基因页：mtdh

Summary？
基因 92140
象征 mtdh
同义词 3D3 | AEG-1 | AEG1 | Lyric | Lyric/3d3
Description metadherin
Reference MIM：610323|HGNC：HGNC：29608|ENSEMBL：ENSG00000147649|HPRD：17459|Vega:OTTHUMG00000164692
基因类型 蛋白质编码
地图位置 8q22.1
Pascal P值 0.153
Sherlock p-value 0.01
胎儿β 0.414
DMG 1(# studies)
支持 G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS

Gene in Data Sources
基因集名称 基因组方法 Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
简历：PGCNP 全基因组协会研究 GWAS
DMG：Vaneijk_2014 全基因组DNA甲基化分析 该数据集包括432个差异甲基化的CpG位点，对应于精神分裂症患者（n = 260）和未受影响的对照（n = 250）之间的391个独特的转录本。 1
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@差异甲基化基因

探测 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG05237543 8 98656054 mtdh 0.011 -3.622 DMG：Vaneijk_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 18316612
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005923 紧密连接 IEA 大脑（GO期限：10） -
去：0005789 内质网膜 IEA -
去：0005634 nucleus IEA -
去：0005730 核仁 艾达 18029348
去：0005783 内质网 IEA -
去：0016020 membrane IEA -
GO：0016021 膜不可或缺 IEA -
GO：0030054 cell junction IEA -
GO：0031965 核膜 IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID MYC活动途径 79 62 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病 368 234 All SZGR 2.0 genes in this pathway
Basaki YBX1靶向DN 384 230 All SZGR 2.0 genes in this pathway
Wang LMO4靶向 372 227 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向 135 82 All SZGR 2.0 genes in this pathway
Tien肠益生菌24小时DN 214 133 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时 162 116 All SZGR 2.0 genes in this pathway
Bidus转移 214 134 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
由EWS FLT1融合绑定的Siligan 47 34 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标 795 478 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
Stark前额叶皮层22Q11删除 195 138 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
Nikolsky乳腺癌8Q12 Q22 AMPLICON 132 82 All SZGR 2.0 genes in this pathway
Shepard BMYB Morpholino Up 205 126 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 121 65 All SZGR 2.0 genes in this pathway
彭雷帕霉素反应dn 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK 63 48 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
MLL AF9融合的Kumar目标 405 264 All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞长期 302 191 All SZGR 2.0 genes in this pathway
MariaDason对丁酸姜黄素Sulindac TSA 8的反应 16 7 All SZGR 2.0 genes in this pathway
24HR 55 38 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
monnier tradiatiation肿瘤逃脱 393 244 All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞 156 92 All SZGR 2.0 genes in this pathway
张乳腺癌祖细胞 425 253 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER POOR PROGNOSIS 55 30 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤MF DN 41 28 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
双龙血清敏感基因 90 54 All SZGR 2.0 genes in this pathway
wakabayashi脂肪生成PPARG RXRA绑定8D 882 506 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-124.1 978 985 1A，M8 HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
mir-124/506 978 984 1a HSA-MIR-506 uaaggcacccuucugugaguaga
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-128 1143 1149 M8 hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
miR-135 1294 1300 M8 HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
miR-153 61 67 1a HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
mir-25/32/92/363/367 63 69 1a hsa-miR-25brain Cauugcacuugucucggucuga
HSA-MIR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
mir-26 652 659 1A，M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-299-5p 103 109 1a hsa-miR-299-5p ugguuuaccgucccacauacau
mir-30-5p 287 294 1A，M8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-320 924 931 1A，M8 HSA-MIR-320 aaaagcugggugagaggggcgaa
HSA-MIR-320 aaaagcugggugagaggggcgaa
mir-330 438 445 1A，M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-34b 976 982 M8 hsa-miR-34b uaggcagugucauagcugauug
miR-363 512 518 1a HSA-MIR-363 auugcacgguauccaucuguaa
miR-378 958 964 1a HSA-MIR-378 CUCCUGACUCCAGGUCCUGUGU
mir-410 92 98 1a HSA-MIR-410 aauauaacacagauggcugu
mir-448 1001 1007 M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p 80 86 M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-494 1548 1554 1a HSA-MIR-494brain ugaaacauacgggaaaccucuu
miR-496 1048 1054 M8 HSA-MIR-496 Auuacauggccaaucuc