Gene Page:RAPGEF5

Summary?
GeneID 9771
Symbol RAPGEF5
Synonyms GFR|MR-GEF|REPAC
Description Rap guanine nucleotide exchange factor 5
Reference MIM:609527|HGNC:HGNC:16862|Ensembl:ENSG00000136237|HPRD:15208|Vega:OTTHUMG00000152525
Gene type protein-coding
Map location 7p15.3
Pascal p-value 0.035
Sherlock p-value 0.694
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description 我nfo
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BTBD9 0.88 0.89
TRAPPC10 0.86 0.86
ABR 0.86 0.87
ATXN1L 0.86 0.86
SYT11 0.86 0.86
RGL1 0.86 0.86
HIPK1 0.85 0.87
RAPGEF2 0.85 0.86
LRP11 0.85 0.84
MTMR12 0.85 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.57 -0.48
C1orf54 -0.55 -0.54
GNG11 -0.54 -0.49
我L32 -0.53 -0.51
SYCP3 -0.53 -0.53
AL050337.1 -0.51 -0.49
C1orf61 -0.50 -0.52
AC098691.2 -0.50 -0.48
APOC1 -0.49 -0.42
VAMP5 -0.49 -0.38

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005085 guanyl-nucleotide交换因素活动 我EA -
GO:0017034 Rap guanyl-nucleotide exchange factor activity 我DA 10486569
GO:0030742 GTP-dependent protein binding 我PI 10934204
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development NAS neurite (GO term level: 5) 10486569
GO:0007264 small GTPase mediated signal transduction 我EA -
GO:0051056 regulation of small GTPase mediated signal transduction 我EA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular 我EA -
GO:0005634 nucleus 我DA 10486569

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway 我nfo
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 84 53 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 74 44 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN 31 19 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201 127 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 68 44 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN 52 35 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
我VANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160 103 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP 46 28 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP 107 59 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 110 66 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 3554 3560 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-125/351 3790 3797 1A,m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-137 3997 4004 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-144 3554 3560 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-182 3527 3534 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-196 3779 3785 1A hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-218 1871 1877 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-219 621 627 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-378 149 155 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-496 3983 3989 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-96 3528 3534 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC