Gene Page:DAZAP2

Summary？
基因 9802
象征 DAZAP2
Synonyms PRTB
Description 戴兹相关蛋白2
Reference MIM：607431|HGNC:HGNC:2684|ENSEMBL：ENSG00000183283|HPRD:08463|Vega：Otthumg00000169649
基因类型 蛋白质编码
Map location 12Q12
Pascal p-value 0.093
Sherlock p-value 0.614
胎儿β -0.791
DMG 1(# studies)

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.01

Section I. Genetics and epigenetics annotation

@差异甲基化基因

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
cg17322163 12 51632344 DAZAP2 1.476E-4 -0.324 0.032 DMG：Wockner_2014


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23岁）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
CCNH 0.82 0.81
ATP5C1 0.81 0.81
PSMA6 0.81 0.80
C3orf14 0.81 0.84
NFU1 0.80 0.81
CHMP5 0.80 0.81
MRPL1 0.79 0.81
PSMC6 0.79 0.83
TXNDC9 0.79 0.82
PARL 0.79 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
DOCK6 -0.58 -0.63
工程 -0.56 -0.58
NOS3 -0.52 -0.56
FAM38A -0.51 -0.57
lims2 -0.51 -0.56
GATA2 -0.50 -0.54
MTSS1L -0.50 -0.51
sema3g -0.49 -0.52
AF347015.18 -0.48 -0.46
LAMB2 -0.48 -0.53

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 16713569

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
AATF CHE-1 | CHE1 | DED apoptosis antagonizing transcription factor Two-hybrid Biogrid 16189514
Bag3 BAG-3 | BIS | CAIR-1 | MGC104307 BCL2-associated athanogene 3 Two-hybrid Biogrid 16189514
BATF2 MGC20410 基本亮氨酸拉链转录因子，类似于ATF的2 Two-hybrid Biogrid 16189514
C1orf94 MGC15882 染色体1开放阅读框94 Two-hybrid Biogrid 16189514
Calcoco2 MGC17318 |NDP52 calcium binding and coiled-coil domain 2 Two-hybrid Biogrid 16189514
CCDC120 JM11 coiled-coil domain containing 120 Two-hybrid Biogrid 16189514
DAZ1 DAZ | SPGY 在Azoospermia 1中删除1 - HPRD,BioGRID 10857750
DAZAP2 KIAA0058 | MGC14319 | MGC766 | PRTB 戴兹相关蛋白2 Two-hybrid Biogrid 16189514
达兹 达兹|dazl1 |达兹拉|MGC26406 |Spgyla deleted in azoospermia-like - HPRD,BioGRID 10857750
dcun1d1 DCUN1L1 | RP42 | SCCRO | SCRO | Tes3 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) Two-hybrid Biogrid 16189514
FAM46C FLJ20202 family with sequence similarity 46, member C Two-hybrid Biogrid 16189514
FLJ20433 FLJ30442 |MGC131904 |MGC74981 假设蛋白FLJ20433 Two-hybrid Biogrid 16189514
GPSM1 AGS3 | DKFZp727I051 G蛋白信号调节剂1（类似AGS3，秀丽隐杆线虫） Two-hybrid Biogrid 16189514
HGS HRS |ZFYVE8 肝细胞生长因子-regulated tyrosine kinase substrate Two-hybrid Biogrid 16189514
LMO2 rbtn2 |rbtnl1 |Rhom2 |TTG2 LIM domain only 2 (rhombotin-like 1) Two-hybrid Biogrid 16189514
LOC83459 MGC88636 假设蛋白LOC83459 Two-hybrid Biogrid 16189514
NDUFA5 B13 |CI-13KD-B |DKFZP781K1356 |FLJ12147 |nufm |UQOR13 NADH脱氢酶（泛氨基酮）1α子复合物，5，13KDA Two-hybrid Biogrid 16189514
NEDD4 KIAA0093 | MGC176705 | NEDD4-1 | RPF1 神经前体细胞表达，发育下调4 - HPRD 11342538
NOC4L MGC3162 |NOC4 核仁复合物相关4同源物（酿酒酵母） Two-hybrid Biogrid 16189514
PLSCR1 mmtra1b phospholipid scramblase 1 Two-hybrid Biogrid 16189514
POLI rad30b |rad3ob 聚合酶（定向DNA）IOTA Two-hybrid Biogrid 16189514
RBM9 FOX2 | Fox-2 | HNRBP2 | HRNBP2 | RTA | dJ106I20.3 | fxh RNA结合基序蛋白9 Two-hybrid Biogrid 16189514
rbpms 爱马仕 RNA binding protein with multiple splicing Two-hybrid Biogrid 16189514
RHOXF2 PEPP-2 |pepp2 |THG1 Rhox Homeobox家族，会员2 Two-hybrid Biogrid 16189514
RPS27A CEP80 |Hubcep80 |UBA80 |ubcep1 |UBCEP80 核糖体蛋白S27a Two-hybrid Biogrid 16189514
SEPT2 diff6 |KIAA0158 |nedd5 |pnutl3 |hnedd5 9月2日 Two-hybrid Biogrid 16189514
STAM2 DKFZP564C047 |HBP |stam2a |Stam2b signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 Two-hybrid Biogrid 16189514
Tollip FLJ33531 |IL-1RACPIP Toll相互作用蛋白质 Two-hybrid Biogrid 16189514
UBAC1 gbdr1 |RP11-432J22.3 |UBADC1 包含1的UBA域 Two-hybrid Biogrid 16189514
UBB FLJ25987 | MGC8385 泛素b Two-hybrid Biogrid 16189514
UBC HMG20 泛素c Two-hybrid Biogrid 16189514
WWP1 AIP5 |DKFZP434D2111 |tiul1 |HSDRP1 含有E3泛素蛋白连接酶1的WW结构域1 Two-hybrid Biogrid 16189514
ZFAND2B - zinc finger, AN1-type domain 2B Two-hybrid Biogrid 16189514
ZNF581 FLJ22550 |HSPC189 锌指蛋白581 Two-hybrid Biogrid 16189514


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Liu Sox4靶向DN 309 191 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
Provenzani转移 194 112 All SZGR 2.0 genes in this pathway
Amundson对砷的回应 217 143 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN 584 395 All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
洛佩兹MBD目标 957 597 All SZGR 2.0 genes in this pathway
Shen Smarca2目标 424 268 All SZGR 2.0 genes in this pathway
宁慢性阻塞性肺疾病DN 121 79 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK 169 111 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 98 67 All SZGR 2.0 genes in this pathway
Sesto对UV C0的反应 107 72 All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN 106 68 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
Ellwood Myc Targets DN 40 27 All SZGR 2.0 genes in this pathway
Hsiao家政基因 389 245 All SZGR 2.0 genes in this pathway
Kim所有疾病少突胶质细胞编号corr up 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS 90 56 All SZGR 2.0 genes in this pathway
Linsley mir16目标 206 127 All SZGR 2.0 genes in this pathway
Lee BMP2目标 745 475 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-125/351 1075 1081 1a hsa-miR-125bbrain ucccugagacccuaacuuguga
hsa-miR-125abrain ucccugagacccuuaaccugug
miR-128 1233 1239 M8 hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
mir-132/212 1195 1202 1A，M8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-17-5p/20/93.mr/106/519.d 143 149 M8 HSA-MIR-17-5P caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ caaagugcuugugcagguag
HSA-MIR-519D caaagugccucccuuuagugugu
miR-181 231 237 M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ aacauucauugcugucggggg
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain aacauucauuguugucggggguggguu
miR-182 367 374 1A，M8 HSA-MIR-182 uuuggcaaugguagaacucaca
mir-452 808 814 M8 hsa-miR-452 UGUUUGCAGAGGAAACUGAGAC
miR-496 168 174 M8 HSA-MIR-496 Auuacauggccaaucuc
miR-93.hd/291-3p/294/295/302/372/373/520 1242 1248 1a HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d Uaagugcuauguugugugu
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu
HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d Uaagugcuauguugugugu
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu
mir-96 368 374 1a HSA-MIR-96brain uuuggcacuagcacauuuuugc