Gene Page:KCNAB3

Summary?
GeneID 9196
Symbol KCNAB3
Synonyms AKR6A9|KCNA3.1B|KCNA3B|KV-BETA-3
Description potassium voltage-gated channel subfamily A regulatory beta subunit 3
Reference MIM:604111|HGNC:HGNC:6230|Ensembl:ENSG00000170049|HPRD:04983|Vega:OTTHUMG00000108170
Gene type protein-coding
Map location 17p13.1
Pascal p-value 0.012
DEG p-value DEG:Zhao_2015:p=7.02e-04:q=0.0984
Fetal beta -0.044
DMG 1 (# studies)
eGene Cerebellar Hemisphere
小脑
Cortex

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DEG:Zhao_2015 RNA Sequencing analysis Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07367232 17 7826266 KCNAB3 9.32E-10 -0.012 1.11E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SKIV2L2 0.94 0.91
UBA2 0.92 0.89
IPO5 0.92 0.92
ZNF143 0.91 0.90
DHX15 0.91 0.91
GMPS 0.91 0.91
CUL4B 0.91 0.92
DNAJC18 0.91 0.91
PPP1CC 0.91 0.86
PPAT 0.91 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.71 -0.81
AF347015.31 -0.70 -0.81
AF347015.8 -0.69 -0.81
MT-CYB -0.68 -0.79
AF347015.33 -0.68 -0.77
AF347015.21 -0.67 -0.80
AF347015.27 -0.67 -0.78
IFI27 -0.67 -0.78
HIGD1B -0.66 -0.78
FXYD1 -0.66 -0.78

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 43 32 All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS 98 68 All SZGR 2.0 genes in this pathway
STAEGE EWING FAMILY TUMOR 33 22 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 170 97 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP 112 64 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 118 68 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway