Gene Page:KIAA0319
Summary?
| GeneID | 9856 |
| Symbol | KIAA0319 |
| Synonyms | DYLX2|DYX2|NMIG |
| Description | KIAA0319 |
| Reference | MIM:609269|HGNC:HGNC:21580|Ensembl:ENSG00000137261|HPRD:18713|Vega:OTTHUMG00000014358 |
| Gene type | protein-coding |
| Map location | 6p22.3 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.212 |
| Fetal beta | -0.002 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| Literature | High-throughput literature-search | 与Schizop Co-occurancehrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg12659381 | 6 | 24646254 | KIAA0319 | 4.55E-9 | -0.019 | 2.67E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LCORL | 0.91 | 0.89 |
| ZNF33B | 0.90 | 0.92 |
| COMMD2 | 0.90 | 0.87 |
| CSGALNACT2 | 0.89 | 0.92 |
| DDX21 | 0.89 | 0.92 |
| STT3B | 0.88 | 0.92 |
| EIF4B | 0.88 | 0.88 |
| ZNF33A | 0.88 | 0.93 |
| UBXN2B | 0.88 | 0.94 |
| C14orf37 | 0.87 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERPINB6 | -0.66 | -0.76 |
| HSD17B14 | -0.64 | -0.81 |
| HEPN1 | -0.62 | -0.74 |
| TSC22D4 | -0.62 | -0.78 |
| FXYD1 | -0.62 | -0.85 |
| AIFM3 | -0.62 | -0.75 |
| RAMP1 | -0.61 | -0.78 |
| AC018755.7 | -0.61 | -0.70 |
| AF347015.31 | -0.61 | -0.83 |
| ROM1 | -0.60 | -0.78 |
Section III. Gene Ontology annotation
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| CONCANNON APOPTOSIS BY EPOXOMICIN UP | 239 | 157 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| GARCIA TARGETS OF FLI1 AND DAX1 DN | 176 | 104 | All SZGR 2.0 genes in this pathway |
| LIN NPAS4 TARGETS UP | 163 | 100 | All SZGR 2.0 genes in this pathway |