Gene Page:HTRA3

Summary?
GeneID 94031
Symbol HTRA3
Synonyms Prsp|Tasp
Description HtrA serine peptidase 3
Reference MIM:608785|HGNC:HGNC:30406|Ensembl:ENSG00000170801|HPRD:08821|Vega:OTTHUMG00000090561
Gene type protein-coding
Map location 4p16.1
Pascal p-value 0.883
Fetal beta -1.556
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02577436 4 8271369 HTRA3 3.88E-5 -0.323 0.02 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11265452 chr1 160594237 HTRA3 94031 0.15 trans
rs17093190 chr20 34459279 HTRA3 94031 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FBXO41 0.92 0.91
SHANK1 0.91 0.91
IQSEC2 0.91 0.92
GRIN1 0.90 0.94
PIP5K1C 0.90 0.89
PITPNM2 0.90 0.93
PITPNM3 0.90 0.91
CBX6 0.90 0.87
SYN1 0.90 0.92
ZDHHC14 0.90 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB13 -0.49 -0.57
C21orf57 -0.47 -0.44
C9orf46 -0.46 -0.42
MYL12A -0.46 -0.52
RPS20 -0.44 -0.47
PECI -0.44 -0.45
GTF3C6 -0.43 -0.39
GNG11 -0.42 -0.43
RPS6 -0.42 -0.40
ANP32B -0.42 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0005515 protein binding IEA -
GO:0005520 insulin-like growth factor binding IEA -
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001558 regulation of cell growth IEA -
GO:0006508 proteolysis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN 41 29 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER HIGH RECURRENCE 49 31 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC 35 25 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER UP 38 21 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 59 35 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 75 48 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 932 938 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-144 917 923 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-218 956 962 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-24 748 754 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-30-5p 950 956 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-494 923 929 m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU