Gene Page:KLF4

Summary？
基因 9314
象征 KLF4
Synonyms EZF|GKLF
Description Kruppel-like factor 4 (gut)
Reference MIM:602253|HGNC：HGNC：6348|Ensembl:ENSG00000136826|Vega：Otthumg00000020449
基因类型 蛋白质编码
Map location 9q31
Pascal p-value 0.045
Sherlock p-value 0.822
胎儿β 0.023
主持人 Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS1339760 Chr9 110750458 KLF4 9314 0.19 顺式
RS10218671 CHR1 158362552 KLF4 9314 0.11 反式
RS17006539 CHR1 219926844 KLF4 9314 0.15 反式
RS6712107 CHR2 14178653 KLF4 9314 0.04 反式
RS16861129 CHR2 14201738 KLF4 9314 0.04 反式
RS16861131 CHR2 14202085 KLF4 9314 0.04 反式
rs7589712 CHR2 14205064 KLF4 9314 0.12 反式
RS1038697 CHR2 18537074 KLF4 9314 0.01 反式
rs6718379 CHR2 18632808 KLF4 9314 0.08 反式
rs17535450 CHR2 39900012 KLF4 9314 0.04 反式
RS17038084 CHR2 85192280 KLF4 9314 0.15 反式
rs17498115 CHR2 85249294 KLF4 9314 0.02 反式
rs17616012 CHR2 167926783 KLF4 9314 0.03 反式
rs17616252 CHR2 167976691 KLF4 9314 0.04 反式
rs1691463 CHR3 84914366 KLF4 9314 2.156E-4 反式
RS394185 CHR3 84959076 KLF4 9314 0 反式
RS9873752 CHR3 85401647 KLF4 9314 0.16 反式
RS9288980 CHR3 112964991 KLF4 9314 2.866e-5 反式
RS1499898 CHR3 112974550 KLF4 9314 0.15 反式
RS3995908 CHR3 112998529 KLF4 9314 2.866e-5 反式
rs7652801 CHR3 113008605 KLF4 9314 2.866e-5 反式
rs7625829 CHR3 113103743 KLF4 9314 5.127E-4 反式
RS4419353 CHR3 113254936 KLF4 9314 0 反式
RS9813633 CHR3 113908225 KLF4 9314 0.13 反式
RS2922180 CHR3 125280472 KLF4 9314 0.01 反式
RS2976809 CHR3 125451738 KLF4 9314 0.02 反式
rs9917710 CHR3 176280218 KLF4 9314 1.132E-6 反式
rs16854290 CHR4 42384014 KLF4 9314 0.04 反式
rs16854296 CHR4 42384362 KLF4 9314 0.04 反式
RS4241605 CHR4 78161505 KLF4 9314 0.02 反式
rs4241606 CHR4 78161919 KLF4 9314 0.05 反式
rs313946 CHR4 113975904 KLF4 9314 0.14 反式
rs16894149 CHR5 61013724 KLF4 9314 6.594E-4 反式
rs6449550 CHR5 61034312 KLF4 9314 6.656E-4 反式
rs17056435 CHR5 158453782 KLF4 9314 0 反式
RS9313797 CHR5 158465457 KLF4 9314 0.19 反式
rs17056474 CHR5 158468105 KLF4 9314 0.19 反式
rs2294262 CHR6 16108966 KLF4 9314 0.19 反式
rs16883859 CHR6 20474617 KLF4 9314 0.11 反式
rs16883862 CHR6 20474766 KLF4 9314 0.11 反式
rs12528414 CHR6 38404800 KLF4 9314 0.1 反式
rs6939897 CHR6 67913123 KLF4 9314 0.12 反式
RS6455226 CHR6 67930295 KLF4 9314 0.06 反式
RS16868852 CHR6 70980333 KLF4 9314 0.05 反式
rs2064428 CHR6 85067126 KLF4 9314 1.696E-4 反式
rs9489379 CHR6 118739603 KLF4 9314 0.16 反式
RS6903632 CHR6 118783045 KLF4 9314 0.16 反式
RS12207554 CHR6 118860704 KLF4 9314 0.16 反式
RS9489468 CHR6 118935681 KLF4 9314 0.04 反式
rs7800937 CHR7 143093306 KLF4 9314 0.15 反式
RS2199402 CHR8 9201002 KLF4 9314 7.47E-4 反式
RS2169384 CHR8 9216985 KLF4 9314 7.642E-4 反式
RS1381350 CHR8 9217194 KLF4 9314 2.163E-4 反式
RS7841407 CHR8 9243427 KLF4 9314 3.308E-5 反式
rs2739726 CHR8 17998576 KLF4 9314 0.06 反式
RS2954041 CHR8 32522625 KLF4 9314 0.1 反式
rs2976526 CHR8 32574650 KLF4 9314 0.1 反式
rs2975504 CHR8 32578998 KLF4 9314 0.1 反式
RS7045470 Chr9 11756233 KLF4 9314 0.14 反式
RS7850851 Chr9 37928770 KLF4 9314 0.04 反式
RS998410 Chr9 117622673 KLF4 9314 0.06 反式
RS9423711 Chr10 2574802 KLF4 9314 0.02 反式
rs748375 Chr10 33440178 KLF4 9314 0 反式
RS7081666 Chr10 47673800 KLF4 9314 0.16 反式
rs11199997 Chr10 85456823 KLF4 9314 0.05 反式
RS11820030 Chr11 76133564 KLF4 9314 0.02 反式
RS17134872 Chr11 76139845 KLF4 9314 0.02 反式
RS10751255 0 KLF4 9314 0.07 反式
rs11236774 Chr11 76234952 KLF4 9314 0.02 反式
RS2305164 CHR12 365649 KLF4 9314 0.1 反式
rs4149623 CHR12 6450577 KLF4 9314 0.01 反式
rs2856339 CHR12 11906818 KLF4 9314 0.12 反式
RS10747972 0 KLF4 9314 0.16 反式
rs11112163 CHR12 105072508 KLF4 9314 0.04 反式
rs17080889 CHR13 20939135 KLF4 9314 0.07 反式
RS7995192 CHR13 50782598 KLF4 9314 0.02 反式
rs9529974 CHR13 72821935 KLF4 9314 0.08 反式
rs11840833 CHR13 94378306 KLF4 9314 0.07 反式
RS10142086 CHR14 35135892 KLF4 9314 0.03 反式
RS10149864 CHR14 86719683 KLF4 9314 0.14 反式
RS2093759 CHR14 97171024 KLF4 9314 0.01 反式
rs17244419 CHR14 97171074 KLF4 9314 3.175E-4 反式
rs4147419 CHR15 35030570 KLF4 9314 0.09 反式
RS2249982 CHR15 70236349 KLF4 9314 0.08 反式
rs939043 CHR15 70236428 KLF4 9314 0.01 反式
RS13380712 CHR16 25601181 KLF4 9314 0.18 反式
rs17294918 CHR16 52717122 KLF4 9314 0.03 反式
rs16940550 CHR18 13442256 KLF4 9314 0.07 反式
RS9949772 CHR18 31042632 KLF4 9314 0.03 反式
rs4987765 CHR18 60905021 KLF4 9314 0.04 反式
RS11873703 CHR18 61448702 KLF4 9314 8.902E-4 反式
RS6017989 CHR20 45329846 KLF4 9314 0.15 反式
RS6095741 CHR20 48666589 KLF4 9314 0.01 反式
rs369613 CHR22 22380717 KLF4 9314 0.04 反式
RS410285 CHR22 22381767 KLF4 9314 0.04 反式
rs9627184 CHR22 48284887 KLF4 9314 0.12 反式
RS5768143 CHR22 48307043 KLF4 9314 0.12 反式
RS5768165 CHR22 48318197 KLF4 9314 1.499E-6 反式
RS5768168 CHR22 48319334 KLF4 9314 1.499E-6 反式
rs5768173 CHR22 48321475 KLF4 9314 1.499E-6 反式
RS1883665 Chrx 17650382 KLF4 9314 0.04 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
npat 0.92 0.93
ZRANB1 0.92 0.94
NUP153 0.92 0.94
MORC3 0.92 0.93
ZZZ3 0.92 0.93
CKAP5 0.92 0.93
N4BP1 0.91 0.94
KIAA0947 0.91 0.94
Ctr9 0.91 0.92
Cul4a 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
AF347015.31 -0.76 -0.83
FXYD1 -0.76 -0.83
MT-CO2 -0.76 -0.82
ifi27 -0.75 -0.82
HIGD1B -0.74 -0.83
AF347015.33 -0.72 -0.78
AF347015.21 -0.72 -0.84
AF347015.8 -0.71 -0.81
AF347015.27 -0.71 -0.77
mt-cyb -0.71 -0.78

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
Reactome糖尿病途径 133 91 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 16 11 All SZGR 2.0 genes in this pathway
白色脂肪细胞分化的Reactome转录调节 72 53 All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤DN 136 86 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN 463 290 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨型性白血病DN 116 79 All SZGR 2.0 genes in this pathway
Casorelli apl Secondary vs de从头上升 39 25 All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病 368 234 All SZGR 2.0 genes in this pathway
Horiuchi WTAP靶向 306 188 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞 233 161 All SZGR 2.0 genes in this pathway
Gargalovic对氧化磷脂的反应黄色 32 25 All SZGR 2.0 genes in this pathway
Bilban B Cll LPL DN 42 25 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向DN 240 171 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 64 46 All SZGR 2.0 genes in this pathway
刘cdx2靶向 36 22 All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 70 43 All SZGR 2.0 genes in this pathway
GESERICK TERT TARGETS DN 21 16 All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
Markey RB1慢性洛夫 115 78 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 67 45 All SZGR 2.0 genes in this pathway
Landis Erbb2乳腺肿瘤65 DN 37 22 All SZGR 2.0 genes in this pathway
Landis Erbb2乳腺肿瘤324 DN 149 93 All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment 536 340 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
Mattioli多发性骨髓瘤，有14q32易位 36 25 All SZGR 2.0 genes in this pathway
Seitz肿瘤转化通过8p删除 73 47 All SZGR 2.0 genes in this pathway
ETS1和SP100 DN的Yordy倒数调节 87 48 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌 358 245 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 69 40 All SZGR 2.0 genes in this pathway
Schlesinger甲基化的癌症 88 64 All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧 156 106 All SZGR 2.0 genes in this pathway
通过HIF1A DN的缺氧总缺氧 110 78 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142 104 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
Ingram SHH目标 127 79 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
gotzmann上皮到间充质过渡dn 206 136 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
阿米特血清反应120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1 vs CD2 UP 66 47 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 13Q14 DELETION 24 18 All SZGR 2.0 genes in this pathway
HOXA9和MEIS1 DN的HESS目标 77 48 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 86 67 All SZGR 2.0 genes in this pathway
量缺氧 98 71 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
伯顿成年时期峰值2小时 51 36 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
杰克逊DNMT1靶向 77 57 All SZGR 2.0 genes in this pathway
盖斯对dsrna的响应 38 29 All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞 681 420 All SZGR 2.0 genes in this pathway
伯顿成生成9 92 59 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
海勒被甲基化沉默 282 183 All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性 578 341 All SZGR 2.0 genes in this pathway
Iwanaga癌变由Kras Pten DN 353 226 All SZGR 2.0 genes in this pathway
iwanaga癌变由KRAS DN 120 81 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
CONRAD STEM CELL 39 27 All SZGR 2.0 genes in this pathway
WU被膀胱癌中的甲基化沉默 55 42 All SZGR 2.0 genes in this pathway
甜肺癌Kras DN 435 289 All SZGR 2.0 genes in this pathway
张TLX目标36hr 221 150 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
张TLX目标 108 78 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
Schoen NFKB信号 34 26 All SZGR 2.0 genes in this pathway
fontaine卵泡甲状腺腺瘤DN 68 45 All SZGR 2.0 genes in this pathway
fontaine乳头状甲状腺癌 66 38 All SZGR 2.0 genes in this pathway
Uzonyi对白三烯和凝血酶的反应 37 26 All SZGR 2.0 genes in this pathway
由MYC DN监管 253 192 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
钱德兰转移DN 306 191 All SZGR 2.0 genes in this pathway
么时间响应黄体酮集群5 30 22 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3 430 288 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 112 65 All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162 103 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway