Gene Page:MSC

Summary?
GeneID 9242
Symbol MSC
Synonyms ABF-1|ABF1|MYOR|bHLHa22
Description musculin
Reference MIM:603628|HGNC:HGNC:7321|Ensembl:ENSG00000178860|HPRD: 04694|Vega:OTTHUMG00000164489
Gene type protein-coding
Map location 8q21
Pascal p-value 0.506
Sherlock p-value 0.404
Fetal beta -1.356
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypal Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6472656 chr8 72928114 MSC 9242 0.1 cis
rs17449278 chr1 57437250 MSC 9242 0.19 trans
rs17416642 chr1 57471620 MSC 9242 0.1 trans
rs16827037 chr3 117203284 MSC 9242 0.07 trans
rs11066476 chr12 113465366 MSC 9242 0.19 trans
rs2444983 chr15 33443919 MSC 9242 0.09 trans
rs9302779 chr16 3933344 MSC 9242 0.13 trans
rs9902506 chr17 10051361 MSC 9242 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MRPS7 0.90 0.84
NDUFAB1 0.89 0.91
UQCRFSL1 0.89 0.88
C20orf24 0.89 0.87
ATP5G1 0.88 0.80
ATP5G3 0.88 0.84
ERI3 0.88 0.79
SDHB 0.88 0.84
HAX1 0.88 0.82
FAM58A 0.88 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC010300.1 -0.47 -0.66
MTSS1L -0.45 -0.44
AF347015.18 -0.45 -0.39
C10orf108 -0.45 -0.51
AC010618.2 -0.45 -0.50
MYH9 -0.44 -0.37
GP1BA -0.44 -0.49
AP000769.2 -0.44 -0.56
AC016705.1 -0.44 -0.44
Z83840.4 -0.44 -0.45

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 84 54 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE DN 29 19 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179 105 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 132 82 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR DN 47 31 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 84 60 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 68 50 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 112 65 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN 187 109 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway