Gene Page:PSMD6

Summary？
基因 9861
象征 PSMD6
Synonyms Rpn7|S10|SGA-113M|p42A|p44S10
Description 蛋白酶体26S亚基，非ATPase 6
Reference HGNC：HGNC：9564|ENSEMBL：ENSG00000163636|HPRD:18370|Vega：Otthumg00000158765
基因类型 蛋白质编码
Map location 3P14.1
Pascal p-value 2.443e-5
Sherlock p-value 0.377

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0232

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
OAZ1 0.94 0.90
FDX1L 0.90 0.92
TPI1 0.89 0.92
乌罗德 0.89 0.88
tusc2 0.88 0.87
KLHDC3 0.88 0.88
Cox4i1 0.87 0.82
pard6a 0.87 0.88
TMEM205 0.86 0.85
MECR 0.86 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
EIF5B -0.59 -0.72
thoc2 -0.55 -0.57
ZNF326 -0.54 -0.54
SFRS12 -0.52 -0.52
MAP4K4 -0.52 -0.52
RBM25 -0.51 -0.53
UPF3B -0.50 -0.56
AC005035.1 -0.49 -0.50
ZC3H13 -0.47 -0.40
AC005921.3 -0.47 -0.75

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 17353931
GO：0016887 ATPase activity nas 10723133
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006510 ATP依赖性蛋白水解 nas 10723133
GO:0031145 后期促进复合依赖性蛋白酶体依赖性蛋白质分解代谢过程 经验 11285280
GO：0051436 在有丝分裂细胞周期期间泛素 - 蛋白连接酶活性的负调控 经验 15029244
GO：0051437 positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle 经验 12791267
Cellular component 去学期 证据 神经关键字 PubMed ID
GO：0000502 proteasome complex nas 10723133
GO:0005829 细胞质 IEA -
GO：0043234 protein complex IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
PAAF1 FLJ11848 |PAAF |RPN14 |WDR71 蛋白酶体ATPase相关因子1 Affinity Capture-MS Biogrid 17353931
PSMA2 HC3 |Mu |PMSA2 |PSC2 proteasome (prosome, macropain) subunit, alpha type, 2 Affinity Capture-MS Biogrid 17353931
PSMB5 LMPX |MB1 |MGC104214 |X 蛋白酶体（Prosome，宏观）亚基，β类型，5 Affinity Capture-MS Biogrid 17353931
PSMC1 MGC24583 |MGC8541 |P26S4 |S4 |p56 proteasome (prosome, macropain) 26S subunit, ATPase, 1 Affinity Capture-MS Biogrid 17353931
PSMC2 MGC3004 | MSS1 | Nbla10058 | S7 proteasome (prosome, macropain) 26S subunit, ATPase, 2 Affinity Capture-MS Biogrid 17353931
PSMC3 MGC8487 |TBP1 proteasome (prosome, macropain) 26S subunit, ATPase, 3 Affinity Capture-MS Biogrid 17353931
PSMC4 MGC13687 |MGC23214 |MGC8570 |MIP224 |S6 |TBP7 proteasome (prosome, macropain) 26S subunit, ATPase, 4 Affinity Capture-MS Biogrid 17353931
PSMC5 S8 |sug1 |TBP10 |Trip1 |P45 |p45/sug proteasome (prosome, macropain) 26S subunit, ATPase, 5 Affinity Capture-MS Biogrid 17353931
PSMC6 CADP44 | MGC12520 | P44 | SUG2 | p42 proteasome (prosome, macropain) 26S subunit, ATPase, 6 Affinity Capture-MS Biogrid 17353931
PSMD1 MGC133040 | MGC133041 | P112 | Rpn2 | S1 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，1 Affinity Capture-MS Biogrid 17353931
PSMD10 dJ889N15.2 | p28 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，10 Affinity Capture-MS Biogrid 17353931
PSMD11 MGC3844 | Rpn6 | S9 | p44.5 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，11 Affinity Capture-MS Biogrid 17353931
PSMD12 MGC75406 |rpn5 |p55 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，12 Affinity Capture-MS Biogrid 17353931
PSMD13 HSPC027 |rpn9 |S11 |P40.5 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，13 Affinity Capture-MS Biogrid 17353931
PSMD14 pad1 |poh1 |RPN11 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，14 Affinity Capture-MS Biogrid 17353931
PSMD2 MGC14274 | P97 | Rpn1 | S2 | TRAP2 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，2 Affinity Capture-MS Biogrid 17353931
PSMD3 P58 |rpn3 |S3 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，3 Affinity Capture-MS Biogrid 17353931
PSMD4 AF |AF-1 |ASF |MCB1 |RPN10 |S5A |PUB-R5 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，4 Affinity Capture-MS Biogrid 17353931
PSMD7 mov34 |P40 |rpn8 |S12 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，7 Affinity Capture-MS Biogrid 17353931
PSMD8 HIP6 | HYPF | MGC1660 | Nin1p | Rpn12 | S14 | p31 蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，8 Affinity Capture-MS Biogrid 17353931
Telo2 CLK2 | DKFZp434A073 | FLJ10924 | KIAA0683 | TEL2 | c305C8.3 | hCLK2 TEL2, telomere maintenance 2, homolog (S. cerevisiae) Affinity Capture-MS Biogrid 17353931
UBE3C KIAA0010 |KIAA10 泛素蛋白连接酶E3C 亲和力捕获 - 韦斯特恩 Biogrid 12692129


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg蛋白酶体 48 28 All SZGR 2.0 genes in this pathway
BIOCARTA PROTEASOME PATHWAY 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 65 41 All SZGR 2.0 genes in this pathway
可溶性外源抗原内体的反应组交叉表现 48 29 All SZGR 2.0 genes in this pathway
Reactome抗原加工交叉呈现 76 48 All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 61 40 All SZGR 2.0 genes in this pathway
反应组细胞周期 421 253 All SZGR 2.0 genes in this pathway
Reactome ORC1从染色质中去除 67 37 All SZGR 2.0 genes in this pathway
B细胞受体BCR的Reactome下游信号传导事件 97 66 All SZGR 2.0 genes in this pathway
B细胞中NF Kappab的反应组激活 64 43 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 51 31 All SZGR 2.0 genes in this pathway
反应组CDK介导的磷酸化和CDC6的去除 48 27 All SZGR 2.0 genes in this pathway
氨基酸和衍生物的反应组代谢 200 136 All SZGR 2.0 genes in this pathway
鸟氨酸脱羧酶ODC的反应组调节 49 33 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS 58 34 All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC 325 185 All SZGR 2.0 genes in this pathway
Reactome细胞周期检查点 124 70 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 65 40 All SZGR 2.0 genes in this pathway
Reactome P53依赖G1 DNA损伤响应 57 35 All SZGR 2.0 genes in this pathway
Reactome M G1过渡 81 45 All SZGR 2.0 genes in this pathway
Reactome G1 S过渡 112 63 All SZGR 2.0 genes in this pathway
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 56 31 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 51 30 All SZGR 2.0 genes in this pathway
mRNA的反应组代谢 284 128 All SZGR 2.0 genes in this pathway
READEM RNA的代谢 330 155 All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相 137 79 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 85 46 All SZGR 2.0 genes in this pathway
Reactome有丝分裂M M G1相 172 98 All SZGR 2.0 genes in this pathway
复制前复合物的反应组装 65 36 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 50 All SZGR 2.0 genes in this pathway
AUF1 HNRNP D0对mRNA的反应组不稳定 53 31 All SZGR 2.0 genes in this pathway
Reactome DNA复制 192 110 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
Reactome HIV感染 207 122 All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
Reactome APC C CDH1介导的CDC20和其他APC C CDH1靶向蛋白质的降解早期G1早期 72 38 All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 73 40 All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 64 34 All SZGR 2.0 genes in this pathway
Reactome SCF Beta TRCP介导的EMI1降解 51 32 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
Reactome I类MHC介导的抗原加工表现 251 156 All SZGR 2.0 genes in this pathway
Reactome抗原加工泛素化蛋白酶体降解 212 129 All SZGR 2.0 genes in this pathway
Reactome s阶段 109 66 All SZGR 2.0 genes in this pathway
Reactome SCFSKP2介导的P27 P21降解 56 34 All SZGR 2.0 genes in this pathway
Reactome VIF介导的apobec3g降解 52 30 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 68 44 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK 63 48 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
PAL PRMT5靶向 203 135 All SZGR 2.0 genes in this pathway
Zhu CMV全部 120 89 All SZGR 2.0 genes in this pathway
Sesto对UV C0的反应 107 72 All SZGR 2.0 genes in this pathway
Zhu CMV 24小时 93 65 All SZGR 2.0 genes in this pathway
江缺氧正常 311 205 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 64 40 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
米利假足 518 299 All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应14 143 86 All SZGR 2.0 genes in this pathway
lu eszh2靶向DN 414 237 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN 882 538 All SZGR 2.0 genes in this pathway