基因Page:SLC16A3

Summary?
基因ID 9123
Symbol SLC16A3
Synonyms MCT 3|MCT 4|MCT-3|MCT-4|MCT3|MCT4
Description solute carrier family 16 member 3
Reference MIM:603877|HGNC:HGNC:10924|Ensembl:ENSG00000141526|HPRD:04854|Vega:OTTHUMG00000178832
基因type protein-coding
Map location 17q25
Pascal p-value 0.033
Fetal beta -1.223
DMG 1 (# studies)
eGene Myers' cis & trans

基因in Data Sources
基因set name Method of gene set Description Info
简历:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20531020 17 80188598 SLC16A3 4.005E-4 0.249 0.044 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene 基因Entrez ID pvalue qvalue TSS distance eQTL type
rs17013080 chr1 208862652 SLC16A3 9123 0.01 trans
rs4844714 chr1 208874118 SLC16A3 9123 6.517E-5 trans
rs10494904 chr1 208883320 SLC16A3 9123 0 trans
rs12097986 chr1 208883360 SLC16A3 9123 0 trans
rs10196963 chr2 60437607 SLC16A3 9123 0.19 trans
rs4256179 chr3 169628328 SLC16A3 9123 0.1 trans
rs9870311 chr3 169641061 SLC16A3 9123 0.1 trans
rs9851931 chr3 191826057 SLC16A3 9123 0.17 trans
rs871474 chr4 99562088 SLC16A3 9123 0.2 trans
rs16999761 chr4 107454800 SLC16A3 9123 4.422E-5 trans
rs7720858 chr5 43419858 SLC16A3 9123 0.18 trans
rs4516856 chr5 43889206 SLC16A3 9123 0.02 trans
rs16891983 chr5 60806764 SLC16A3 9123 0.1 trans
rs7754123 chr6 132667231 SLC16A3 9123 2.49E-4 trans
rs10252088 chr7 144943367 SLC16A3 9123 0.03 trans
rs6989594 chr8 126303866 SLC16A3 9123 0.05 trans
rs4642688 chr8 136854953 SLC16A3 9123 0.08 trans
rs17455801 chr10 80310058 SLC16A3 9123 0.13 trans
rs10743139 chr11 10425326 SLC16A3 9123 0.02 trans
rs17076272 chr13 22726361 SLC16A3 9123 3.72E-5 trans
rs17076274 chr13 22726381 SLC16A3 9123 3.72E-5 trans
rs10483856 chr14 74365294 SLC16A3 9123 0.05 trans
rs12900069 chr15 86910986 SLC16A3 9123 3.725E-4 trans
rs8072151 chr17 50228268 SLC16A3 9123 0.01 trans
rs165126 chr18 75358831 SLC16A3 9123 0.09 trans
rs4814967 chr20 20209446 SLC16A3 9123 0.16 trans
rs16981724 chr20 20210644 SLC16A3 9123 0.16 trans
rs16979494 chrX 14301660 SLC16A3 9123 0.03 trans
rs5955544 chrX 19246404 SLC16A3 9123 0.05 trans
rs6527909 chrX 19265358 SLC16A3 9123 0.1 trans
rs16982879 chrX 92924110 SLC16A3 9123 0.04 trans
rs7879274 chrX 145592957 SLC16A3 9123 1.052E-4 trans
rs5980638 chrX 148196252 SLC16A3 9123 0.07 trans
rs5980645 chrX 148205604 SLC16A3 9123 0.07 trans
rs16995035 chrX 148268500 SLC16A3 9123 0.02 trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
AGTRAP 0.72 0.82
TRAF3IP2 0.70 0.74
TST 0.70 0.79
RAMP1 0.68 0.81
NP 0.67 0.66
RAB34 0.67 0.77
TMEM149 0.67 0.61
TP53I13 0.66 0.66
IL17RB 0.66 0.60
DECR1 0.66 0.69
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
NELL2 -0.55 -0.71
DYNC1I1 -0.55 -0.66
FAM49A -0.54 -0.69
GNAI1 -0.54 -0.68
CABYR -0.53 -0.67
SPTAN1 -0.53 -0.66
STX3 -0.53 -0.68
DOCK9 -0.53 -0.60
AGTPBP1 -0.52 -0.68
LRRC7 -0.52 -0.64

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 48 32 All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 141 85 All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 30 23 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 89 54 All SZGR 2.0 genes in this pathway
REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 11 6 All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM 19 14 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS UP 44 23 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 135 82 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 2 42 31 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 29 24 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN 41 33 All SZGR 2.0 genes in this pathway
MAINA HYPOXIA VHL TARGETS UP 6 5 All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS DN 24 17 All SZGR 2.0 genes in this pathway
MAINA VHL TARGETS DN 18 14 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS UP 12 12 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
伦纳德缺氧 47 35 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS UP 43 28 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS 47 28 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
SHEDDEN肺癌生存A6差 456 285 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP 87 50 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 37 27 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 89 50 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 110 66 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162 103 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 114 69 All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 110 68 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway