Gene Page:XPR1

Summary?
GeneID 9213
Symbol XPR1
Synonyms IBGC6|SYG1|X3
Description xenotropic and polytropic retrovirus receptor 1
Reference MIM:605237|HGNC:HGNC:12827|Ensembl:ENSG00000143324|HPRD:05574|Vega:OTTHUMG00000035116
Gene type protein-coding
Map location 1q25.1
Sherlock p-value 0.646
TADA p-value 0.002
Fetal beta 2.26
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis 新创4基因的突变被交货确认ome sequencing of 795 samples in this study
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
XPR1 chr1 180843041 A ATTGCTTTGTTGCC NM_001135669
NM_001135669
NM_004736
NM_004736		 p.526*>*
.
p.591*>*
.		 indel
frameshift
indel
frameshift		 Schizophrenia DNM:Xu_2012

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10497672 0 XPR1 9213 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SCN2A 0.81 0.86
RIMBP2 0.80 0.85
STXBP5 0.79 0.85
SCN3B 0.78 0.83
MYCBP2 0.78 0.83
CSMD1 0.78 0.85
DGKE 0.77 0.81
FGF14 0.77 0.82
DOCK3 0.77 0.83
BTBD9 0.77 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.47 -0.53
AF347015.21 -0.47 -0.52
TLCD1 -0.47 -0.50
EIF4EBP3 -0.47 -0.52
MT-CO2 -0.47 -0.55
FXYD1 -0.46 -0.49
HIGD1B -0.46 -0.54
ACSF2 -0.46 -0.52
PLA2G5 -0.46 -0.50
ENHO -0.46 -0.55

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 47 34 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 116 87 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway