Gene Page:ADAMTS2
年代ummary?
| GeneID | 9509 |
| 年代ymbol | ADAMTS2 |
| 年代ynonyms | ADAM-TS2|ADAMTS-2|ADAMTS-3|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI |
| Description | ADAM metallopeptidase with thrombospondin type 1 motif 2 |
| Reference | MIM:604539|HGNC:HGNC:218|Ensembl:ENSG00000087116|HPRD:05173|Vega:OTTHUMG00000130915 |
| Gene type | protein-coding |
| Map location | 5qter |
| Pascal p-value | 2.109 e-6 |
| Fetal beta | 1.355 |
| DMG | 2 (# studies) |
| eGene | Caudate basal ganglia Nucleus accumbens basal ganglia Putamen basal ganglia 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 4 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 4 |
| PMID:cooccur | High-throughput literature-search | 年代ystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.0276 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
年代ection I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | 年代tudy |
|---|---|---|---|---|---|---|---|
| cg00402222 | 5 | 178622572 | ADAMTS2 | 3.39E-5 | 0.565 | 0.019 | DMG:Wockner_2014 |
| cg27016106 | 5 | 178763771 | ADAMTS2 | 2.69E-4 | -0.427 | 0.038 | DMG:Wockner_2014 |
| cg15906761 | 5 | 178623035 | ADAMTS2 | 3.498E-4 | 0.418 | 0.042 | DMG:Wockner_2014 |
| cg09729848 | 5 | 178770998 | ADAMTS2 | 5E-8 | -0.016 | 1.33E-5 | DMG:Jaffe_2016 |
eQTL annotation
| 年代NP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs34095418 | 5 | 178593899 | ADAMTS2 | ENSG00000087116.9 | 1.52507E-6 | 0.05 | 178532 | gtex_brain_putamen_basal |
年代ection II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | 年代pearman's Correlation |
| IPO8 | 0.85 | 0.87 |
| NAT13 | 0.84 | 0.86 |
| NBN | 0.84 | 0.84 |
| COPB2 | 0.84 | 0.84 |
| TM9SF3 | 0.84 | 0.87 |
| MUDENG | 0.84 | 0.85 |
| PDZD8 | 0.84 | 0.86 |
| CLCN3 | 0.84 | 0.86 |
| LYSMD3 | 0.84 | 0.86 |
| CANX | 0.83 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | 年代pearman's Correlation |
| AF347015.21 | -0.61 | -0.56 |
| MT-CO2 | -0.60 | -0.60 |
| FXYD1 | -0.59 | -0.58 |
| IFI27 | -0.57 | -0.56 |
| AC018755.7 | -0.57 | -0.59 |
| HIGD1B | -0.57 | -0.57 |
| AF347015.31 | -0.55 | -0.57 |
| AF347015.8 | -0.55 | -0.56 |
| CSAG1 | -0.55 | -0.54 |
| AF347015.33 | -0.55 | -0.54 |
年代ection III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | TAS | 10417273 | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0008233 | peptidase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007283 | spermatogenesis | IEA | - | |
| GO:0051605 | protein maturation via proteolysis | IEA | - | |
| GO:0030199 | collagen fibril organization | IEA | - | |
| GO:0030324 | lung development | IEA | - | |
| GO:0030574 | collagen catabolic process | IEA | - | |
| GO:0043588 | skin development | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005578 | proteinaceous extracellular matrix | IEA | - |
年代ection V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME EXTRACELLULAR MATRIX ORGANIZATION | 87 | 42 | All SZGR 2.0 genes in this pathway |
| REACTOME COLLAGEN FORMATION | 58 | 31 | All SZGR 2.0 genes in this pathway |
| 年代ENGUPTA NASOPHARYNGEAL CARCINOMA UP | 294 | 178 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER ADVANCED VS EARLY UP | 175 | 120 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS F UP | 185 | 119 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| 年代CHAEFFER PROSTATE DEVELOPMENT 6HR UP | 176 | 115 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 16HR DN | 86 | 62 | All SZGR 2.0 genes in this pathway |
| DELASERNA MYOD TARGETS DN | 57 | 42 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| LEIN PONS MARKERS | 89 | 59 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOGONIA | 24 | 17 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATID DIFFERENTIATION | 37 | 26 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOZOA | 114 | 77 | All SZGR 2.0 genes in this pathway |
| WU ALZHEIMER DISEASE DN | 19 | 12 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 | 210 | 148 | All SZGR 2.0 genes in this pathway |
| ZEMBUTSU SENSITIVITY TO FLUOROURACIL | 17 | 8 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| 国外RB1增长目标 | 243 | 155 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| KIM GLIS2 TARGETS UP | 84 | 61 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |
| NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |