SZGR2 - Beplay体育中心

Summary？

GeneID	928
象征	CD9
Synonyms	BTCC-1 \| DARAP-27 \| MIC3 \| MRP-1 \| TSPAN-29 \| TSPAN29
Description	CD9分子
参考erence	MIM：143030\|HGNC：HGNC：1709\|Ensembl：ENSG00000010278\|HPRD:00880\|Vega：Otthumg00000044400
基因类型	蛋白质编码
Map location	12p13.3
Pascal p-value	0.469
Sherlock p-value	0.381
胎儿β	-2.102
DMG	1 (# studies)

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	2
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

DNM表

Gene	染色体	位置	参考	alt	成绩单	AA change	Mutation type	Sift	CG46	特征	学习
CD9	chr12	6334597	C	t	NM_001769	。	silent			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
cg19615684	12	6310744	CD9	2.057E-4	-0.504	0.035	DMG：Wockner_2014
cg02586910	12	6314603	CD9	5。207E-4	-0.712	0.048	DMG：Wockner_2014

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
tMEM63A	0.92	0.92
PCTK3	0.90	0.94
AC087645.1	0.90	0.95
ATPGD1	0.90	0.93
PLXNB3	0.90	0.91
CERCAM	0.89	0.55
sema3b	0.88	0.86
ERBB3	0.88	0.90
P2RX7	0.88	0.84
LDB3	0.88	0.91

top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
Med19	-0.50	-0.75
STMN1	-0.49	-0.76
RPL12	-0.49	-0.78
POLB	-0.49	-0.77
NKIRAS2	-0.49	-0.71
ALKBH2	-0.49	-0.79
IFT52	-0.48	-0.77
NR2C2AP	-0.48	-0.78
HN1	-0.48	-0.76
RARS2	-0.48	-0.75

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005515	蛋白质结合	IEA		-
去：0005515	蛋白质结合	IPI		11278880\|11504738
Biological process	去学期	证据	神经关键字	PubMed ID
去：0030913	偏an道路交界集议会	IEA	Axon，Glial（GO期限：15）	-
去：0030913	偏an道路交界集议会	ISS	Axon，Glial（GO期限：15）	-
GO:0007155	cell adhesion	IDA		7511626
GO:0008285	negative regulation of cell proliferation	IEA		-
GO:0030168	血小板激活	nas		2037603
GO:0006928	cell motion	IDA		8478605
去：0007342	精子融合到卵质膜	IDA		14575715
去：0007342	精子融合到卵质膜	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016021	膜不可或缺	IEA		-
去：0005886	plasma membrane	EXP		10515286
去：0005886	plasma membrane	nas		6198179
去：0005887	integral to plasma membrane	nas		2037603
GO:0031092	血小板α颗粒膜	EXP		10515286

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ADAM2	CRYN1 \| CRYN2 \| FTNB \| PH-30b \| PH30	ADAM metallopeptidase domain 2	-	HPRD	10518536
CD19	B4 \|MGC12802	CD19 molecule	-	HPRD,BioGRID	9804823
CD36	CHDS7 \| FAT \| GP3B \| GP4 \| GPIV \| PASIV \| SCARB3	CD36分子（血小板传播受体）	-	HPRD,BioGRID	11238109
CD46	MCP \| MGC26544 \| MIC10 \| TLX \| TRA2.10	CD46分子，补体调节蛋白	亲和力捕获 - 韦斯特恩	Biogrid	10741407
CD53	MOX44 \| TSPAN25	CD53分子	-	HPRD,BioGRID	11959120
CD59	16.3A5 \| 1F5 \| EJ16 \| EJ30 \| EL32 \| FLJ38134 \| FLJ92039 \| G344 \| HRF-20 \| HRF20 \| MAC-IP \| MACIF \| MEM43 \| MGC2354 \| MIC11 \| MIN1 \| MIN2 \| MIN3 \| MIRL \| MSK21 \| p18-20	CD59分子，补体调节蛋白	-	HPRD	1377690
CD63	LAMP-3 \| ME491 \| MLA1 \| OMA81H \| TSPAN30	CD63 molecule	-	HPRD,BioGRID	8630057\|11204565 \|12175627
CD81	S5.7 \| TAPA1 \| TSPAN28	CD81分子	-	HPRD	12036870
CD81	S5.7 \| TAPA1 \| TSPAN28	CD81分子	亲和力捕获 - 韦斯特恩共同分级	Biogrid	8630057\|9804823
CD82	4F9 \| C33 \| GR15 \| IA4 \| KAI1 \| R2 \| SAR2 \| ST6 \| TSPAN27	CD82分子	亲和力捕获 - 韦斯特恩	Biogrid	15492270
IGSF8	CD316 \| CD81P3 \| EWI2 \| PGRL	免疫球蛋白超家族，成员8	-	HPRD,BioGRID	11504738
itga3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	整合素，α3（抗原CD49C，alpha 3的VLA-3受体亚基）	-	HPRD,BioGRID	10065872\|10694273
itga5	CD49E \|fnra \|VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	-	HPRD,BioGRID	10065872
ITGB1	CD29 \|fnrb \|GPIIA \|MDF2 \|MSK12 \|vla-beta \|vlab	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	亲和力捕获 - 韦斯特恩	Biogrid	8630057\|12175627
KIT	c-kit \|CD117 \|PBT \|scfr	v-kit Hardy-Zuckerman 4猫肉瘤病毒oncogene homolog	-	HPRD,BioGRID	12036870
prkca	AAG6 \|MGC129900 \|MGC129901 \|PKC-Alpha \|PKCA \|Prkaca	protein kinase C, alpha	-	HPRD,BioGRID	11325968
PTGFRN	CD315 \| CD9P-1 \| EWI-F \| FLJ11001 \| FPRP \| KIAA1436 \| SMAP-6	prostaglandin F2 receptor negative regulator	-	HPRD,BioGRID	11087758\|11278880
serpinh1	astp3 \|CBP1 \|CBP2 \|HSP47 \|Pig14 \|PPROM \|RA-A47 \|serpinh2 \|GP46	Serpin肽酶抑制剂，进化枝H（热休克蛋白47），成员1（胶原蛋白结合蛋白1）	-	HPRD,BioGRID	10227388
tSPAN4	nag-2 \|nag2 \|四翼\|TM4SF7 \|TSPAN-4	四翼烷蛋白4	-	HPRD,BioGRID	9360996

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG造血细胞谱系	88	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4整合素途径	46	35	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集	208	138	All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP	41	27	All SZGR 2.0 genes in this pathway
Korkola绒毛膜瘤	6	5	All SZGR 2.0 genes in this pathway
Korkola Seminoma UP	44	27	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP	59	38	All SZGR 2.0 genes in this pathway
渡边结肠癌MSI与MSS DN	81	42	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP	183	119	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
DAVICIONI横纹肌肉瘤PAX FOXO1融合起来	64	37	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
vecchi胃癌早期	430	232	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合8D DN的Takeda目标	205	127	All SZGR 2.0 genes in this pathway
tAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN	142	90	All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN	362	238	All SZGR 2.0 genes in this pathway
Lee神经Crest干细胞DN	118	79	All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化Kras DN	142	95	All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 65 UP	22	13	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
Landis Erbb2乳腺肿瘤324向上	150	93	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
Johansson神经胶质作用是PDGFB	58	44	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN	62	44	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌	358	245	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM1	229	137	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
LE EGR2目标DN	108	84	All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS	29	20	All SZGR 2.0 genes in this pathway
tARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK	169	111	All SZGR 2.0 genes in this pathway
Tenedini Megakaryocyte标记	66	48	All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn	546	351	All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者	555	346	All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞	293	193	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
布鲁诺造血	66	48	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
Sesto对UV C4的反应	20	14	All SZGR 2.0 genes in this pathway
Wang Smarce1靶向DN	371	218	All SZGR 2.0 genes in this pathway
Chiba对TSA的反应	52	33	All SZGR 2.0 genes in this pathway
Maclachlan BRCA1靶向DN	16	12	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP	78	48	All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP	37	31	All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS	108	71	All SZGR 2.0 genes in this pathway
Gerhold脂肪形成DN	64	44	All SZGR 2.0 genes in this pathway
Lee衰老的新皮层	89	59	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN	106	68	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
江缺氧正常	311	205	All SZGR 2.0 genes in this pathway
王顺铂响应和XPC向上	202	115	All SZGR 2.0 genes in this pathway
Han Jnk Singaling DN	39	27	All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR	74	47	All SZGR 2.0 genes in this pathway
肺癌和成纤维细胞的钟分泌组	132	93	All SZGR 2.0 genes in this pathway
Heller HDAC靶向	317	208	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN	154	101	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上	863	514	All SZGR 2.0 genes in this pathway
Mitsiades对aplidin DN的反应	249	165	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
MATZUK FERTILIZATION	8	5	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
CONRAD STEM CELL	39	27	All SZGR 2.0 genes in this pathway
王肿瘤的侵入性DN	210	128	All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN	252	155	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
Rutella对HGF的反应	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
VANASSE BCL2靶向DN	74	50	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
Hinata NFKB靶向角质形成细胞	91	63	All SZGR 2.0 genes in this pathway
Hinata NFKB靶向成纤维细胞	84	60	All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN	75	61	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM RISK UP	24	14	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MILI假足趋化性DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病	181	106	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP	101	66	All SZGR 2.0 genes in this pathway
村上紫外线响应1小时	17	10	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP	307	182	All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN	50	24	All SZGR 2.0 genes in this pathway
Kim所有疾病少突胶质细胞编号corr up	756	494	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
figueroa aml甲基化簇1	125	61	All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN	213	127	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3	430	288	All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS	62	35	All SZGR 2.0 genes in this pathway
Delpuech FOXO3靶向	68	49	All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN	1080	713	All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN	784	464	All SZGR 2.0 genes in this pathway
Rattenbacher由Celf1绑定	467	251	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族	target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-370	19	25	1A	HSA-MIR-370^brain	GCCUGCUGGGGUGGAACCUGG

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:CD9