Gene Page:CD6

Summary?
GeneID 923
Symbol CD6
Synonyms TP120
Description CD6 molecule
Reference MIM:186720|HGNC:HGNC:1691|Ensembl:ENSG00000013725|HPRD:01724|Vega:OTTHUMG00000167823
Gene type protein-coding
Map location 11q13
Pascal p-value 0.656
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24674703 11 60869960 CD6 3.47E-6 -5.635 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11230563 11 60776209 CD6 ENSG00000013725.10 3.69797E-9 0 37094 gtex_brain_ba24
rs2074227 11 60776781 CD6 ENSG00000013725.10 3.74396E-9 0 37666 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CA2 0.90 0.93
CBR1 0.90 0.90
MAL 0.89 0.91
APOD 0.88 0.93
PLLP 0.88 0.92
CYP27A1 0.87 0.91
CMTM5 0.86 0.92
DBNDD2 0.86 0.88
EVI2A 0.86 0.90
CRYAB 0.85 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1949 -0.70 -0.72
NKIRAS2 -0.70 -0.71
TUBB2B -0.69 -0.74
ZNF821 -0.69 -0.71
MPP3 -0.69 -0.70
CRMP1 -0.68 -0.71
ZNF551 -0.68 -0.72
GMIP -0.68 -0.71
AC004017.1 -0.68 -0.72
PCDHB18 -0.67 -0.72

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384 220 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 104 59 All SZGR 2.0 genes in this pathway
SHANK TAL1 TARGETS DN 10 6 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 158 93 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
FERRANDO TAL1 NEIGHBORS 21 15 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 142 93 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 52 33 All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP 28 23 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS CANCER UP 31 23 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN 116 83 All SZGR 2.0 genes in this pathway
WANG TNF TARGETS 24 17 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway