Gene Page:CD3G
Summary?
| GeneID | 917 |
| Symbol | CD3G |
| Synonyms | CD3-GAMMA|IMD17|T3G |
| Description | CD3g molecule |
| Reference | MIM:186740|HGNC:HGNC:1675|HPRD:07037| |
| Gene type | protein-coding |
| Map location | 11q23 |
| Pascal p-value | 0.012 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004888 | transmembrane receptor activity | IMP | 12794121 | |
| GO:0030159 | receptor signaling complex scaffold activity | NAS | 12794121 | |
| GO:0042608 | T cell receptor binding | NAS | 11186279 | |
| GO:0046982 | protein heterodimerization activity | 新闻学会 | 9485181 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006461 | protein complex assembly | NAS | 12794121 | |
| GO:0007166 | cell surface receptor linked signal transduction | IMP | 12407027 | |
| GO:0007163 | establishment or maintenance of cell polarity | IMP | 12407027 | |
| GO:0042981 | regulation of apoptosis | IMP | 12407027 | |
| GO:0015031 | protein transport | IMP | 12794121 | |
| GO:0042110 | T cell activation | NAS | 12407027 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0042101 | T cell receptor complex | NAS | Synap (GO term level: 8) | 9485181 |
| GO:0005886 | plasma membrane | EXP | 11048639|11827988|15489916 |17652306 |
|
| GO:0005887 | integral to plasma membrane | NAS | 9485181 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HEMATOPOIETIC CELL LINEAGE | 88 | 60 | All SZGR 2.0 genes in this pathway |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CSK PATHWAY | 24 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CTL PATHWAY | 15 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCAPOPTOSIS PATHWAY | 11 | 8 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL17 PATHWAY | 17 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL12 PATHWAY | 23 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCRA PATHWAY | 13 | 10 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NO2IL12 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TOB1 PATHWAY | 21 | 14 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STATHMIN PATHWAY | 19 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCR PATHWAY | 49 | 37 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCYTOTOXIC PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA THELPER PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CTLA4 PATHWAY | 21 | 18 | All SZGR 2.0 genes in this pathway |
| PID TCR PATHWAY | 66 | 51 | All SZGR 2.0 genes in this pathway |
| PID IL12 2PATHWAY | 63 | 54 | All SZGR 2.0 genes in this pathway |
| PID CD8 TCR PATHWAY | 53 | 42 | All SZGR 2.0 genes in this pathway |
| PID CXCR4 PATHWAY | 102 | 78 | All SZGR 2.0 genes in this pathway |
| PID CD8 TCR DOWNSTREAM PATHWAY | 65 | 56 | All SZGR 2.0 genes in this pathway |
| PID IL12 STAT4 PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 70 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME TCR SIGNALING | 54 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM TCR SIGNALING | 37 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | 16 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | 14 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME GENERATION OF SECOND MESSENGER MOLECULES | 27 | 25 | All SZGR 2.0 genes in this pathway |
| REACTOME PD1 SIGNALING | 18 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 63 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME适应IVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| AKL HTLV1 INFECTION DN | 68 | 41 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1B TARGETS | 92 | 68 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| 乳腺癌萧述三腔的DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| BHATI G2M ARREST BY 2METHOXYESTRADIOL DN | 127 | 75 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
| VILIMAS NOTCH1 TARGETS UP | 52 | 41 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS DN | 366 | 257 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |
| CAIRO LIVER DEVELOPMENT DN | 222 | 141 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 2 DN | 9 | 8 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 DN | 38 | 19 | All SZGR 2.0 genes in this pathway |