Gene Page:Zeb2

Summary？
基因 9839
象征 Zeb2
Synonyms HSPC082 | SIP-1 | SIP1 | SMADIP1 | ZFHX1B
Description 锌指EBOXBINDING HONEOBOX 2
Reference MIM：605802|HGNC：HGNC：14881|Ensembl:ENSG00000169554|HPRD：05780|Vega:OTTHUMG00000187624
基因类型 蛋白质编码
Map location 2q22.3
Pascal p-value 9.085E-6
Sherlock p-value 0.001
胎儿β 1.611
DMG 1(# studies)
主持人 Myers' cis & trans
Support CompositeSet
Darnell FMRP目标

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历：Gwascat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
CV:Ripke_2013 Genome-wide Association Study Multi-stage GWAS, Sweden population and PGC2. 24 leading SNPs
DMG：JAFFE_2016 全基因组DNA甲基化分析 This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
LK:YES Genome-wide Association Study This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.02395
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关关键字的命中：2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
cg21701531 2 145275199 Zeb2 7.81e-11 -0.021 4.34e-7 DMG：JAFFE_2016

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
rs6632306 Chrx 35590460 Zeb2 9839 0.06 反式
RS1935404 Chrx 35605181 Zeb2 9839 0.13 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0003676 nucleic acid binding IEA -
GO:0003700 反式cription factor activity IEA -
GO:0008270 锌离子结合 IEA -
GO:0019208 phosphatase regulator activity nas 11477103
GO:0046872 metal ion binding IEA -
GO:0043565 sequence-specific DNA binding IEA -
GO:0046332 Smad结合 nas -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007417 central nervous system development IEA 大脑（GO期限：6） -
GO:0007399 nervous system development nas 神经突（GO期限：5） 11279515
GO:0001756 somitogenesis IEA -
GO:0001755 神经rest细胞迁移 IEA -
GO:0001843 neural tube closure IEA -
去：0006355 调节转录，DNA依赖性的调节 IEA -
GO：0016481 转录的负调节 我知道了 11592033
GO：0048598 embryonic morphogenesis IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005622 细胞内 IEA -
去：0005634 nucleus 我知道了 9853615

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性 351 230 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN 463 290 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
Horiuchi WTAP靶向 306 188 All SZGR 2.0 genes in this pathway
Gargalovic对氧化磷脂黑色DN的反应 11 5 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN 805 505 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应 770 415 All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 TTD DN 84 63 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 54 37 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
通过ERCC3滑落紫外线反应DN 855 609 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM4 261 153 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发6小时DN 514 330 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
Benporath Oct4目标 290 172 All SZGR 2.0 genes in this pathway
Benporath SOX2目标 734 436 All SZGR 2.0 genes in this pathway
Benporath NOS目标 179 105 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
Petretto心脏质量QTL顺式DN 24 15 All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇3 28 23 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏1 182 119 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
伊万诺娃造血晚期祖先 544 307 All SZGR 2.0 genes in this pathway
Nielsen Gist和滑膜肉瘤DN 20 15 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
大脑衰老 262 186 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应 1011 592 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
Labbe TGFB1靶向 102 64 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
罗斯白血病与MLL融合 78 49 All SZGR 2.0 genes in this pathway
Mikkelsen去分化状态DN 7 7 All SZGR 2.0 genes in this pathway
米利假足趋化趋化性 74 45 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 105 75 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K4ME3 AND H3K27ME3 34 21 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K27ME3 42 27 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
Bruins通过TP53组A的UVC响应 898 516 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES 462 273 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-101 1017 1023 1A hsa-miR-101 uacaguacugauaacugaag
miR-129-5p 925 931 1A HSA-MIR-129brain cuuuuugcgguggggcuugc
HSA-MIR-129-5p cuuuuugcgguggggcuugcu
mir-130/301 300 306 M8 hsa-miR-130abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
mir-132/212 1303 1310 1A，M8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-138 766 772 M8 HSA-MIR-138brain AGCUGGUGUUGUGAAUC
miR-139 1018 1024 M8 HSA-MIR-139brain ucuacagugcacgugucu
miR-140 525 531 1A HSA-MIR-140brain AGUGGUUUUACCCUAUGGUAG
miR-141/200a 775 782 1A，M8 HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-142-3p 442 448 1A hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
miR-144 1016 1023 1A，M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-153 689 695 1A HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
HSA-MIR-153 UUGCAUAGUCACAAAAGUGA
miR-19 762 768 M8 HSA-MIR-19A UGUGCAAAUCUAUGCAAAACUGA
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-192/215 956 963 1A，M8 HSA-MIR-192 cugaccuaugaauugacagcc
hsa-miR-215 Augaccuaugaauugacagac
miR-200bc/429 392 398 M8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
mir-205 564 570 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
mir-208 608 614 1A hsa-miR-208 auaagacgaaaaaagcuugu
mir-218 275 282 1A，M8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
mir-221/222 1421 1427 M8 hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
mir-25/32/92/363/367 858 864 M8 hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
miR-26 571 577 1A HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 561 567 1A HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
mir-30-3p 1257 1264 1A，M8 HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P cuuucagucggauguauacagc
mir-30-5p 844 850 1A HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-323 431 437 M8 hsa-miR-323brain gcacauuacggucgaccucu
mir-342 1146 1152 1A hsa-miR-342brain ucucacacagaaaucgcacccccguc
mir-369-3p 1364 1370 M8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 1032 1038 M8 HSA-MIR-374 uuauaauacaAccugauaagug
miR-377 586 593 1A，M8 HSA-MIR-377 aucacacaaaggaacuuuuugu
mir-409-5p 523 529 1A HSA-MIR-409-5P AGGUUACCCGAGCAACUUUGCA
mir-448 688 695 1A，M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
mir-452 691 697 M8 hsa-miR-452 UGUUUGCAGAGGAAACUGAGAC
miR-485-3p 1318 1324 M8 hsa-miR-485-3p gucauacgggcucucucucucucu
miR-499 607 614 1A，M8 HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA