | 该途径中的所有SZGR 2.0基因 |
| PROVENZANI METASTASIS DN | 136 | 94 | 该途径中的所有SZGR 2.0基因 |
| ENK UV响应角质形成细胞DN | 485 | 334 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | 该途径中的所有SZGR 2.0基因 |
| OUELLET OVARIAN CANCER INVASIVE VS LMP UP | 117 | 85 | 该途径中的所有SZGR 2.0基因 |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | 该途径中的所有SZGR 2.0基因 |
| korkola蛋黄囊肿瘤 | 62 | 33 | 该途径中的所有SZGR 2.0基因 |
| MOHANKUMAR TLX1 TARGETS DN | 193 | 112 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | 该途径中的所有SZGR 2.0基因 |
| Benporath增殖 | 147 | 80 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH ES CORE NINE CORRELATED | 100 | 68 | 该途径中的所有SZGR 2.0基因 |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | 该途径中的所有SZGR 2.0基因 |
| Cervera SDHB目标2 | 114 | 76 | 该途径中的所有SZGR 2.0基因 |
| DER IFN ALPHA RESPONSE UP | 74 | 48 | 该途径中的所有SZGR 2.0基因 |
| 贝克莫昔芬的抵抗 | 50 | 36 | 该途径中的所有SZGR 2.0基因 |
| DER IFN BETA RESPONSE UP | 102 | 67 | 该途径中的所有SZGR 2.0基因 |
| BROCKE APOPTOSIS REVERSED BY IL6 | 144 | 98 | 该途径中的所有SZGR 2.0基因 |
| BYSTRYKH造血干细胞QTL Trans | 882 | 572 | 该途径中的所有SZGR 2.0基因 |
| Sasaki成人T细胞白血病 | 176 | 122 | 该途径中的所有SZGR 2.0基因 |
| Flechner活检肾脏移植OK vs捐助者 | 555 | 346 | 该途径中的所有SZGR 2.0基因 |
| DER IFN GAMMA RESPONSE UP | 71 | 45 | 该途径中的所有SZGR 2.0基因 |
| XU对维甲酸和NSC682994的响应 | 17 | 13 | 该途径中的所有SZGR 2.0基因 |
| 阿布得生活信号1 | 46 | 29 | 该途径中的所有SZGR 2.0基因 |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | 该途径中的所有SZGR 2.0基因 |
| BROWNE INTERFERON RESPONSIVE GENES | 68 | 44 | 该途径中的所有SZGR 2.0基因 |
| 盖斯对dsrna的响应 | 38 | 29 | 该途径中的所有SZGR 2.0基因 |
| BAELDE DIABETIC NEPHROPATHY DN | 434 | 302 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | 该途径中的所有SZGR 2.0基因 |
| 由Foxp3绑定的Marson未刺激 | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| Riggins他莫昔芬抵抗DN | 220 | 147 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON CANCER UP | 871 | 505 | 该途径中的所有SZGR 2.0基因 |
| 等级结肠和直肠癌 | 285 | 167 | 该途径中的所有SZGR 2.0基因 |
| VANTVEER BREAST CANCER ESR1 DN | 240 | 153 | 该途径中的所有SZGR 2.0基因 |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | 该途径中的所有SZGR 2.0基因 |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | 该途径中的所有SZGR 2.0基因 |
| 国外RB1目标成长G | 243 | 155 | 该途径中的所有SZGR 2.0基因 |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | 该途径中的所有SZGR 2.0基因 |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 该途径中的所有SZGR 2.0基因 |
| Bruins通过TP53组B响应UVC响应 | 549 | 316 | 该途径中的所有SZGR 2.0基因 |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | 该途径中的所有SZGR 2.0基因 |
| EWSR1 ETS融合的Miyagawa目标 | 259 | 159 | 该途径中的所有SZGR 2.0基因 |
| LEE BMP2 TARGETS UP | 745 | 475 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | 该途径中的所有SZGR 2.0基因 |
| YANG BCL3 TARGETS UP | 364 | 236 | 该途径中的所有SZGR 2.0基因 |
| Plasari TGFB1目标10小时DN | 244 | 157 | 该途径中的所有SZGR 2.0基因 |
| PHONG TNF RESPONSE NOT VIA P38 | 337 | 236 | 该途径中的所有SZGR 2.0基因 |