Gene Page:HAND1

Summary?
GeneID 9421
Symbol HAND1
Synonyms Hxt|Thing1|bHLHa27|eHand
Description heart and neural crest derivatives expressed 1
Reference MIM:602406|HGNC:HGNC:4807|Ensembl:ENSG00000113196|HPRD:03871|Vega:OTTHUMG00000130193
Gene type protein-coding
Map location 5q33
Pascal p-value 0.015
Fetal beta -0.384
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25587535 5 153857846 HAND1 2.288E-4 -0.255 0.036 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26conception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAVS 0.89 0.88
NUP210 0.87 0.87
EIF2C1 0.87 0.82
SP1 0.87 0.84
MAML1 0.86 0.83
ZNF516 0.86 0.87
PDPR 0.85 0.84
FAM53B 0.84 0.86
CTDSP2 0.84 0.85
KIAA0355 0.84 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.48 -0.55
AF347015.21 -0.47 -0.64
C5orf53 -0.47 -0.50
RERGL -0.47 -0.61
IFI27 -0.46 -0.50
GMFG -0.46 -0.60
C1orf54 -0.46 -0.60
SYCP3 -0.46 -0.58
CARD16 -0.45 -0.56
MYL3 -0.45 -0.53

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity TAS 9931445
GO:0008134 transcription factor binding IEA -
GO:0016564 transcription repressor activity IEA -
GO:0042803 protein homodimerization activity IEA -
GO:0046982 protein heterodimerization activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0001525 angiogenesis IEA -
GO:0001707 mesoderm formation IEA -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0007507 heart development TAS 9931445
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA NFAT PATHWAY 56 45 所有SZGR2.0 genes in this pathway
MAHADEVAN IMATINIB RESISTANCE DN 20 11 所有SZGR2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK 74 44 所有SZGR2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 12HR 43 35 所有SZGR2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 所有SZGR2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5 94 59 所有SZGR2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 所有SZGR2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 所有SZGR2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185 114 所有SZGR2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 所有SZGR2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 所有SZGR2.0 genes in this pathway
伊万诺娃长期造血干细胞 302 191 所有SZGR2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 85 50 所有SZGR2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 所有SZGR2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 所有SZGR2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 所有SZGR2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 所有SZGR2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 所有SZGR2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 所有SZGR2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 744 751 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-196 684 691 1A,m8 hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-25/32/92/363/367 175 181 m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-33 431 437 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-335 803 810 1A,m8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-363 174 180 m8 hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA