Gene Page:ACVR2A

Summary？
基因 92
象征 ACVR2A
Synonyms ACTRII|ACVR2
Description activin A receptor type 2A
Reference MIM:102581|HGNC：HGNC：173|ENSEMBL：ENSG00000121989|HPRD：00025|Vega：Otthumg00000150603
基因类型 蛋白质编码
Map location 2q22.3
Pascal p-value 0.046
胎儿β 1.173
DMG 1(# studies)
主持人 Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：Nishioka_2013 全基因组DNA甲基化分析 作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。 1
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.02395

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG22464182 2 148602625 ACVR2A -0.024 0.25 DMG：Nishioka_2013

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS5973375 Chrx 35489060 ACVR2A 92 0.14 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ABHD14A 0.96 0.95
TEX264 0.87 0.83
ISOC2 0.86 0.88
CYC1 0.84 0.81
Fastk 0.84 0.83
3月2日 0.84 0.81
MFSD3 0.83 0.86
C11orf59 0.83 0.86
SLC25A11 0.83 0.78
GPX4 0.83 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF5B -0.60 -0.70
RBM25 -0.53 -0.55
SFRS12 -0.53 -0.53
ZNF326 -0.52 -0.50
AC005921.3 -0.49 -0.69
thoc2 -0.48 -0.47
PPIG -0.47 -0.45
PRPF38B -0.47 -0.47
SFRS18 -0.46 -0.58
ESF1 -0.45 -0.41

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0000166 nucleotide binding IEA -
去：0000287 magnesium ion binding IEA -
去：0005524 ATP binding IEA -
GO：0016740 转移酶活性 IEA -
GO：0019838 growth factor binding IEA -
GO：0017002 激活素受体活性 IDA 12665502
GO：0015026 coreceptor activity IDA 10746731
GO:0030145 锰离子结合 IEA -
GO：0048185 activin binding IPI 9032295
GO：0048186 抑制蛋白β-A​​结合 IDA 7890768
GO：0043621 protein self-association IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0001702 gastrulation with mouth forming second IEA -
去：0006468 protein amino acid phosphorylation IEA -
GO:0007368 确定左/右对称性 IEA -
GO:0007283 spermatogenesis IEA -
去：0009952 anterior/posterior pattern formation IEA -
GO:0007498 中胚层开发 IEA -
去：0050999 regulation of nitric-oxide synthase activity IEA -
GO：0042713 精子射精 IEA -
去：0030501 骨矿化的阳性调节 IMP 18436533
去：0030509 BMP信号通路 经验 15621726
去：0030509 BMP信号通路 IDA 18436533
GO:0043084 penile erection IEA -
GO：0032927 激活素受体信号通路的正调控 IDA 12665502
GO:0045648 positive regulation of erythrocyte differentiation IDA 9032295
GO:0045669 成骨细胞分化的阳性调节 IMP 18436533
GO:0048706 胚胎骨骼系统开发 IEA -
去：0060011 Sertoli细胞增殖 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005737 cytoplasm IDA 14738881
去：0005886 plasma membrane 经验 17356069
去：0005887 integral to plasma membrane TAS 1314589

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ACVR1B Actrib |ACVRLK4 |ALK4 |SKR2 激活素A受体，类型Ib - HPRD,BioGRID 8612709
BMP6 VGR | VGR1 bone morphogenetic protein 6 - HPRD,BioGRID 10504300
BMP7 OP-1 bone morphogenetic protein 7 - HPRD,BioGRID 9748228
工程 CD105 | END | FLJ41744 | HHT1 | ORW | ORW1 endoglin - HPRD,BioGRID 9872992
GDF5 BMP14 |CDMP1 |lap4 |SYNS2 生长分化因子5 - HPRD,BioGRID 8702914
GDF9 - 生长分化因子9 - HPRD 12135884
IGSF1 IGCD1 | IGDC1 | INHBP | KIAA0364 | MGC75490 | PGSF2 免疫球蛋白超家族，成员1 - HPRD 11266516
inha - inhibin, alpha 亲和力捕获 - 韦斯特恩 Biogrid 10746731
INHBA EDF | FRP 抑制素，βa 亲和力捕获 - 韦斯特恩 Biogrid 9202237|10746731
INHBA EDF | FRP 抑制素，βa - HPRD 11266516
INHBB MGC157939 抑制素，βb 亲和力捕获 - 韦斯特恩 Biogrid 9202237
INHBB MGC157939 抑制素，βb - HPRD 11266516
INHBC IHBC 抑制素，βC - HPRD 12651901
magi2 ACVRIP1 | AIP1 | ARIP1 | MAGI-2 | SSCAM 膜相关的鸟苷酸激酶，WW和PDZ结构域，含有2个 - HPRD 10681527
synj2bp ARIP2 | FLJ11271 | FLJ41973 | OMP25 synaptojanin 2 binding protein - HPRD,BioGRID 11882656|15451561
TGFBR3 BGCAN | betaglycan 反式forming growth factor, beta receptor III - HPRD 10746731


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
PID ALK1途径 26 21 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
淋巴结的反应组信号传导 18 11 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 23 15 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD DN 84 63 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 67 33 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
Zhu CMV 8小时DN 53 40 All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP 84 55 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
伯顿成生成11 57 40 All SZGR 2.0 genes in this pathway
伯顿成生成9 92 59 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性 578 341 All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY 29 25 All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI 28 23 All SZGR 2.0 genes in this pathway
mir15a和mir16 1的Bonci目标 91 75 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟A 67 52 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
甜肺癌Kras DN 435 289 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP 66 44 All SZGR 2.0 genes in this pathway
中村脂肪形成晚期 104 67 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
let-7/98 589 595 1A hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
mir-1/206 3512 3518 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
mir-124.1 1420 1426 M8 HSA-MIR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1420 1426 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 1279 1285 1A hsa-miR-125bbrain ucccugagacccuaacuuguga
hsa-miR-125abrain ucccugagacccuuaaccugug
miR-128 676 682 M8 hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
mir-130/301 2853 2860 1A，M8 hsa-miR-130abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-138 3266 3272 1A HSA-MIR-138brain AGCUGGUGUUGUGAAUC
miR-141/200a 2689 2695 M8 HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-142-3p 1725 1732 1A，M8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-145 970 976 1A HSA-MIR-145 guccaguuucccaggaaucccuu
HSA-MIR-145 guccaguuucccaggaaucccuu
miR-15/16/195/424/497 47 53 1A HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
miR-150 153 159 1A HSA-MIR-150 UCUCCCAACCCUUGUACCAGUG
miR-153 1312 1318 1A HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
miR-155 559 565 M8 HSA-MIR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-181 489 495 M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 1170 1176 M8 HSA-MIR-183 UAUGGCACUGGUAGAAUUCACUG
miR-185 265 271 1A HSA-MIR-185brain UGGAGAGAAAGGCAGUUC
miR-188 1281 1287 1A HSA-MIR-188 cucccuugcaugguggggu
mir-192/215 1797 1804 1A，M8 HSA-MIR-192 cugaccuaugaauugacagcc
hsa-miR-215 Augaccuaugaauugacagac
miR-193 1591年 1597年 1A HSA-MIR-193A AACUGGCCUACAAAGUCCCAG
HSA-MIR-193B aacuggcccucaaagucccgcuuu
miR-196 2341 2347 M8 HSA-MIR-196A uagguaguucauguugugug
HSA-MIR-196B UAGGUAGUUUCCUGUUGUUGG
miR-199 968 975 1A，M8 HSA-MIR-199A CCCAGUGUUCAGACUACCUGUUC
HSA-MIR-199B cccaguguuuagacuaucuuc
miR-200bc/429 1593年 1600 1A，M8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 398 404 1A hsa-miR-203 ugaaauguuuaggaccacuag
miR-21 52 58 1A hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa - mir - 590 gagcuuauucauaaaaagugcag
hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa - mir - 590 gagcuuauucauaaaaagugcag
mir-217 3284 3290 M8 hsa-miR-217 uacugcaucagaacugauuggau
mir-223 312 319 1A，M8 hsa-miR-223 ugucuuugucaauacccc
miR-27 1682 1689 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 2544 2550 M8 HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ UAGCACCAUUUGAAAUCGGU
mir-30-5p 2401 2407 1A HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-362 275 281 M8 HSA-MIR-362 aauccuuggaaccuaggugugugugugugagu
mir-369-3p 1595年 1601 M8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 612 618 1A HSA-MIR-374 uuauaauacaAccugauaagug
miR-378 1095 1101 1A HSA-MIR-378 CUCCUGACUCCAGGUCCUGUGU
mir-380-5p 3263 3269 1A hsa-miR-380-5p UGGUUGACCAUAGAACAUGCGC
hsa-miR-563 AGGUUGACAUACGUUUCCC
miR-381 2729 2735 M8 HSA-MIR-381 uauacaagggcaagcucucugu
mir-409-5p 1330 1337 1A，M8 HSA-MIR-409-5P AGGUUACCCGAGCAACUUUGCA
mir-448 1311 1318 1A，M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p 3486 3492 1A HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-495 3307 3313 1A HSA-MIR-495brain Aaacaaacauggugcacuuuuu
mir-503 47 53 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
mir-543 2328 2334 M8 hsa-miR-543 aaacauucgcggugcacuucu
mir-96 715 721 M8 hsa-miR-96brain uuuggcacuagcacauuuuugc