SZGR2 - Beplay体育中心

Summary？

基因	93
象征	ACVR2B
Synonyms	ACTRIIB\|ActR-IIB\|HTX4
Description	苯丙酸诺龙一个衰退ptor type 2B
Reference	MIM：602730\|HGNC：HGNC：174\|Ensembl:ENSG00000114739\|HPRD：04106\|Vega:OTTHUMG00000131291
基因类型	蛋白质编码
Map location	3P22
Pascal p-value	2.88e-4
Sherlock p-value	0.461
主持人	Cerebellar Hemisphere Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.006

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	QVALUE	EQTL类型
RS16829545	CHR2	151977407	ACVR2B	93	0.04	反式
RS10473751		0	ACVR2B	93	0.17	反式
rs16955618	CHR15	29937543	ACVR2B	93	0.18	反式

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
去：0000287	镁离子结合	IEA		-
GO:0004872	受体活性	IEA		-
去：0005524	ATP binding	IEA		-
GO：0016740	转移酶活性	IEA		-
GO：0019838	growth factor binding	IPI		14517293
GO：0016362	activin receptor activity, type II	TAS		8622651
GO：0030145	锰离子结合	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006468	protein amino acid phosphorylation	IEA		-
去：0009952	anterior/posterior pattern formation	IMP		9916847
GO:0007165	信号转导	艾达		8622651
去：0030501	骨矿化的阳性调节	IMP		18436533
去：0030509	BMP信号通路	经验		15621726
去：0030509	BMP信号通路	艾达		18436533
GO：0032927	激活素受体信号通路的正调控	艾达		8622651
去：0045669	成骨细胞分化的阳性调节	IMP		18436533
GO:0045449	转录的调节	艾达		8622651
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005737	cytoplasm	艾达		14738881
去：0009986	cell surface	艾达		12493773
去：0005886	plasma membrane	经验		17356069
去：0005887	integral to plasma membrane	TAS		8161782

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ACVR1B	Actrib \|ACVRLK4 \|ALK4 \|SKR2	激活素A受体，类型Ib	-	HPRD	8612709 \| 8622651
ACVR1B	Actrib \|ACVRLK4 \|ALK4 \|SKR2	激活素A受体，类型Ib	-	HPRD,BioGRID	8612709
BMP6	VGR \| VGR1	骨形态发生蛋白6	亲和力捕获 - 韦斯特恩	Biogrid	10504300
BMP7	OP-1	骨形态发生蛋白7	-	HPRD,BioGRID	9748228
工程	CD105 \|结束\|FLJ41744 \|HHT1 \|ORW \|ORW1	内聚物	亲和力捕获 - 韦斯特恩	Biogrid	9872992
GDF11	BMP-11 \|BMP11	growth differentiation factor 11	-	HPRD,BioGRID	10391213
GDF5	BMP14 \|CDMP1 \|lap4 \|SYNS2	生长分化因子5	-	HPRD,BioGRID	8702914
IGSF1	IgCD1 \|IGDC1 \|INHBP \|KIAA0364 \|MGC75490 \|PGSF2	免疫球蛋白超家族，成员1	-	HPRD	11266516
INHBA	EDF \| FRP	抑制素，βa	-	HPRD,BioGRID	9202237
INHBB	MGC157939	抑制素，βb	-	HPRD,BioGRID	9202237
INHBC	IHBC	抑制素，βC	-	HPRD	12651901
MSTN	GDF8	Myostatin	-	HPRD,BioGRID	11459935
SNX1	HsT17379 \| MGC8664 \| SNX1A \| Vps5	排序Nexin 1	-	HPRD,BioGRID	11279102
SNX2	MGC5204 \|TRG-9	排序Nexin 2	亲和力捕获 - 韦斯特恩	Biogrid	11279102
SNX6	MGC3157 \|MSTP010 \|TFAF2	排序Nexin 6	-	HPRD,BioGRID	11279102
synj2bp	arip2 \|FLJ11271 \|FLJ41973 \|OMP25	synaptojanin 2 binding protein	-	HPRD,BioGRID	11882656\|15451561
TGFBRAP1	陷阱-1 \|陷阱1	转化生长因子，β受体相关蛋白1	-	HPRD	11278302

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG细胞因子细胞因子受体相互作用	267	161	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
PID ALK1途径	26	21	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
淋巴结的反应组信号传导	18	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP	23	15	All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病	368	234	All SZGR 2.0 genes in this pathway
Horiuchi WTAP靶向	306	188	All SZGR 2.0 genes in this pathway
Odonnell TFRC靶向DN	139	76	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3	48	31	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
里克曼肿瘤区分良好，而不是很差	236	139	All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标	893	528	All SZGR 2.0 genes in this pathway
由HPV31 DN永生	65	45	All SZGR 2.0 genes in this pathway
su胎盘	30	18	All SZGR 2.0 genes in this pathway
Martinez RB1靶向DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向DN	591	366	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
li诱导了自然杀手DN	116	83	All SZGR 2.0 genes in this pathway
Bruins通过TP53组A的UVC响应	898	516	All SZGR 2.0 genes in this pathway
拉菲尔Vegfa的目标	9	8	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
Let-7/98	1456	1462	1a	hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				HSA-MIR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
				hsa-let-7a^brain	ugagguaguaguauauaguu
				hsa-let-7b^brain	ugagguaguagguuguguguguu
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	ugagguaggagguuauauagu
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				HSA-MIR-98^brain	ugagguaaguuguauuguu
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	ugagguaguugugugugugcugu
mir-101	214	220	1a	hsa-miR-101	uacaguacugauaacugaag
mir-103/107	402	409	1A，M8	hsa-miR-103^brain	agcagcauuguacggcuauga
mir-103/107	402	409	1A，M8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-124/506	7202	7208	M8	hsa-miR-506	uaaggcacccuucugugaguaga
miR-124/506	7202	7208	M8	HSA-MIR-124^brain	UAAGGCACGCGGUGAAUGCC
mir-132/212	435	442	1A，M8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
mir-132/212	435	442	1A，M8	HSA-MIR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-138	199	205	1a	HSA-MIR-138^brain	AGCUGGUGUUGUGAAUC
miR-144	214	220	1a	HSA-MIR-144	UACAGUAUAGAUGAUGUACUAG
mir-148/152	9664	9670	M8	HSA-MIR-148A	ucagugcacuacaacuuugu
				HSA-MIR-152^brain	UCAGUGCAUGACACUUGGG
				HSA-MIR-148B	ucagugcaucacacaacuuugu
miR-15/16/195/424/497	109	115	1a	HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
miR-181	9691	9698	1A，M8	HSA-MIR-181A^brain	AACAUUCAACGCUGUCGGUGAGU
				HSA-MIR-181B^SZ	aacauucauugcugucggggg
				HSA-MIR-181C^brain	AACAUUCAACCUGUCGGUGAGU
				HSA-MIR-181D^brain	aacauucauuguugucggggguggguu
				HSA-MIR-181A^brain	AACAUUCAACGCUGUCGGUGAGU
				HSA-MIR-181B^SZ	aacauucauugcugucggggg
				HSA-MIR-181C^brain	AACAUUCAACCUGUCGGUGAGU
				HSA-MIR-181D^brain	aacauucauuguugucggggguggguu
miR-183	2491	2498	1A，M8	HSA-MIR-183	UAUGGCACUGGUAGAAUUCACUG
miR-186	2458	2464	1a	HSA-MIR-186	caaagaauuuugggcuu
miR-194	437	444	1A，M8	HSA-MIR-194	uguaacagcaacuccauga
miR-199	675	682	1A，M8	HSA-MIR-199A	CCCAGUGUUCAGACUACCUGUUC
miR-199	675	682	1A，M8	HSA-MIR-199B	cccaguguuuagacuaucuuc
miR-200bc/429	7589	7595	M8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
mir-203.1	7676	7682	M8	hsa-miR-203	ugaaauguuuaggaccacuag
mir-214	8016	8022	M8	hsa-miR-214^brain	acagcaggcacagacaggcag
mir-221/222	2577	2584	1A，M8	hsa-miR-221^brain	agcuacauugucugugggggguc
mir-221/222	2577	2584	1A，M8	hsa-miR-222^brain	agcuacaucuggcuacugggucuc
miR-23	9688	9694	1a	HSA-MIR-23A^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	9688	9694	1a	HSA-MIR-23B^brain	AUCACAUUGCCAGGGAUUACC
miR-26	5893	5899	1a	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	5893	5899	1a	HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
mir-320	2468	2474	1a	hsa-miR-320	aaaagcugggugagaggggcgaa
mir-320	2468	2474	1a	hsa-miR-320	aaaagcugggugagaggggcgaa
miR-324-5p	7318	7324	1a	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGU
mir-346	9493	9499	1a	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
mir-369-3p	150	156	1a	hsa-miR-369-3p	aauauacaugguugaucuuu
mir-369-3p	150	156	1a	hsa-miR-369-3p	aauauacaugguugaucuuu
miR-370	240	246	M8	HSA-MIR-370^brain	gccugggggguggaaccugg
miR-374	150	157	1A，M8	HSA-MIR-374	uuauaauacaAccugauaagug
miR-374	150	157	1A，M8	HSA-MIR-374	uuauaauacaAccugauaagug
miR-375	6288	6294	1a	HSA-MIR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-377	9711	9718	1A，M8	HSA-MIR-377	aucacacaaaggaacuuuuugu
miR-381	8998	9005	1A，M8	HSA-MIR-381	uauacaagggcaagcucucugu
miR-381	8998	9005	1A，M8	HSA-MIR-381	uauacaagggcaagcucucugu
miR-384	391	397	1a	HSA-MIR-384	auuccuagaaauuguucaua
mir-410	1488	1494	1a	hsa-miR-410	aauauaacacagauggcugu
mir-410	1488	1494	1a	hsa-miR-410	aauauaacacagauggcugu
miR-485-5p	293	299	1a	hsa-miR-485-5p	aggcuggccgugaugauuc
mir-503	109	115	1a	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
mir-539	8204	8210	M8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
mir-9	7654	7660	1a	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:ACVR2B

Section I. Genetics and epigenetics annotation

eQTL annotation

第二节。转录组注释

一般基因表达（GTEX）

时间变化的基因表达（brainspan）

No co-expressed genes in brain regions

第三节。基因本体论注释

Section IV. Protein-protein interaction annotation

Section V. Pathway annotation

第六节。microRNA注释