Gene Page:ZSCAN12

年代ummary?
GeneID 9753
年代ymbol ZSCAN12
年代ynonyms ZFP96|ZNF29K1|ZNF305|ZNF96|dJ29K1.2
Description zinc finger and SCAN domain containing 12
Reference MIM:603978|HGNC:HGNC:13172|Ensembl:ENSG00000158691|HPRD:15767|
Gene type protein-coding
Map location 6p21
Pascal p-value 1E-12
Fetal beta 1.432
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

年代ection I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) 年代tudy
cg02622316 6 28367410 ZSCAN12 8.68E-8 -0.008 2E-5 DMG:Jaffe_2016


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
MTMR15 0.90 0.87
C1orf58 0.90 0.90
TM9SF3 0.89 0.88
CLCN3 0.88 0.87
COPB2 0.88 0.88
USP38 0.88 0.88
IPO8 0.88 0.88
TRIP12 0.88 0.88
MON2 0.88 0.89
FBXW11 0.88 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
AF347015.21 -0.74 -0.64
MT-CO2 -0.68 -0.63
IFI27 -0.66 -0.61
AF347015.31 -0.66 -0.62
IL32 -0.65 -0.56
AF347015.8 -0.65 -0.61
HIGD1B -0.64 -0.59
FXYD1 -0.63 -0.59
CXCL14 -0.62 -0.61
C1orf54 -0.61 -0.58

年代ection III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006350 transcription IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005634 nucleus IEA -

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
年代CHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L0 L1 UP 17 12 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 97 53 All SZGR 2.0 genes in this pathway
FLOTHO PEDIATRIC ALL THERAPY RESPONSE DN 29 17 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway