Gene Page:TM9SF2

Summary?
GeneID 9375
Symbol TM9SF2
Synonyms P76
Description transmembrane 9 superfamily member 2
Reference MIM:604678|HGNC:HGNC:11865|Ensembl:ENSG00000125304|HPRD:09198|Vega:OTTHUMG00000017272
Gene type protein-coding
Map location 13q32.3
Pascal p-value 0.722
Sherlock p-value 0.128
Fetal beta 0.967
DMG 1 (# studies)
eGene Cerebellar Hemisphere

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg26455579 13 100153786 TM9SF2 3.41E-8 -0.005 1.01E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GAB1 0.81 0.83
TMTC2 0.81 0.84
M6PRBP1 0.80 0.82
MEGF10 0.80 0.82
RFTN2 0.79 0.83
LASS2 0.79 0.84
CA14 0.78 0.77
MAGT1 0.78 0.82
COL4A5 0.78 0.82
PRR5L 0.78 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KLHL1 -0.39 -0.25
MPPED1 -0.34 -0.25
NEUROD6 -0.34 -0.28
DACT1 -0.34 -0.20
SATB2 -0.33 -0.22
RP9P -0.33 -0.44
AC011491.1 -0.33 -0.38
IER5L -0.33 -0.24
MEF2C -0.32 -0.25
RPRM -0.32 -0.27

Section III. Gene Ontology annotation

Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006810 transport TAS 9729438
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005768 endosome TAS 9729438
GO:0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 9729438
GO:0010008 endosome membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS UP 28 14 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
TOMLINS METASTASIS DN 20 16 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 78 51 All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND LD MTX UP 10 6 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193 112 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 146 88 All SZGR 2.0 genes in this pathway