Summary
GeneID 9612
Symbol NCOR2
Synonyms CtG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1
Description 核受体Corepressor 2
参考erence MIM:600848|HGNC:HGNC:7673|Ensembl:ENSG00000196498|HPRD:02910|Vega:OTTHUMG00000150455
基因类型 蛋白质编码
Map location 12q24
Pascal p-value 0.008
Sherlock p-value 0.704
胎儿β -0.704
DMG 2 (# studies)
主持人 Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 全基因组DNA甲基化分析 this dataset includes 172 replicated associations between CpGs with schizophrenia. 6
DMG:Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针,对应于精神分裂症患者(n = 24)和对照组(n = 24)之间的2929个独特基因。 6
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM表

Gene 染色体 位置 参考 alt 成绩单 一个一个change Mutation type Sift CG46 特征 学习
NCOR2 chr12 124856705 C t NM_001077261
NM_001206654
NM_006312


silent
silent
silent
Schizophrenia DNM:Fromer_2014
NCOR2 chr12 124821527 G 一个 NM_001077261
NM_001206654
NM_006312
p.1953R>C
p.1953R>C
p.1963R>C
missense
missense
missense
Schizophrenia DNM:Gulsuner_2013

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p(dis) Beta (dis) fdr(dis) 学习
cg26385126 12 124912021 NCOR2 4.99E-7 0.006 0.014 DMG:Montano_2016
cg27431877 12 124911924 NCOR2 2.29E-5 0.005 0.066 DMG:Montano_2016
CG11311053 12 124912049 NCOR2 6.7e-5 0.006 0.105 DMG:Montano_2016
ch.12.2647993F 12 124837365 NCOR2 1.157E-4 -0.649 0.029 DMG:Wockner_2014
cg26385126 12 124912021 NCOR2 2.517E-4 0.489 0.037 DMG:Wockner_2014
CG09942210 12 124965227 NCOR2 3.422E-4 -0.48 0.041 DMG:Wockner_2014

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 eQTL type
rs11057881 chr12 125371972 NCOR2 9612 0.09 顺式
RS13297121 Chr9 71994881 NCOR2 9612 0.1 反式

第二节。转录组注释

一般基因表达(GTEX)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
共有269个时间点秘密策划,n = 38胎儿samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25%和上层25%。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子的乐趣ction 去学期 证据 神经关键字 PubMed ID
GO:0004872 receptor activity IEA -
去:0003677 DNA binding IEA -
GO:0003714 反式cription corepressor activity t一个S 7566127
去:0005112 Notch binding IPI 10713164
去:0005515 蛋白质结合 IPI 10713164|15016912
Biological process 去学期 证据 神经关键字 PubMed ID
GO:0006355 调节转录,DNA依赖性的调节 IEA -
GO:0045449 转录的调节 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去:0005634 nucleus t一个S 10097068
去:0005730 nucleolus IDA 18029348

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ar 一个IS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM 雄激素受体 亲和力捕获 - 韦斯特恩
Co-localization
重构的复合物
two-hybrid
Biogrid 11923464|12441355
|14593076
Bcl6 BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51 B细胞CLL/淋巴瘤6 - HPRD,BioGRID 9765306
Bcl6 BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51 B细胞CLL/淋巴瘤6 Bcl6 BTB结构域中的侧向凹槽基序与SMRT的BBD基序相互作用。 绑定 15531890
BIRC3 一个IP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49 baculoviral IAP repeat-containing 3 CIAP-2启动子与SMRT相互作用。 绑定 15494311
CBFA2T2 DKFZp313F2116 | EHT | MTGR1 | ZMYND3 核心结合因子,runt域,α亚基2;易位到2 - HPRD 12242670
CCL3 G0S19-1 |ld78alpha |MIP-1-Alpha |MIP1A |Scya3 chemokine (C-C motif) ligand 3 SMRT interacts with the CCL3 promoter region. 绑定 15531890
CCND2 Kiak0002 |MGC102758 cyclin D2 SMRT与CCND2启动子区域相互作用。 绑定 15531890
CDKN2A arF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) NCOR2(SMRT)与P-P14(ARF)(P14(ARF)启动子)相互作用。 绑定 15729358
CHUK ikbka |ikk-alpha |ikk1 |ikka |nfkbika |TCF16 conserved helix-loop-helix ubiquitous kinase IKK-alpha phosphorylates SMRT. 绑定 15494311
CIR - CBF1 interacting corepressor - HPRD,BioGRID 11509665
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 ESR1 (ER-alpha) interacts with NCOR2 (SMRT). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and NCOR2 from an unspecified species. 绑定 12738788
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 - HPRD 9702189
fos AP-1 |C-fos v-fos FBJ murine osteosarcoma viral oncogene homolog - HPRD,BioGRID 10777532
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 亲和力捕获 - 韦斯特恩
Co-purification
Biogrid 11013263|11739383
HDAC10 DKFZp761B039 | MGC149722 histone deacetylase 10 - HPRD,BioGRID 11739383
HDAC2 RPD3 |YAF1 histone deacetylase 2 Co-purification Biogrid 11013263
HDAC3 HD3 |RPD3 |RPD3-2 histone deacetylase 3 一个ffinity Capture-MS
亲和力捕获 - 韦斯特恩
Co-fractionation
Co-purification
重构的复合物
Biogrid 10809664|10944117
|11013263|11804585
|12502735|12628926
|14527417
HDAC4 HA6116 |HD4 |HDAC-A |hdaca |KIAA0288 histone deacetylase 4 - HPRD,BioGRID 11804585
HDAC5 FLJ90614 |HD5 |NY-CO-9 histone deacetylase 5 - HPRD 10869435
HDAC5 FLJ90614 |HD5 |NY-CO-9 histone deacetylase 5 重构的复合物
two-hybrid
Biogrid 10640275
HDAC7 DKFZP586J0917 |FLJ99588 |HD7A |HDAC7A histone deacetylase 7 亲和力捕获 - 韦斯特恩 Biogrid 11466315
IKZF1 HS.54452 |IK1 |Ikaros |lyf1 |Pro0758 |Znfn1a1 |Hik-1 Ikaros家庭锌指1(Ikaros) 亲和力捕获 - 韦斯特恩 Biogrid 11959865
IL8 CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1 interleukin 8 IL-8启动子与SMRT相互作用。 绑定 15494311
INPP5K PPS | SKIP inositol polyphosphate-5-phosphatase K two-hybrid Biogrid 11509665
六月 AP-1 |AP1 |C-Jun jun oncogene 重构的复合物
two-hybrid
Biogrid 10777532
MYBL2 B-MYB | BMYB | MGC15600 V-Myb髓细胞增生病毒癌基因同源物(Avian)类似2 - HPRD 11997503
MYOD1 MYF3 | MYOD | PUM | bHLHc1 myogenic differentiation 1 - HPRD 10406466
NCOA3 一个CtR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIP 核受体共激活因子3 - HPRD 9267036
NCOR1 KIAA1047 |MGC104216 |n-cor |trac1 |HCIT529I10 |hn-cor 核受体共抑制剂1 Co-fractionation Biogrid 10944117
NFKB1 DKFZP686C01211 |EBP-1 |kbf1 |MGC54151 |nf-kappa-b |NFKB-P105 |NFKB-P50 |P105 B细胞中Kappa光多肽基因增强子的核因子1 - HPRD 10777532
NFKBIA IKBA | MAD-3 | NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 亲和力捕获 - 韦斯特恩 Biogrid 12589049
NR3C1 GCCR |GCR |gr |grl 核受体亚科3,C组,成员1(糖皮质激素受体) - HPRD,BioGRID 12011091
NR4A1 GFRP1 | HMR | MGC9485 | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3 核受体亚科4,A组,成员1 - HPRD,BioGRID 11559707
PML MYL | PP8675 | RNF71 | TRIM19 promyelocytic leukemia - HPRD,BioGRID 11585900
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 - HPRD,BioGRID 11134019
PPARA MGC2237 | MGC2452 | NR1C1 | PPAR | hPPAR 过氧化物酶体增殖物激活受体α - HPRD,BioGRID 11845213
ppard FAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARB peroxisome proliferator-activated receptor delta - HPRD,BioGRID 11867749
ppard FAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARB peroxisome proliferator-activated receptor delta PPAR-DELTA与SMRT相互作用。这种相互作用是根据未指定来源的PPAR-DELTA和SMRT之间的相互作用进行建模的。 绑定 12970571
拉拉 NR1B1 | RAR retinoic acid receptor, alpha 亲和力捕获 - 韦斯特恩
重构的复合物
Biogrid 9256429|11929748
拉拉 NR1B1 | RAR retinoic acid receptor, alpha NCOR2(SMRT)与P-RAR-ALPHA2(RAR-ALPHA2启动子)相互作用。 绑定 15729358
RBPJ CBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | csl recombination signal binding protein for immunoglobulin kappa J region - HPRD,BioGRID 11509665
RELA MGC131774 |NFKB3 |P65 V-REL网状内皮症病毒性癌基因同源物A(Avian) - HPRD,BioGRID 12589049
runx1t1 一个ML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2 与RUNT相关的转录因子1;易位为1(Cyclin D相关) - HPRD,BioGRID 11113190
SAP30 - SIN3A相关蛋白,30KDA - HPRD 9702189
SAP30 - SIN3A相关蛋白,30KDA Co-purification Biogrid 11013263
sin3a DKFZP434K2235 |FLJ90319 |KIAA0700 SIN3同源物A,转录调节剂(酵母) Co-fractionation
重构的复合物
Biogrid 10640275|10944117
SIRT1 SIR2L1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) SIRT1与SMRT相互作用。 绑定 15175761
SMARCA4 BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Co-fractionation Biogrid 10944117
SNW1 Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIP SNW domain containing 1 亲和力捕获 - 韦斯特恩
体外
in vivo
two-hybrid
Biogrid 10644367|10713164
SNW1 Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIP SNW domain containing 1 - HPRD 10713164|11509665
SPEN KIAA0929 |薄荷|RP1-134O19.1 |锋利的 spen homolog, transcriptional regulator (Drosophila) - HPRD,BioGRID 11331609
SRF MCM1 serum response factor (c-fos serum response element-binding transcription factor) - HPRD,BioGRID 10777532
Stat5一个 MGF | STAT5 signal transducer and activator of transcription 5A - HPRD 11726519
Stat5B Stat5 signal transducer and activator of transcription 5B - HPRD 11726519
tBL1X EBI | SMAP55 | TBL1 跨多霉素(β)类似1倍连接 - HPRD,BioGRID 10809664
tHRB ERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2 thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) 重构的复合物 Biogrid 9751500
VDR NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor 重构的复合物 Biogrid 12460926
YWHAE 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白,epsilon多肽 14-3-3- epsilon与SMRT相互作用。 绑定 15494311
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 - HPRD 9256429|14982881
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 亲和力捕获 - 韦斯特恩
重构的复合物
two-hybrid
Biogrid 9256429|9765306
|14982881
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 SMRT与PLZF相互作用。这种相互作用是基于未指定物种的SMRT和PLZF之间的相互作用进行建模的。 绑定 9486654


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Kegg Notch信号通路 47 35 一个ll SZGR 2.0 genes in this pathway
Biocarta Carm er途径 35 27 一个ll SZGR 2.0 genes in this pathway
Biocarta EGFR Smrte途径 11 11 一个ll SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 一个ll SZGR 2.0 genes in this pathway
BIOCARTA ETS PATHWAY 18 12 一个ll SZGR 2.0 genes in this pathway
BIOCARTA RARRXR PATHWAY 15 9 一个ll SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 59 49 一个ll SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 34 27 一个ll SZGR 2.0 genes in this pathway
PID HDAC Classi途径 66 50 一个ll SZGR 2.0 genes in this pathway
PID RXR VDR PATHWAY 26 24 一个ll SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY 65 37 一个ll SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 30 23 一个ll SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 一个ll SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 一个ll SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 46 28 一个ll SZGR 2.0 genes in this pathway
Notch的Reactome信号传导1 70 46 一个ll SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 38 26 一个ll SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 20 14 一个ll SZGR 2.0 genes in this pathway
Reactome通用转录途径 352 181 一个ll SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 一个ll SZGR 2.0 genes in this pathway
反应组脂肪酸三酰甘油和酮体代谢 168 115 一个ll SZGR 2.0 genes in this pathway
白色脂肪细胞分化的Reactome转录调节 72 53 一个ll SZGR 2.0 genes in this pathway
Notch的Reactome信号传导 103 64 一个ll SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 63 42 一个ll SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 一个ll SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn 493 298 一个ll SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 一个ll SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 95 64 一个ll SZGR 2.0 genes in this pathway
DN SENESE HDAC3目标 536 332 一个ll SZGR 2.0 genes in this pathway
EWSR1 FLII融合DN的Kinsey目标 329 219 一个ll SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 一个ll SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS 18 15 一个ll SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 44 31 一个ll SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 108 74 一个ll SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 一个ll SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 一个ll SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 一个ll SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 一个ll SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 98 59 一个ll SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 一个ll SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植OK vs捐助者 151 100 一个ll SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA UP 51 29 一个ll SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 一个ll SZGR 2.0 genes in this pathway
皮肤上的theilgaard中性粒细胞 77 52 一个ll SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN 50 32 一个ll SZGR 2.0 genes in this pathway
卫星对干扰素βdn的响应 52 33 一个ll SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 一个ll SZGR 2.0 genes in this pathway
Sesto对UV C5的反应 46 36 一个ll SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 一个ll SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 一个ll SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 一个ll SZGR 2.0 genes in this pathway
Hsiao家政基因 389 245 一个ll SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 一个ll SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 一个ll SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 一个ll SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 一个ll SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-10 670 677 1A,M8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b uacccuguagaaccgaauuugu
mir-124.1 169 175 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-125/351 215 221 M8 hsa-miR-125bbrain ucccugagacccuaacuuguga
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-184 136 143 1A,M8 HSA-MIR-184 uggacggaaCugauaagggu
miR-29 232 238 M8 HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ UAGCACCAUUUGAAAUCGGU
mir-30-5p 224 230 M8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-331 217 223 1A hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
mir-9 377 383 M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA