Gene Page:DGKI

概括?
基因 9162
Symbol DGKI
Synonyms DGK-IOTA
Description diacylglycerol kinase iota
Reference MIM:604072|HGNC:HGNC:2855|Ensembl:ENSG00000157680|HPRD:07238|Vega:OTTHUMG00000155697
Gene type protein-coding
Map location 7q32.3-q33
Pascal p-value 3.537E-7
Fetal beta -0.477
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs3735025 chr7 137074844 TC 7.752E-9 UTR3 DGKI NM_004717:c.*1122A>G

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02085942 7 137530010 DGKI 1.605E-4 0.525 0.032 DMG:Wockner_2014
cg04425632 7 137531612 DGKI 2.201E-4 -0.291 0.036 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBM39 0.94 0.95
TIA1 0.94 0.93
PRPF38B 0.93 0.89
SF3B1 0.92 0.93
HNRPDL 0.92 0.91
PNN 0.92 0.92
LUC7L2 0.91 0.95
RSRC2 0.91 0.91
UPF3B 0.90 0.89
ZMYM5 0.90 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TNFSF12 -0.65 -0.72
AF347015.31 -0.65 -0.86
PTH1R -0.65 -0.77
IFI27 -0.64 -0.85
TSC22D4 -0.64 -0.80
HLA-F -0.64 -0.74
AIFM3 -0.64 -0.75
MT-CO2 -0.63 -0.84
AF347015.27 -0.62 -0.81
ALDOC -0.62 -0.71

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004143 diacylglycerol kinase activity TAS 9830018
GO:0005515 protein binding 新闻学会 17986458
GO:0016740 transferase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去：0007205 activation of protein kinase C activity IEA -
GO:0007242 intracellular signaling cascade IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 9830018
GO:0005737 cytoplasm TAS 9830018

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCEROLIPID METABOLISM 49 26 All SZGR 2.0 genes in this pathway
KEGG GLYCEROPHOSPHOLIPID METABOLISM 77 35 All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME EFFECTS OF PIP2 HYDROLYSIS 25 17 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 100 75 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221 120 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 389 395 1A HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
miR-103/107 831 837 1A HSA-MIR-103brain AGCAGCAUUGUACAGGGCUAUGA
HSA-MIR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-144 389 395 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-22 62 68 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-493-5p 161 168 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU