Gene Page:ATP6V0D1

Summary?
GeneID 9114
象征 ATP6V0D1
Synonyms ATP6D|ATP6DV|P39|VATX|VMA6|VPATPD
Description ATPase H+ transporting V0 subunit d1
Reference MIM:607028|HGNC:HGNC:13724|Ensembl:ENSG00000159720|HPRD:06121|Vega:OTTHUMG00000137515
Gene type protein-coding
Map location 16q22.1
Pascal p-value 2.575E-4
Sherlock p-value 0.484
Fetal beta -1.028
DMG 2 (# studies)
eGene Myers' cis & trans
Support ION BALANCE
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 4
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 4
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0972

一、遗传学和表观遗传学annotat部分ion

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg19815928 16 67514524 ATP6V0D1 -0.029 0.25 DMG:Nishioka_2013
cg15426734 16 67695272 ATP6V0D1 6.22E-5 -4.993 DMG:vanEijk_2014
cg04925864 16 67562517 ATP6V0D1 7.84E-6 -5.943 DMG:vanEijk_2014
cg18107072 16 67427811 ATP6V0D1 5.76E-5 -6.576 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs506300 chr13 78101805 ATP6V0D1 9114 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PSPC1 0.93 0.94
LRRC59 0.92 0.94
NOLC1 0.91 0.91
GRB2 0.91 0.92
ASH2L 0.91 0.91
RAD23B 0.91 0.90
C6orf168 0.91 0.90
PRPF4 0.91 0.93
VPS26B 0.91 0.91
WBP11 0.91 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.84 -0.87
FXYD1 -0.83 -0.84
AF347015.33 -0.83 -0.84
AF347015.31 -0.82 -0.84
AF347015.8 -0.81 -0.85
MT-CYB -0.81 -0.83
AF347015.27 -0.79 -0.83
AC021016.1 -0.78 -0.82
AF347015.2 -0.78 -0.83
AF347015.21 -0.78 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0016787 hydrolase activity IEA -
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism IEA -
GO:0046961 hydrogen ion transporting ATPase activity, rotational mechanism IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006811 ion transport IEA -
GO:0015992 proton transport NAS 11118322
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016469 proton-transporting two-sector ATPase complex IEA -
GO:0016471 vacuolar proton-transporting V-type ATPase complex NAS 11118322

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG OXIDATIVE PHOSPHORYLATION 135 73 All SZGR 2.0 genes in this pathway
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
KEGG霍乱弧菌感染 56 32 All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 68 44 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR RECYCLING 23 9 All SZGR 2.0 genes in this pathway
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 33 15 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 46 34 All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 80 51 All SZGR 2.0 genes in this pathway
REACTOME IRON UPTAKE AND TRANSPORT 36 18 All SZGR 2.0 genes in this pathway
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 25 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181 107 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C3 20 15 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 40 31 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
金所有说ORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
金所有说ORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 149 96 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway