Gene Page:AKAP12

Summary？
基因 9590
象征 AKAP12
Synonyms AKAP250 | SSECKS
Description A-kinase anchoring protein 12
Reference MIM:604698|HGNC：HGNC：370|Ensembl:ENSG00000131016|HPRD:05263|
基因类型 蛋白质编码
Map location 6Q24-Q25
pascal p-value 0.102
Sherlock p-value 0.306
胎儿β 0.844
DMG 3（＃研究）
主持人 Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 3
DMG：Nishioka_2013 全基因组DNA甲基化分析 作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。 3
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 3
表达 Meta-analysis of gene expression p值：1.602

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
cg12061236 6 15156086 AKAP12 6.6e-5 0.453 0.024 DMG：Wockner_2014
CG01555431 6 151562026 AKAP12 -0.025 0.32 DMG：Nishioka_2013
CG17543885 6 151562429 AKAP12 9.44e-11 -0.029 4.49e-7 DMG：JAFFE_2016

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS7584986 CHR2 184111432 AKAP12 9590 0.05 反式
rs16955618 chr15 29937543 AKAP12 9590 0.15 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene pearson's Correlation 斯皮尔曼的相关性
cacna2d1 0.83 0.89
ABI2 0.83 0.88
PCYOX1 0.82 0.87
ATP13A3 0.82 0.86
GNAQ 0.82 0.87
MARK1 0.82 0.88
ARFGEF1 0.81 0.86
NUP50 0.81 0.87
SOS1 0.81 0.87
exoc4 0.81 0.86
Top 10 negatively co-expressed genes
Gene pearson's Correlation 斯皮尔曼的相关性
FXYD1 -0.67 -0.74
AF347015.31 -0.65 -0.72
MT-CO2 -0.64 -0.72
AF347015.33 -0.63 -0.68
TLCD1 -0.63 -0.71
HSD17B14 -0.63 -0.69
HIGD1B -0.62 -0.71
AC021016.1 -0.62 -0.69
AF347015.8 -0.62 -0.71
TSC22D4 -0.62 -0.66

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0051018 protein kinase A binding TAS 10858453
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007186 G蛋白偶联受体蛋白信号通路 TAS 10858453
GO:0007165 信号转导 IEA -
去：0006605 蛋白质靶向 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005856 细胞骨架 IEA -
去：0005634 nucleus IDA 18029348
去：0005737 cytoplasm TAS 10858453
去：0005886 plasma membrane IDA 18029348

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
中村肿瘤区周围与中央 285 181 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
ginestier乳腺癌20q13扩增 119 66 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP 79 50 All SZGR 2.0 genes in this pathway
Bilban b cll lpl up 63 39 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 139 83 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧 130 85 All SZGR 2.0 genes in this pathway
Elvidge HIF1A和HIF2A靶向DN 104 72 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232 154 All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化Kras DN 142 95 All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS DN 14 14 All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应 770 415 All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa Forever DN转变 31 23 All SZGR 2.0 genes in this pathway
Landis Erbb2乳腺肿瘤324向上 150 93 All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变 394 258 All SZGR 2.0 genes in this pathway
ZIRN TRETINOIN RESPONSE WT1 UP 23 14 All SZGR 2.0 genes in this pathway
ZIRN维甲酸响应 21 13 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
XU HGF信令不通过Akt1 48hr向上 35 20 All SZGR 2.0 genes in this pathway
Dauer Stat3靶向 49 35 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌 358 245 All SZGR 2.0 genes in this pathway
KIM MYCN扩增靶向DN 103 59 All SZGR 2.0 genes in this pathway
TOMLINS PROSTATE CANCER DN 40 33 All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧 156 106 All SZGR 2.0 genes in this pathway
仅通过ELK3的高缺氧 33 18 All SZGR 2.0 genes in this pathway
Ingram SHH目标 127 79 All SZGR 2.0 genes in this pathway
WU细胞迁移 184 114 All SZGR 2.0 genes in this pathway
Amit EGF响应240 HELA 60 43 All SZGR 2.0 genes in this pathway
Amit EGF响应240 MCF10A 20 13 All SZGR 2.0 genes in this pathway
阿米特血清反应240 MCF10A 57 36 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 110 69 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
郭十六进制目标 81 54 All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞 293 193 All SZGR 2.0 genes in this pathway
DORSEY GAB2 TARGETS 31 17 All SZGR 2.0 genes in this pathway
Tavor Cebpa靶向 48 36 All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 45 33 All SZGR 2.0 genes in this pathway
马尔基尼trabectedin抗性 21 16 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
麦克道尔急性肺损伤 45 29 All SZGR 2.0 genes in this pathway
Lindvall因TERT DN永生 80 56 All SZGR 2.0 genes in this pathway
江缺氧正常 311 205 All SZGR 2.0 genes in this pathway
伯顿成生成9 92 59 All SZGR 2.0 genes in this pathway
Bild MYC致癌签名 206 117 All SZGR 2.0 genes in this pathway
Bild HRAS致癌特征 261 166 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
Lein Pons标记 89 59 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
Kyng环境压力反应 56 41 All SZGR 2.0 genes in this pathway
海勒被甲基化沉默 282 183 All SZGR 2.0 genes in this pathway
Heller HDAC靶向 317 208 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
伽玛辐射8G后的生存率不佳 95 62 All SZGR 2.0 genes in this pathway
华莱士前列腺癌DN 6 6 All SZGR 2.0 genes in this pathway
Iwanaga癌变由Kras Pten DN 353 226 All SZGR 2.0 genes in this pathway
Izadpanah干细胞脂肪与骨DN 108 68 All SZGR 2.0 genes in this pathway
Labbe Wnt3a靶向 112 71 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
Takeer吉西他滨抗性DN 122 84 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
甜肺癌Kras DN 435 289 All SZGR 2.0 genes in this pathway
4EBP1和4EBP2的COLINA目标 356 214 All SZGR 2.0 genes in this pathway
米利假足趋化趋化性 74 45 All SZGR 2.0 genes in this pathway
由MYC DN监管 253 192 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 88 68 All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老 572 352 All SZGR 2.0 genes in this pathway
pILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway
双龙血清敏感基因 90 54 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
Servitja Islet HNF1A靶向 163 111 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
杨BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN 418 245 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway
Altemeier对LPS具有机械通气的反应 128 81 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 534 540 M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-145 319 325 M8 HSA-MIR-145 guccaguuucccaggaaucccuu
miR-23 42 49 1A，M8 HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
mir-323 42 48 1a hsa-miR-323brain gcacauuacggucgaccucu
miR-381 379 385 1a HSA-MIR-381 uauacaagggcaagcucucugu
mir-409-3p 533 539 M8 HSA-MIR-409-3P cgauauguugcucggugaaccccu
miR-485-5p 489 495 1a hsa-miR-485-5p aggcuggccgugaugauuc