Gene Page:CD28

Summary?
GeneID 940
Symbol CD28
Synonyms Tp44
Description CD28 molecule
Reference MIM: 186760|HGNC:HGNC:1653|Ensembl:ENSG00000178562|HPRD:01727|Vega:OTTHUMG00000132878
Gene type protein-coding
Map location 2q33
Pascal p-value 0.328
Fetal beta -0.11

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

部分即遗传学和表观遗传学注释


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C3AR1 0.76 0.69
ADORA3 0.76 0.69
LAPTM5 0.75 0.69
C3 0.75 0.70
ALOX5AP 0.75 0.70
TBXAS1 0.74 0.69
C1QC 0.73 0.68
CD53 0.73 0.67
LILRB4 0.72 0.66
LY86 0.71 0.62
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ANP32C -0.27 -0.33
AC005921.3 -0.26 -0.33
FBN3 -0.26 -0.16
SH3BP2 -0.26 -0.29
GJC1 -0.26 -0.18
TMC2 -0.26 -0.15
SCUBE1 -0.26 -0.21
AC010300.1 -0.26 -0.28
AC004017.1 -0.26 -0.13
SH2B2 -0.25 -0.30

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CD247 CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZ CD247 molecule - HPRD 8760790
CD4 CD4mut CD4 molecule - HPRD 7539755
CD80 CD28LG | CD28LG1 | LAB7 CD80 molecule CD80 interacts with CD28. BIND 15610849
CD80 CD28LG | CD28LG1 | LAB7 CD80 molecule - HPRD,BioGRID 7545666
CD86 B7-2 | B70 | CD28LG2 | LAB72 | MGC34413 CD86 molecule - HPRD 11021528
DUSP14 MKP-L | MKP6 dual specificity phosphatase 14 - HPRD,BioGRID 11123293
GRAP2 GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 GRB2-related adaptor protein 2 - HPRD,BioGRID 10820259
GRAP2 GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38 GRB2-related adaptor protein 2 GRAP2 (GRID) interacts with CD28. BIND 10820259
GRB2 ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 growth factor receptor-bound protein 2 - HPRD,BioGRID 7737275|8576157
|9694876
ITK EMT | LYK | MGC126257 | MGC126258 | PSCTK2 IL2-inducible T-cell kinase - HPRD 10586033
LCK YT16 | p56lck | pp58lck lymphocyte-specific protein tyrosine kinase - HPRD 10430626
LRRC23 LRPB7 leucine rich repeat containing 23 Reconstituted Complex BioGRID 1847722
NSF SKD2 N-ethylmaleimide-sensitive factor CD28 interacts with NSF. BIND 11680900
PIK3R1 GRB1 | p85 | p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) - HPRD,BioGRID 7737275|8621607
PLCG1 PLC-II | PLC1 | PLC148 | PLCgamma1 phospholipase C, gamma 1 - HPRD 8386518
PTPRC B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200 protein tyrosine phosphatase, receptor type, C - HPRD 1355979


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
桶G CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
桶G T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
桶G INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 48 36 All SZGR 2.0 genes in this pathway
桶G TYPE I DIABETES MELLITUS 44 38 All SZGR 2.0 genes in this pathway
桶G AUTOIMMUNE THYROID DISEASE 53 49 All SZGR 2.0 genes in this pathway
桶G SYSTEMIC LUPUS ERYTHEMATOSUS 140 100 All SZGR 2.0 genes in this pathway
桶G ALLOGRAFT REJECTION 38 34 All SZGR 2.0 genes in this pathway
桶G GRAFT VERSUS HOST DISEASE 42 31 All SZGR 2.0 genes in this pathway
桶G VIRAL MYOCARDITIS 73 58 All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY 12 11 All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY 11 8 All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY 21 14 All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY 29 21 All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 14 11 All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 14 11 All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY 19 14 All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY 21 18 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 33 29 All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 12 All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 32 26 All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY 11 10 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 22 18 All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 28 19 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA DN 52 30 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP 98 58 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP 51 29 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 65 44 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR 37 22 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196 137 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN 101 65 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 52 41 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway