SZGR2 - Beplay体育中心

Summary？

基因	9463
象征	Pick1
Synonyms	PICK\|PRKCABP
Description	protein interacting with PRKCA 1
Reference	MIM：605926\|HGNC：HGNC：9394\|Ensembl:ENSG00000100151\|HPRD:16176\|Vega:OTTHUMG00000151159
基因类型	蛋白质编码
Map location	22q13.1
Pascal p-value	0.318
Sherlock p-value	0.589
胎儿β	-0.319
主持人	Caudate basal ganglia 海马 Putamen basal ganglia Myers' cis & trans 元
Support	蛋白质聚类 G2Cdb.humanPSD G2Cdb.humanPSP 潜在的突触基因

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association	A combined odds ratio method (Sun等。2008), association studies	2	Link to SZGene
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关关键字的命中：3
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 2.7105

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS6596223	CHR5	134774309	Pick1	9463		0.14		反式
rs11912649	22	38415542	Pick1	ENSG00000100151.11	2.422e-6	0.02	-36776	gtex_brain_putamen_basal
RS1883471	22	38417510	Pick1	ENSG00000100151.11	1.929E-6	0.02	-34808	gtex_brain_putamen_basal
rs5995530	22	38419738	Pick1	ENSG00000100151.11	2。622E-6	0.02	-32580	gtex_brain_putamen_basal
RS713991	22	38426043	Pick1	ENSG00000100151.11	1.922E-6	0.02	-26275	gtex_brain_putamen_basal
RS3026670	22	38426774	Pick1	ENSG00000100151.11	1.64E-6	0.02	-25544	gtex_brain_putamen_basal
RS10427673	22	38427551	Pick1	ENSG00000100151.11	1.891E-6	0.02	-24767	gtex_brain_putamen_basal
rs8142174	22	38427963	Pick1	ENSG00000100151.11	1.561E-6	0.02	-24355	gtex_brain_putamen_basal
RS6519095	22	38431917	Pick1	ENSG00000100151.11	1.551E-6	0.02	-20401	gtex_brain_putamen_basal
rs12157609	22	38432277	Pick1	ENSG00000100151.11	1.242E-6	0.02	-20041	gtex_brain_putamen_basal
RS4821730	22	38441587	Pick1	ENSG00000100151.11	8.873E-7	0.02	-10731	gtex_brain_putamen_basal
RS4821731	22	38445214	Pick1	ENSG00000100151.11	9.399E-7	0.02	-7104	gtex_brain_putamen_basal
RS5756890	22	38445400	Pick1	ENSG00000100151.11	1.083E-6	0.02	-6918	gtex_brain_putamen_basal
RS760973	22	38447266	Pick1	ENSG00000100151.11	9.684e-7	0.02	-5052	gtex_brain_putamen_basal
RS4384887	22	38447365	Pick1	ENSG00000100151.11	1.12E-6	0.02	-4953	gtex_brain_putamen_basal
RS742395	22	38447444	Pick1	ENSG00000100151.11	9.21E-7	0.02	-4874	gtex_brain_putamen_basal
rs2413493	22	38448295	Pick1	ENSG00000100151.11	1.424E-6	0.02	-4023	gtex_brain_putamen_basal
RS4821733	22	38449394	Pick1	ENSG00000100151.11	2。354E-6	0.02	-2924	gtex_brain_putamen_basal
。	22	38449820	Pick1	ENSG00000100151.11	2.179E-6	0.02	-2498	gtex_brain_putamen_basal
RS5756894	22	38450136	Pick1	ENSG00000100151.11	2。332E-6	0.02	-2182	gtex_brain_putamen_basal
rs2018980	22	38450620	Pick1	ENSG00000100151.11	1.693E-6	0.02	-1698	gtex_brain_putamen_basal
RS742396	22	38452254	Pick1	ENSG00000100151.11	9.904e-7	0.02	-64	gtex_brain_putamen_basal
rs738442	22	38457329	Pick1	ENSG00000100151.11	2.578E-6	0.02	5011	gtex_brain_putamen_basal
rs738443	22	38458681	Pick1	ENSG00000100151.11	9.904e-7	0.02	6363	gtex_brain_putamen_basal
RS4821735	22	38458969	Pick1	ENSG00000100151.11	9.904e-7	0.02	6651	gtex_brain_putamen_basal
rs6000991	22	38460484	Pick1	ENSG00000100151.11	9.904e-7	0.02	8166	gtex_brain_putamen_basal
RS2076369	22	38463652	Pick1	ENSG00000100151.11	9.904e-7	0.02	11334	gtex_brain_putamen_basal
RS2076370	22	38463968	Pick1	ENSG00000100151.11	9.904e-7	0.02	11650	gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
CPNE6	0.60	0.68
Nelf	0.58	0.65
Prkcg	0.57	0.68
CD6	0.57	0.57
CNGB1	0.57	0.60
fibcd1	0.56	0.50
SUSD4	0.56	0.61
SYT17	0.55	0.62
galntl4	0.54	0.53
TTC7B	0.54	0.66

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
KIAA1949	-0.27	-0.22
RBMX2	-0.26	-0.39
ZNF193	-0.25	-0.18
FAM167B	-0.25	-0.39
tubb2b	-0.25	-0.26
SH2B2	-0.25	-0.34
AP000349.1	-0.25	-0.27
spata9	-0.25	-0.26
TMSB15A	-0.25	-0.28
ZNF300	-0.25	-0.13

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005102	receptor binding	ISS	神经递质（GO期限：4）	-
去：0005080	蛋白激酶C结合	ISS		-
GO:0008022	蛋白C末端结合	IPI		11343649
GO：0016887	ATPase activity	ISS		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0045161	神经元离子通道簇	TAS	neuron (GO term level: 11)	11343649
去：0007205	蛋白激酶C活性的激活	IDA		10623590
去：0006468	protein amino acid phosphorylation	ISS		-
去：0006605	蛋白质靶向	IEA		-
去：0006890	逆行囊泡介导的转运，高尔基	nas		10623590
GO:0015844	monoamine transport	IDA		11343649
GO:0043046	DNA methylation during gametogenesis	TAS		12138111
GO：0043113	receptor clustering	ISS		-
GO:0043045	DNA methylation during embryonic development	nas		12138111
Cellular component	去学期	证据	神经关键字	PubMed ID
GO：0042734	presynaptic membrane	IDA	神经元，轴突，突触（GO术语级别：5）	11343649
GO:0045202	突触	ISS	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
去：0005794	高尔基体	ISS		-
去：0005737	cytoplasm	IDA		11343649
去：0005739	mitochondrion	IEA		-
去：0005886	plasma membrane	IDA		11343649
GO：0048471	细胞质的核周区	ISS		-
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ACCN1	ACCN \| ASIC2 \| ASIC2a \| BNC1 \| BNaC1 \| MDEG \| hBNaC1	Amiloride敏感阳离子通道1，神经元	Pick1interacts with BNC1a.	绑定	11802773
ACCN1	ACCN \| ASIC2 \| ASIC2a \| BNC1 \| BNaC1 \| MDEG \| hBNaC1	Amiloride敏感阳离子通道1，神经元	-	HPRD	11739374
ACCN1	ACCN \| ASIC2 \| ASIC2a \| BNC1 \| BNaC1 \| MDEG \| hBNaC1	Amiloride敏感阳离子通道1，神经元	Pick1interacts with BNC1b.	绑定	11802773
ACCN2	asic \|asic1 \|asic1a \|BNAC2 \|HBNAC2	amiloride-sensitive cation channel 2, neuronal	Pick1与ASIC相互作用。	绑定	11802773
ACCN2	asic \|asic1 \|asic1a \|BNAC2 \|HBNAC2	amiloride-sensitive cation channel 2, neuronal	-	HPRD,BioGRID	11739374\|11802773 \|12578970
BNC1	BNC \| BSN1 \| HsT19447	basonuclin 1	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	11802773
BTG2	MGC126063 \| MGC126064 \| PC3 \| TIS21	BTG家庭，成员2	-	HPRD	11237868
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD,BioGRID	9883737
ERBB2	CD340 \| her - 2 \| her - 2 \| HER2 / neu \| neu \|天然气凝析液\|唯一1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD,BioGRID	11278603
erbb2ip	ERBIN \| LAP2	ERBB2相互作用蛋白	Two-hybrid	Biogrid	11278603
gria1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	-	HPRD,BioGRID	11891216
gria2	GLUR2 \| GLURB \| GluR-K2 \| HBGR2	glutamate receptor, ionotropic, AMPA 2	重构的复合物 Two-hybrid	Biogrid	11891216
gria3	GLUR-C \| GLUR-K3 \| GLUR3 \| GLURC \| MRX94	谷氨酸受体，离子营养，AMPA 3	重构的复合物 Two-hybrid	Biogrid	11891216
gria4	glur4 \|glur4c \|glurd	谷氨酸受体，离子营养，AMPA 4	重构的复合物 Two-hybrid	Biogrid	11891216
GRIK1	EAA3 \| EEA3 \| GLR5 \| GLUR5	谷氨酸受体，离子型，海藻酸盐1	-	HPRD	11891216
GRIK1	EAA3 \| EEA3 \| GLR5 \| GLUR5	谷氨酸受体，离子型，海藻酸盐1	-	HPRD,BioGRID	12597860
GRIK2	EAA4 \|Glr6 \|Gluk6 \|glur6 \|MGC74427 \|MRT6	谷氨酸受体，离子型，海藻酸盐2	-	HPRD,BioGRID	12597860
GRIK3	EAA5 \|Glr7 \|Glur7 \|glur7a	谷氨酸受体，离子型，海藻酸盐3	重构的复合物 Two-hybrid	Biogrid	11891216
GRM3	glur3 \|gprc1c \|mglur3 \|mglu3	glutamate receptor, metabotropic 3	重构的复合物 Two-hybrid	Biogrid	11891216
GRM7	FLJ40498 \| GLUR7 \| GPRC1G \| MGLUR7 \| mGlu7	glutamate receptor, metabotropic 7	Pick1interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between PICK1 from an unspecified species and human mGluR7b.	绑定	11891216
GRM7	FLJ40498 \| GLUR7 \| GPRC1G \| MGLUR7 \| mGlu7	glutamate receptor, metabotropic 7	亲和力捕获 - 韦斯特恩生化活动重构的复合物 Two-hybrid	Biogrid	11007882
LRP2BP	DKFZP761O0113 \|FLJ44965	LRP2结合蛋白	-	HPRD	12508107
Pick1	MGC15204 \|选择\|prkcabp	protein interacting with PRKCA 1	Pick1interacts with another PICK1.	绑定	11802773
prkca	AAG6 \|MGC129900 \|MGC129901 \|PKC-Alpha \|PKCA \|Prkaca	protein kinase C, alpha	亲和力捕获 - 韦斯特恩	Biogrid	11007882
prlhr	GPR10 \|gr3 \|MGC126539 \|MGC126541 \|prrpr	催乳素释放激素受体	亲和力捕获 - 韦斯特恩	Biogrid	11641419
SLC6A3	dat \|dat1	溶质载体家族6（神经递质转运蛋白，多巴胺），成员3	-	HPRD,BioGRID	11343649

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
反应组神经递质受体结合和突触后细胞中的下游传播	137	110	All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS	28	23	All SZGR 2.0 genes in this pathway
含有AMPA受体的GLUR2的Reactome贩运	16	11	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
彭亮氨酸剥夺	142	93	All SZGR 2.0 genes in this pathway
彭葡萄糖剥夺DN	169	112	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
Magrangeas多发性骨髓瘤Igll vs Iglk	42	24	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
TACI UP淋巴细胞的淋巴细胞成熟	92	58	All SZGR 2.0 genes in this pathway
zamora nos2靶向	69	41	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
McCabe Hoxc6靶向癌症	31	23	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
fontaine卵泡甲状腺腺瘤DN	68	45	All SZGR 2.0 genes in this pathway
fontaine乳头状甲状腺癌DN	80	53	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
Kasler HDAC7靶向1个	194	133	All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF	367	231	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-214	96	102	M8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:Pick1