Gene Page:CD4

概括？
GeneID 920
象征 CD4
Synonyms CD4MUT
Description CD4分子
Reference MIM:186940|HGNC：HGNC：1678|Ensembl:ENSG00000010610|HPRD:01740|Vega：Otthumg00000168514
基因类型 蛋白质编码
Map location 12p13.31
Pascal p-value 0.02
Sherlock p-value 0.001
胎儿β -0.418

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association A combined odds ratio method (Sun等。2008), association studies 1 Link to SZGene
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RNF44 0.68 0.71
SCMH1 0.67 0.70
STK11IP 0.66 0.68
NPHP4 0.65 0.67
mppe1 0.65 0.69
陶克2 0.65 0.66
ULK1 0.65 0.68
CCRK 0.65 0.67
Zmiz2 0.65 0.70
TAF6 0.64 0.68
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.53 -0.55
AF347015.21 -0.52 -0.56
MT-CO2 -0.51 -0.53
AL139819.3 -0.50 -0.55
AF347015.2 -0.49 -0.50
mt-cyb -0.48 -0.51
AF347015.8 -0.48 -0.51
GNG11 -0.47 -0.55
HIGD1B -0.47 -0.51
AF347015.26 -0.46 -0.47

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0004888 跨膜受体活性 TAS 10358157
GO:0001948 糖蛋白结合 IPI 10922058
去：0005201 细胞外基质结构成分 nas 12444132
GO:0008270 zinc ion binding IDA 9668045
GO:0042289 MHC class II protein binding nas 8512039
GO：0015026 coreceptor activity nas 8512039
GO：0042803 蛋白质同构化活性 IDA 12444132
GO：0019901 protein kinase binding IPI 7486703
Biological process 去学期 证据 神经关键字 PubMed ID
GO:0000747 与细胞融合结合 IDA 9166430
GO:0001816 cytokine production IEA -
GO:0007169 跨膜受体蛋白酪氨酸激酶信号传导途径 nas 8512039
GO:0007155 cell adhesion IEA -
去：0006955 免疫反应 nas 8512039
GO:0019059 initiation of viral infection EXP 12091904
GO：0050870 T细胞激活的阳性调节 IEA -
GO:0045860 蛋白激酶活性的阳性调节 IDA 2118992
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA -
GO:0050850 钙介导的信号传导的阳性调节 IEA -
GO：0045086 白介素-2生物合成过程的积极调节 nas 1901411
GO：0045058 T细胞选择 IDA 9551897
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0042101 T cell receptor complex nas 突触（GO期限：8） 8512039
去：0005789 内质网膜 EXP 9660940
去：0005769 early endosome EXP 2014052|15202998
GO:0016021 膜不可或缺 IEA -
GO:0009897 external side of plasma membrane IEA -
去：0005886 plasma membrane EXP 2014052|11048639|11827988
|15202998|15489916
|17652306
去：0005886 plasma membrane IDA 8124721

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
BTRC beta-trcp |fbw1a |fbxw1 |fbxw1a |FWD1 |MGC4643 |BTRCP |BTRCP1 |betatrcp beta-transducin重复含有 - HPRD,BioGRID 9660940
CCR5 CC-CKR-5 |CCCKR5 |CD195 |CKR-5 |CKR5 |CMKBR5 趋化因子（C-C基序）受体5 - HPRD,BioGRID 10816381
CD2 SRBC |T11 CD2 molecule - HPRD 7539755
CD28 MGC138290 |TP44 CD28分子 - HPRD 7539755
CD38 T10 CD38分子 - HPRD 7539755
CD4 CD4MUT CD4分子 CD4 forms homodimers. 绑定 12444132
CD44 CDW44 |CSPG8 |ECMR-III |hcell |在|lhr |MC56 |mdu2 |mdu3 |MGC10468 | MIC4 | MUTCH-I | Pgp1 CD44分子（印度血型） - HPRD 7539755
CD5 LEU1 | T1 CD5分子 - HPRD 7539755
CD53 MOX44 | TSPAN25 CD53分子 - HPRD 7539755
CD81 S5.7 | TAPA1 | TSPAN28 CD81分子 亲和力捕获 - 韦斯特恩 Biogrid 7636191
CD82 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 CD82分子 - HPRD,BioGRID 7636191
CTSD Cln10 |CPSD |MGC2311 cathepsin D - HPRD 11581410
CXCL12 PBSF | SCYB12 | SDF-1a | SDF-1b | SDF1 | SDF1A | SDF1B | TLSF-a | TLSF-b | TPAR1 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) - HPRD 10600606
CXCR4 CD184 |D2S201E |FB22 |HM89 |hsy3rr |lap3 |lcr1 |LESTR |npy3r |npyr | NPYRL | NPYY3R | WHIM chemokine (C-X-C motif) receptor 4 亲和力捕获 - 韦斯特恩 Biogrid 10816381
FCGR3A CD16 |CD16A |FCG3 |FCGR3 |fcgriii |FCR-10 |fcriii |fcriiia |IGFR3 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) - HPRD 11756173
HLA-DPA1 HLA-DP1A |HLADP |HLASB major histocompatibility complex, class II, DP alpha 1 - HPRD 12899833
HLA-DQA2 HLA-DXA 主要的组织相容性复合物，II类，DQ alpha 2 - HPRD 11535811
IL16 FLJ16806 |FLJ42735 |FLJ44234 |HST19289 |IL-16 |LCF |Pril-16 白介素16（淋巴细胞趋化因子） - HPRD,BioGRID 1851800 | 7910967
IL2RA CD25 |IDDM10 |IL2R |TCGFR interleukin 2 receptor, alpha - HPRD 7539755
KCNAB2 AKR6A5 | HKvbeta2 | HKvbeta2.1 | HKvbeta2.2 | KCNA2B | KV-BETA-2 | MGC117289 potassium voltage-gated channel, shaker-related subfamily, beta member 2 亲和力捕获 - 韦斯特恩 Biogrid 12893943
拉特 拉特1|pp36 激活T细胞的接头 - HPRD 10562325
LCK YT16 | p56lck | pp58lck lymphocyte-specific protein tyrosine kinase - HPRD,BioGRID 11854499
LGALS1 DKFZp686E23103 | GAL1 | GBP 凝集素，半乳糖苷结合，可溶性，1 体外 Biogrid 10490978
3月4日 MARCH-IV | MGC104908 | RNF174 membrane-associated ring finger (C3HC4) 4 - HPRD 14722266
PI4KA FLJ16556 |pi4k-alpha |pik4ca |PI4K230 磷脂酰肌醇4-激酶，催化，α - HPRD 8246987
PIK3R1 GRB1 | p85 | p85-ALPHA 磷酸肌醇3-激酶，调节亚基1（alpha） - HPRD 8246987
pip GCDFP-15 | GCDFP15 | GPIP4 催乳素诱导的蛋白质 - HPRD,BioGRID 10820003
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2 protein tyrosine kinase 2 - HPRD 10384144
ptprc B220 |CD45 |CD45R |GP180 |LCA |ly5 |T200 蛋白酪氨酸磷酸酶，受体类型，C - HPRD,BioGRID 1834739
SELL CD62L | LAM-1 | LAM1 | LECAM1 | LNHR | LSEL | LYAM1 | Leu-8 | Lyam-1 | PLNHR | TQ1 | hLHRc selectin L - HPRD 7539755
SPG21 ACP33 | BM-019 | GL010 | MASPARDIN | MAST 痉挛性截瘫21（常染色体隐性，桅杆综合征） - HPRD,BioGRID 11113139
TNFRSF10A apo2 |CD261 |DR4 |MGC9365 |TRAILR-1 |TRAILR1 tumor necrosis factor receptor superfamily, member 10a - HPRD 7650480
UNC119 HRG4 unc-119 homolog (C. elegans) - HPRD,BioGRID 14757743


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg细胞粘附分子凸轮 134 93 All SZGR 2.0 genes in this pathway
KEGG抗原处理和演示 89 65 All SZGR 2.0 genes in this pathway
KEGG造血细胞谱系 88 60 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG初级免疫缺陷 35 28 All SZGR 2.0 genes in this pathway
Biocarta CSK途径 24 20 All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY 12 11 All SZGR 2.0 genes in this pathway
Biocarta fordam途径 29 24 All SZGR 2.0 genes in this pathway
生物核心凋亡途径 11 8 All SZGR 2.0 genes in this pathway
Biocarta IL17途径 17 12 All SZGR 2.0 genes in this pathway
Biocarta IL5途径 10 9 All SZGR 2.0 genes in this pathway
Biocarta TCRA途径 13 10 All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 17 14 All SZGR 2.0 genes in this pathway
生物卡塔茎途径 15 13 All SZGR 2.0 genes in this pathway
Biocarta NKT途径 29 21 All SZGR 2.0 genes in this pathway
Biocarta thper Pathway 14 11 All SZGR 2.0 genes in this pathway
PID TCR途径 66 51 All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 63 54 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID CMYB途径 84 61 All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 37 30 All SZGR 2.0 genes in this pathway
PID ARF 3 Pathway 19 13 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
PID IL12 STAT4途径 33 29 All SZGR 2.0 genes in this pathway
REACTOME NEF介导细胞冲浪的调制ACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 12 All SZGR 2.0 genes in this pathway
反应组防御素 51 12 All SZGR 2.0 genes in this pathway
Reactome TCR信号传导 54 46 All SZGR 2.0 genes in this pathway
Reactome下游TCR信号传导 37 32 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 16 15 All SZGR 2.0 genes in this pathway
ZAP 70向免疫突触的Reactome易位 14 14 All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 27 25 All SZGR 2.0 genes in this pathway
Reactome PD1信号传导 18 14 All SZGR 2.0 genes in this pathway
CD28家族的Reactome共刺激 63 48 All SZGR 2.0 genes in this pathway
Reactome HIV感染 207 122 All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 125 69 All SZGR 2.0 genes in this pathway
REACTOME EARLY PHASE OF HIV LIFE CYCLE 21 8 All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
Reactome先天免疫系统 279 178 All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 28 19 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN 463 290 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
SHANK TAL1 TARGETS DN 10 6 All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA 70 38 All SZGR 2.0 genes in this pathway
肯尼CTNNB1靶向DN 52 34 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS UP 29 23 All SZGR 2.0 genes in this pathway
Nielsen Gist和滑膜肉瘤DN 20 15 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 86 66 All SZGR 2.0 genes in this pathway
布朗HCMV感染48小时 180 125 All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN 245 144 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 49 29 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
WILENSKY RESPONSE TO DARAPLADIB 29 20 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 36 23 All SZGR 2.0 genes in this pathway
fontaine乳头状甲状腺癌 66 38 All SZGR 2.0 genes in this pathway
MOOTHA GLUCONEOGENESIS 32 23 All SZGR 2.0 genes in this pathway
Mootha糖酵解 21 13 All SZGR 2.0 genes in this pathway
Nielsen滑膜肉瘤DN 20 13 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-181 74 81 1A，M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
mir-221/222 77 84 1A，M8 HSA-MIR-221brain agcuacauugucugugggggguc
HSA-MIR-222brain agcuacaucuggcuacugggucuc