Gene Page:CD40
Summary?
| GeneID | 958 |
| Symbol | CD40 |
| Synonyms | Bp50|CDW40|TNFRSF5|p50 |
| Description | CD40 molecule |
| Reference | MIM:109535|HGNC:HGNC:11919|Ensembl:ENSG00000101017|HPRD:00178|Vega:OTTHUMG00000033053 |
| Gene type | protein-coding |
| Map location | 20q12-q13.2 |
| Pascal p-value | 0.003 |
| Fetal beta | -0.62 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LAPTM5 | 0.86 | 0.88 |
| C1QC | 0.83 | 0.84 |
| ADORA3 | 0.82 | 0.81 |
| CTSS | 0.80 | 0.80 |
| C3 | 0.80 | 0.79 |
| C3AR1 | 0.80 | 0.84 |
| FCGR3A | 0.80 | 0.77 |
| ITGB2 | 0.78 | 0.79 |
| NCKAP1L | 0.78 | 0.77 |
| TBXAS1 | 0.78 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC010300.1 | -0.31 | -0.38 |
| AC005921.3 | -0.31 | -0.44 |
| ZNF814 | -0.30 | -0.37 |
| RP9P | -0.29 | -0.41 |
| ANP32C | -0.29 | -0.29 |
| ANKRD36B | -0.28 | -0.38 |
| UPF3A | -0.28 | -0.32 |
| SCUBE1 | -0.28 | -0.20 |
| SH2D2A | -0.28 | -0.30 |
| ANKRD36 | -0.27 | -0.35 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CALR | CRT | FLJ26680 | RO | SSA | cC1qR | calreticulin | Affinity Capture-MS | BioGRID | 17353931 |
| CD40LG | CD154 | CD40L | HIGM1 | IGM | IMD3 | T-BAM | TNFSF5 | TRAP | gp39 | hCD40L | CD40 ligand | - | HPRD | 7516405|7543281 |10647992 |
| DDX3X | DBX | DDX14 | DDX3 | HLP2 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | Affinity Capture-MS | BioGRID | 17353931 |
| FBL | FIB | FLRN | RNU3IP1 | fibrillarin | Affinity Capture-MS | BioGRID | 17353931 |
| MS4A1 | B1 | Bp35 | CD20 | LEU-16 | MGC3969 | MS4A2 | S7 | membrane-spanning 4-domains, subfamily A, member 1 | - | HPRD,BioGRID | 9933087 |
| NCOA6 | AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP | nuclear receptor coactivator 6 | Reconstituted Complex | BioGRID | 10847592 |
| NSMAF | FAN | neutral sphingomyelinase (N-SMase) activation associated factor | - | HPRD | 10601289 |
| POLR2H | RPABC3 | RPB17 | RPB8 | hsRPB8 | polymerase (RNA) II (DNA directed) polypeptide H | Affinity Capture-MS | BioGRID | 17353931 |
| RFC5 | MGC1155 | RFC36 | replication factor C (activator 1) 5, 36.5kDa | Affinity Capture-MS | BioGRID | 17353931 |
| RIPK2 | CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2 | receptor-interacting serine-threonine kinase 2 | - | HPRD,BioGRID | 9642260 |
| RNF219 | C13orf7 | DKFZp686A01276 | DKFZp686N15250 | DKFZp686O03173 | FLJ13449 | FLJ25774 | ring finger protein 219 | Affinity Capture-MS | BioGRID | 17353931 |
| SGK1 | SGK | serum/glucocorticoid regulated kinase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| SLC30A7 | DKFZp686M0368 | ZNT7 | ZnT-7 | ZnTL2 | solute carrier family 30 (zinc transporter), member 7 | Affinity Capture-MS | BioGRID | 17353931 |
| SLC39A7 | D6S115E | D6S2244E | H2-KE4 | HKE4 | KE4 | RING5 | ZIP7 | solute carrier family 39 (zinc transporter), member 7 | Affinity Capture-MS | BioGRID | 17353931 |
| SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | Two-hybrid | BioGRID | 8906799 |
| TRAF1 | EBI6 | MGC:10353 | TNF receptor-associated factor 1 | - | HPRD | 7527023|10411888 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | - | HPRD,BioGRID | 10411888 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | CD40 interacts with TRAF2. | BIND | 10352240 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | - | HPRD | 7527023|7530216 |7533327|10984535 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid |
BioGRID | 7527023|9384571 |9990007|10984535 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | CD40 interacts with TRAF3. | BIND | 10352240 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | - | HPRD | 7527023|7533327 |10984535 |
| TRAF3IP2 | ACT1 | C6orf2 | C6orf4 | C6orf5 | C6orf6 | CIKS | DKFZp586G0522 | MGC3581 | TRAF3 interacting protein 2 | - | HPRD,BioGRID | 12089335 |
| TRAF5 | MGC:39780 | RNF84 | TNF receptor-associated factor 5 | - | HPRD,BioGRID | 8790348|9990007 |
| TRAF6 | MGC:3310 | RNF85 | TNF receptor-associated factor 6 | Reconstituted Complex | BioGRID | 9384571|9990007 |
| TRAF6 | MGC:3310 | RNF85 | TNF receptor-associated factor 6 | - | HPRD | 10075662|10411888 |
| TTRAP | AD022 | EAP2 | MGC111021 | MGC9099 | dJ30M3.3 | TRAF and TNF receptor associated protein | - | HPRD,BioGRID | 10764746 |
| TXN | DKFZp686B1993 | MGC61975 | TRX | TRX1 | thioredoxin | Affinity Capture-MS | BioGRID | 17353931 |
| TXNDC4 | ERP44 | KIAA0573 | thioredoxin domain containing 4 (endoplasmic reticulum) | Affinity Capture-MS | BioGRID | 17353931 |
| UGCGL1 | FLJ23671 | FLJ23796 | HUGT1 | UDP-glucose ceramide glucosyltransferase-like 1 | Affinity Capture-MS | BioGRID | 17353931 |
| USP15 | KIAA0529 | MGC131982 | MGC149838 | MGC74854 | UNPH4 | ubiquitin specific peptidase 15 | Affinity Capture-MS | BioGRID | 17353931 |
| XRCC5 | FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIV | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | - | HPRD,BioGRID | 10514012 |
| XRCC6 | CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA | X-ray repair complementing defective repair in Chinese hamster cells 6 | - | HPRD,BioGRID | 10514012 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG细胞因子细胞因子受体的相互作用 | 267 | 161 | All SZGR 2.0 genes in this pathway |
| KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | 102 | 88 | All SZGR 2.0 genes in this pathway |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | 48 | 36 | All SZGR 2.0 genes in this pathway |
| KEGG ASTHMA | 30 | 25 | All SZGR 2.0 genes in this pathway |
| KEGG AUTOIMMUNE THYROID DISEASE | 53 | 49 | All SZGR 2.0 genes in this pathway |
| KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | 140 | 100 | All SZGR 2.0 genes in this pathway |
| KEGG ALLOGRAFT REJECTION | 38 | 34 | All SZGR 2.0 genes in this pathway |
| KEGG PRIMARY IMMUNODEFICIENCY | 35 | 28 | All SZGR 2.0 genes in this pathway |
| KEGG VIRAL MYOCARDITIS | 73 | 58 | All SZGR 2.0 genes in this pathway |
| BIOCARTA ASBCELL PATHWAY | 12 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA BLYMPHOCYTE PATHWAY | 11 | 8 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CD40 PATHWAY | 15 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DC PATHWAY | 22 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TH1TH2 PATHWAY | 19 | 14 | All SZGR 2.0 genes in this pathway |
| SIG CD40PATHWAYMAP | 34 | 28 | All SZGR 2.0 genes in this pathway |
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 70 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| DEURIG T细胞PROLYMPHOCYTIC白血病 | 368 | 234 | All SZGR 2.0 genes in this pathway |
| NOJIMA SFRP2 TARGETS UP | 31 | 23 | All SZGR 2.0 genes in this pathway |
| HUMMEL BURKITTS LYMPHOMA DN | 15 | 10 | All SZGR 2.0 genes in this pathway |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN | 95 | 57 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS G UP | 238 | 135 | All SZGR 2.0 genes in this pathway |
| RAMJAUN APOPTOSIS BY TGFB1 VIA SMAD4 UP | 7 | 6 | All SZGR 2.0 genes in this pathway |
| KLEIN TARGETS OF BCR ABL1 FUSION | 45 | 34 | All SZGR 2.0 genes in this pathway |
| DIRMEIER LMP1 RESPONSE EARLY | 66 | 48 | All SZGR 2.0 genes in this pathway |
| DIRMEIER LMP1 RESPONSE LATE UP | 57 | 41 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM2 | 153 | 102 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM5 | 94 | 59 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| SHIN B CELL LYMPHOMA CLUSTER 9 | 19 | 13 | All SZGR 2.0 genes in this pathway |
| MORI LARGE PRE BII LYMPHOCYTE DN | 58 | 39 | All SZGR 2.0 genes in this pathway |
| MORI IMMATURE B LYMPHOCYTE UP | 53 | 35 | All SZGR 2.0 genes in this pathway |
| MORI MATURE B LYMPHOCYTE UP | 90 | 62 | All SZGR 2.0 genes in this pathway |
| MORI PLASMA CELL DN | 33 | 20 | All SZGR 2.0 genes in this pathway |
| KLEIN PRIMARY EFFUSION LYMPHOMA DN | 58 | 42 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| BASSO CD40 SIGNALING UP | 101 | 76 | All SZGR 2.0 genes in this pathway |
| LEE AGING NEOCORTEX UP | 89 | 59 | All SZGR 2.0 genes in this pathway |
| TSENG IRS1 TARGETS DN | 135 | 88 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| FOSTER TOLERANT MACROPHAGE DN | 409 | 268 | All SZGR 2.0 genes in this pathway |
| AMUNDSON GAMMA RADIATION RESISTANCE | 20 | 14 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| GALI TP53 TARGETS APOPTOTIC UP | 8 | 7 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| SEKI INFLAMMATORY RESPONSE LPS UP | 77 | 56 | All SZGR 2.0 genes in this pathway |
| LINDSTEDT DENDRITIC CELL MATURATION A | 67 | 52 | All SZGR 2.0 genes in this pathway |
| HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP | 70 | 49 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 ICP WITH H3K27ME3 | 74 | 46 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS CALB1 CORR DN | 37 | 20 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| PLASARI TGFB1 TARGETS 10HR UP | 199 | 143 | All SZGR 2.0 genes in this pathway |
| KRIEG KDM3A TARGETS NOT HYPOXIA | 208 | 107 | All SZGR 2.0 genes in this pathway |
| BOSCO INTERFERON INDUCED ANTIVIRAL MODULE | 78 | 48 | All SZGR 2.0 genes in this pathway |