Gene Page:FAM53B

年代ummary?
GeneID 9679
年代ymbol FAM53B
年代ynonyms KIAA0140|bA12J10.2|smp
Description family with sequence similarity 53 member B
Reference HGNC:HGNC:28968|Ensembl:ENSG00000189319|HPRD:13314|Vega:OTTHUMG00000019215
Gene type protein-coding
Map location 10q26.13
Pascal p-value 0.192
年代herlock p-value 0.659
DEG p-value DEG:Zhao_2015:p=3.37e-04:q=0.0924
Fetal beta 0.294
eGene Myers' cis & trans
年代upport Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DEG:Zhao_2015 RNA Sequencing analysis Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03487

年代ection I. Genetics and epigenetics annotation

@eQTL annotation

年代NP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1465923 chr4 77136210 FAM53B 9679 0.18 trans
rs7830259 chr8 14087643 FAM53B 9679 0.02 trans

年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
C14orf153 0.88 0.87
FBXL2 0.86 0.84
KCTD2 0.86 0.86
AP2A2 0.85 0.81
LRSAM1 0.85 0.81
GPRASP2 0.85 0.78
TM2D3 0.85 0.80
GARS 0.84 0.78
OPTN 0.84 0.84
PRKRA 0.84 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
AF347015.21 -0.77 -0.64
MT-CO2 -0.77 -0.65
AF347015.8 -0.76 -0.64
AF347015.31 -0.75 -0.63
AF347015.2 -0.73 -0.62
MT-CYB -0.73 -0.61
AF347015.33 -0.72 -0.59
AF347015.27 -0.72 -0.62
AF347015.15 -0.71 -0.61
AF347015.26 -0.69 -0.58

年代ection III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008150 biological_process ND -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
年代MITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP 86 48 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C UP 47 29 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220 133 All SZGR 2.0 genes in this pathway

年代ection VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 3005 3011 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 493 499 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-130/301 3869 3875 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-185 499 505 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-31 3505 3511 1A hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-346 1285 1291 1A hsa-miR-346brain UGUCUGCCCGCAUGCCUGCCUCU
miR-378 3893 3899 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU