Gene Page:PEX16
Summary?
| GeneID | 9409 |
| Symbol | PEX16 |
| Synonyms | PBD8A|PBD8B |
| Description | peroxisomal biogenesis factor 16 |
| Reference | MIM:603360|HGNC:HGNC:8857|Ensembl:ENSG00000121680|HPRD:04526|Vega:OTTHUMG00000167005 |
| Gene type | protein-coding |
| Map location | 11p11.2 |
| Pascal p-value | 4.86E-4 |
| Sherlock p-value | 0.746 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PEX16 | chr11 | 45935423 | G | T | NM_004813 NM_057174 |
. . |
silent silent |
Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COX7A2 | 0.91 | 0.82 |
| C6orf125 | 0.90 | 0.81 |
| PTCD1 | 0.89 | 0.79 |
| MRPL52 | 0.89 | 0.76 |
| TIMM8B | 0.89 | 0.79 |
| NDUFB1 | 0.88 | 0.78 |
| UQCRQ | 0.87 | 0.74 |
| UBL5 | 0.87 | 0.81 |
| RP11-844E22.1 | 0.85 | 0.75 |
| NDUFB7 | 0.85 | 0.68 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MYH9 | -0.51 | -0.52 |
| MMRN2 | -0.48 | -0.54 |
| WNK1 | -0.47 | -0.56 |
| ECE1 | -0.46 | -0.44 |
| PHLPP1 | -0.46 | -0.50 |
| VWF | -0.45 | -0.53 |
| SLC6A6 | -0.45 | -0.46 |
| ARHGEF10 | -0.44 | -0.49 |
| PODXL | -0.44 | -0.39 |
| TENC1 | -0.44 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| DARWICHE皮肤肿瘤促进剂DN | 185 | 115 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW DN | 165 | 107 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH DN | 180 | 110 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA DN | 181 | 107 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| MCDOWELL ACUTE LUNG INJURY DN | 48 | 33 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |