Gene Page:CNOT8

Summary?
GeneID 9337
Symbol CNOT8
Synonyms CAF1|CALIF|Caf1b|POP2|hCAF1
Description CCR4-NOT transcription complex subunit 8
Reference MIM:603731|HGNC:HGNC:9207|Ensembl:ENSG00000155508|HPRD:07225|Vega:OTTHUMG00000130192
Gene type protein-coding
Map location 5q31-q33
Pascal p-value 0.168
Sherlock p-value 0.264
Fetal beta 0.953
DMG 1 (# studies)
eGene Caudate basal ganglia
Cortex
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg18632102 5 154238496 CNOT8 4.04E-8 -0.01 1.14E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17116417 chr5 154145473 CNOT8 9337 0.08 cis
rs816718 chr5 154184147 CNOT8 9337 0.03 cis
rs2688201 chr5 154252772 CNOT8 9337 0.08 cis
rs17116534 chr5 154254817 CNOT8 9337 0.05 cis
rs2544880 chr5 154265118 CNOT8 9337 0.11 cis
rs1035368 chr5 154308306 CNOT8 9337 0.08 cis
rs348752 chr5 154324528 CNOT8 9337 0.04 cis
rs1561519 chr2 35823020 CNOT8 9337 0.06 trans
rs7591339 chr2 35825597 CNOT8 9337 0.06 trans
rs7570146 chr2 35844751 CNOT8 9337 0.06 trans
rs1439691 chr2 35851281 CNOT8 9337 0.06 trans
rs1944366 chr18 52713130 CNOT8 9337 0.03 trans
rs12326929 chr18 70864592 CNOT8 9337 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception我们eks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BUB3 0.92 0.90
H2AFY 0.92 0.89
CSTF2 0.92 0.91
POLDIP3 0.92 0.91
ALDH18A1 0.91 0.90
USP39 0.91 0.89
SFRS1 0.91 0.89
TRA2B 0.91 0.88
RFWD3 0.90 0.90
TH1L 0.90 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.70 -0.84
MT-CO2 -0.69 -0.84
AF347015.33 -0.69 -0.82
AF347015.31 -0.68 -0.82
AF347015.8 -0.67 -0.83
FXYD1 -0.67 -0.80
MT-CYB -0.66 -0.80
C5orf53 -0.66 -0.71
S100B -0.64 -0.75
AF347015.21 -0.64 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003676 nucleic acid binding IEA -
GO:0003700 transcription factor activity NAS 10036195
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去:0006355 regulation of transcription, DNA-dependent NAS 10036195
GO:0006350 transcription IEA -
GO:0008285 negative regulation of cell proliferation TAS 9820826
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IDA 11256614
GO:0005634 nucleus NAS 10036195
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RNA DEGRADATION 59 37 所有SZGR 2.0基因通路
REACTOME DEADENYLATION OF MRNA 22 14 所有SZGR 2.0基因通路
REACTOME METABOLISM OF MRNA 284 128 所有SZGR 2.0基因通路
REACTOME DEADENYLATION DEPENDENT MRNA DECAY 48 29 所有SZGR 2.0基因通路
REACTOME METABOLISM OF RNA 330 155 所有SZGR 2.0基因通路
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 所有SZGR 2.0基因通路
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 66 42 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LIVE DN 384 220 所有SZGR 2.0基因通路
THUM SYSTOLIC HEART FAILURE UP 423 283 所有SZGR 2.0基因通路
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 所有SZGR 2.0基因通路
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE FIMA DN 284 156 所有SZGR 2.0基因通路
SEIDEN MET SIGNALING 19 16 所有SZGR 2.0基因通路
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 所有SZGR 2.0基因通路
PUJANA BRCA1 PCC NETWORK 1652 1023 所有SZGR 2.0基因通路
PUJANA ATM PCC NETWORK 1442 892 所有SZGR 2.0基因通路
BENPORATH NANOG TARGETS 988 594 所有SZGR 2.0基因通路
BENPORATH SOX2 TARGETS 734 436 所有SZGR 2.0基因通路
CHEOK RESPONSE TO HD MTX DN 24 18 所有SZGR 2.0基因通路
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 所有SZGR 2.0基因通路
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 67 33 所有SZGR 2.0基因通路
BROWNE HCMV INFECTION 48HR DN 504 323 所有SZGR 2.0基因通路
WEST ADRENOCORTICAL TUMOR UP 294 199 所有SZGR 2.0基因通路
YAGI AML WITH INV 16 TRANSLOCATION 422 277 所有SZGR 2.0基因通路
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 所有SZGR 2.0基因通路
BROWNE HCMV INFECTION 1HR DN 222 147 所有SZGR 2.0基因通路
JOHNSTONE PARVB TARGETS 3 DN 918 550 所有SZGR 2.0基因通路
RAO BOUND BY SALL4 ISOFORM B 517 302 所有SZGR 2.0基因通路
PECE MAMMARY STEM CELL DN 146 88 所有SZGR 2.0基因通路

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 259 266 1A,m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-200bc/429 1266 1272 1A hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-7 209 215 m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG