Gene Page:CD63

Summary?
GeneID 967
Symbol CD63
Synonyms LAMP-3|ME491|MLA1|OMA81H|TSPAN30
Description CD63 molecule
Reference MIM:155740|HGNC:HGNC:1692|Ensembl:ENSG00000135404|HPRD:01121|Vega:OTTHUMG00000170454
Gene type protein-coding
Map location 12q13.2
Pascal p-value 0.636
Sherlock p-value 0.288
Fetal beta -0.745
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21601059 12 56122983 CD63 3.09E-4 -0.186 0.04 DMG:Wockner_2014
cg19987288 12 56122958 CD63 4.436E-4 -0.607 0.045 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9313483 chr5 169448229 CD63 967 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HLA-DPA1 0.93 0.94
HLA-DRA 0.88 0.90
HLA-DRB1 0.84 0.88
HLA-DQA1 0.80 0.85
HLA-DRB5 0.79 0.83
HLA-DPB1 0.79 0.86
HLA-DMB 0.78 0.81
EVI2B 0.78 0.85
HLA-DMA 0.77 0.78
MAP7 0.75 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1949 -0.54 -0.66
TUBB2B -0.54 -0.72
NKIRAS2 -0.53 -0.63
ZNF311 -0.52 -0.65
ZNF821 -0.52 -0.63
SH3BP2 -0.52 -0.70
ZNF300 -0.52 -0.64
AC004017.1 -0.52 -0.64
ZNF551 -0.51 -0.64
TIGD1 -0.51 -0.63

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AP4M1 MU-4 | MU-ARP2 adaptor-related protein complex 4, mu 1 subunit - HPRD,BioGRID 10436028
CD81 S5.7 | TAPA1 | TSPAN28 CD81 molecule - HPRD 12036870
CD81 S5.7 | TAPA1 | TSPAN28 CD81 molecule in vivo BioGRID 9006891
CD82 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 CD82 molecule - HPRD,BioGRID 9759843
CD9 5H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29 CD9 molecule - HPRD,BioGRID 8630057|11204565
|12175627
HLA-DMB D6S221E | RING7 major histocompatibility complex, class II, DM beta - HPRD,BioGRID 9759843
HLA-DOB DOB major histocompatibility complex, class II, DO beta Affinity Capture-Western BioGRID 9759843
HLA-DRA HLA-DRA1 major histocompatibility complex, class II, DR alpha - HPRD,BioGRID 9759843
ITGA6 CD49f | DKFZp686J01244 | FLJ18737 | ITGA6B | VLA-6 integrin, alpha 6 - HPRD,BioGRID 7629079
ITGB1 CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Affinity Capture-Western BioGRID 12175627
KIT C-Kit | CD117 | PBT | SCFR v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog - HPRD,BioGRID 12036870
PTGFRN CD315 | CD9P-1 | EWI-F | FLJ11001 | FPRP | KIAA1436 | SMAP-6 prostaglandin F2 receptor negative regulator - HPRD,BioGRID 11278880
SRF MCM1 serum response factor (c-fos serum response element-binding transcription factor) Two-hybrid BioGRID 9271374


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 58 44 All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP 57 41 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP 61 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP 51 30 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP 56 34 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 60 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 62 35 All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN 44 30 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 81 52 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 52 33 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
LEIN ASTROCYTE MARKERS 42 35 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 171 96 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP 36 24 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS NEURAL UP 18 13 All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198 128 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
AGUIRRE胰腺癌COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP 18 11 All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 36 23 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 66 38 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway