SZGR2 - Beplay体育中心

Summary?

基因	9869
Symbol	setDB1
同义词	ESET\|H3-K9-HMTase4\|KG1T\|KMT1E\|TDRD21
描述	设置域分叉1
参考	MIM：604396\|HGNC：HGNC：10761\|Ensembl：ENSG00000143379\|HPRD:06828\|Vega：Otthumg00000035003
基因type	protein-coding
地图位置	1q21
Sherlock P值	0.382
Fetal beta	1.716
eGene	迈尔斯的顺式和跨性别
支持	Ascano FMRP目标染色质重塑基因

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
PMID:cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	基因组扫描荟萃分析	Psr: 0.0235
GSMA_IIA	基因组扫描荟萃分析（所有样品）	Psr: 0.00814
文学	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
网络	最短路径说tance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.125

Section I. Genetics and epigenetics annotation

EQTL注释

SNP ID	Chromosome	Position	eGene	基因Entrez ID	PVALUE	qvalue	TSS distance	eQTL type
RS16955618	CHR15	29937543	setDB1	9869		0.2		trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
WDR6	0.96	0.96
DCAF15	0.96	0.94
MTA1	0.95	0.95
VPS16A	0.94	0.93
axin1	0.94	0.94
RBM15B	0.94	0.93
PABPC4	0.94	0.91
EHMT2	0.94	0.94
CNTROB	0.93	0.96
CHFR	0.93	0.95

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
AF347015.31	-0.78	-0.87
AF347015.27	-0.78	-0.88
MT-CO2	-0.76	-0.87
C5orf53	-0.75	-0.77
AF347015.33	-0.75	-0.85
MT-CYB	-0.74	-0.84
AF347015.8	-0.73	-0.85
S100B	-0.72	-0.79
HLA-F	-0.72	-0.73
COPZ2	-0.71	-0.77

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003677	DNA结合	IEA		-
GO:0005515	protein binding	IPI		11791185\|16682412\|17577629
GO:0016740	transferase activity	IEA		-
去：0008270	锌离子结合	IEA		-
去：0008168	methyltransferase activity	IEA		-
GO：0018024	histone-lysine N-methyltransferase activity	IEA		-
生物过程	GO term	Evidence	Neuro keywords	PubMed ID
去：0006355	regulation of transcription, DNA-dependent	IEA		-
去：0006350	transcription	IEA		-
GO:0016568	染色质修饰	IEA		-
细胞分量	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	核	IEA		-
GO:0005694	chromosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIFM1	AIF \| MGC111425 \| PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	Two-hybrid	BioGRID	16169070
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	胺氧化酶（含黄素）结构域2	Two-hybrid	BioGRID	16169070
ASAH1	AC \| ASAH \| FLJ21558 \| FLJ22079 \| PHP \| PHP32	N-酰基肾上腺素氨基水解酶（酸性神经酶）1	Two-hybrid	BioGRID	16169070
ATF7IP	FLJ10139 \|FLJ10688 \|MCAF \|P621	activating transcription factor 7 interacting protein	-	HPRD	14536086
ATF7IP	FLJ10139 \|FLJ10688 \|MCAF \|P621	activating transcription factor 7 interacting protein	MCAF1 interacts with SETDB1.	BIND	15691849
ATF7IP2	FLJ12668 \|MCAF2	activating transcription factor 7 interacting protein 2	MCAF2interacts with SETDB1.	BIND	15691849
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B相关的成绩单3	Two-hybrid	BioGRID	16169070
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	基本的螺旋 - 环螺旋域，包含B类，2	Two-hybrid	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
BXDC2	BRIX \| FLJ11100	包含2的brix域	Two-hybrid	BioGRID	16169070
C11orf1	FLJ23499	染色体11开放阅读框1	Two-hybrid	BioGRID	16169070
CBX8	HPC3 \|PC3 \|RC1	Chromobox同源物8（PC类同源物，果蝇）	Two-hybrid	BioGRID	16169070
CCDC106	HSU79303 \|ZNF581	coiled-coil domain containing 106	Two-hybrid	BioGRID	16169070
CDK4	CMM3 \| MGC14458 \| PSK-J3	细胞周期蛋白依赖性激酶4	Two-hybrid	BioGRID	16169070
CHAF1A	CAF-1 \|CAF1 \|CAF1B \|CAF1P150 \|MGC71229 \|P150	染色质组装因子1，亚基A（P150）	setDB1interacts with CAF-1.	BIND	15327775
CLSTN1	alc-alpha \|CSTN1 \|FLJ32258 \|KIAA0911 \|pik3cd \|XB31Alpha \|alcalpha1 \|alcalpha2	Calsyntenin 1	-	HPRD	12421765
Creld1	AVSD2 \|Cirrin \|DKFZP566D213	具有EGF样域1的半胱氨酸富含半胱氨酸	Two-hybrid	BioGRID	16169070
DAP	MGC99796	death-associated protein	Two-hybrid	BioGRID	16169070
DLEU1	BCMS \|DLB1 \|dleu2 \|leu1 \|Leu2 \|MGC22430 \|NCRNA00021 \|XTP6	在淋巴细胞性白血病1（非蛋白质编码）中删除	Two-hybrid	BioGRID	16169070
ECSIT	sitpec	ECSIT homolog (Drosophila)	Two-hybrid	BioGRID	16169070
ERH	DROER \| FLJ27340	基本同源物（果蝇）的增强子	Two-hybrid	BioGRID	16169070
Flywch1	-	Flywch型锌指1	Two-hybrid	BioGRID	16169070
GIPC2	FLJ20075 \|SEMCAP-2 \|SEMCAP2	GIPC PDZ域，包含家族，成员2	Two-hybrid	BioGRID	16169070
GPS2	AMF-1 \| MGC104294 \| MGC119287 \| MGC119288 \| MGC119289	G蛋白途径抑制器2	Two-hybrid	BioGRID	16169070
GSTO1	DKFZp686H13163 \| GSTTLp28 \| P28	谷胱甘肽S-转移酶欧米茄1	Two-hybrid	BioGRID	16169070
HDAC1	DKFZP686H12203 \|gon-10 \|HD1 \|RPD3 \|RPD3L1	组蛋白脱乙酰基酶1	-	HPRD	12398767
HDAC2	RPD3 \|YAF1	组蛋白脱乙酰基酶2	Affinity Capture-Western	BioGRID	12398767
Hist2H3A	H3/N \|H3/o	组蛋白簇2，H3A	Reconstituted Complex	BioGRID	11959841
Hist4H4	H4/P \|MGC24116	histone cluster 4, H4	Reconstituted Complex	BioGRID	11959841
HMOX2	HO-2	heme oxygenase (decycling) 2	Two-hybrid	BioGRID	16169070
HSPB3	HSPL27	热冲击27KDA蛋白3	Two-hybrid	BioGRID	16169070
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1结合蛋白	Two-hybrid	BioGRID	16169070
MBD1	CXXC3 \| PCM1 \| RFT	methyl-CpG binding domain protein 1	MBD1 interacts with SETDB1.	BIND	15327775
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1，MPS一个粘合激酶激活剂样3（酵母）	Two-hybrid	BioGRID	16169070
MRPL44	FLJ12701 \|FLJ13990 \|FLJ37688 \|L44MT \|MRP-L44	mitochondrial ribosomal protein L44	Two-hybrid	BioGRID	16169070
NIPSNAP3A	DKFZP564D177 \|FLJ13953 \|HSPC299 \|MGC14553 \|nipsnap4 \|tassc	NIPSNAP同源物3A（秀丽隐杆线虫）	Two-hybrid	BioGRID	16169070
OLFML3	hnoel-iso \|OLF44	嗅蛋白样3	Two-hybrid	BioGRID	16169070
ORAI2	C7orf19 \|CBCIP2 \|FLJ12474 \|FLJ14733 \|FLJ44818 \|TMEM142B	Orai钙释放激活的钙调节剂2	Two-hybrid	BioGRID	16169070
PAFAH1B3	-	血小板激活因子乙酰水合酶，同工型IB，伽马亚基29KDA	Two-hybrid	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	原钙粘蛋白α4	Two-hybrid	BioGRID	16169070
PGAM5	BXLBV68 \|MGC5352	磷酸甘油酸突变酶家族成员5	Two-hybrid	BioGRID	16169070
PHF10	FLJ10975 \| MGC111009 \| XAP135	PhD手指蛋白10	Two-hybrid	BioGRID	16169070
Plekha4	PEPP1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	Two-hybrid	BioGRID	16169070
pola2	FLJ21662 \|FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
PPA1	IOPPP \| MGC111556 \| PP \| PP1 \| SID6-8061	pyrophosphatase (inorganic) 1	Two-hybrid	BioGRID	16169070
PPP1R8	ard-1 \|ard1 \|nipp-1 \|nipp1 \|Pro2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	Two-hybrid	BioGRID	16169070
Prkra	dyt16 \|HSD14 \|协定\|rax	protein kinase, interferon-inducible double stranded RNA dependent activator	Two-hybrid	BioGRID	16169070
PSMD11	MGC3844 \|rpn6 \|S9 \|P44.5	蛋白酶体（Prosome，大蛋白）26S亚基，非ATPase，11	Two-hybrid	BioGRID	16169070
PTPR	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
QTRT1	fp3235 \|TGT	queuine tRNA-ribosyltransferase 1	Two-hybrid	BioGRID	16169070
RNF10	KIAA0262 \| MGC126758 \| MGC126764 \| RIE2	ring finger protein 10	Two-hybrid	BioGRID	16169070
S100A10	42c \|Anx2l \|Anx2lg \|cal1l \|Clp11 \|CA [1] \|GP11 \|MGC111133 \|P11 \|P10	S100 calcium binding protein A10	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	精子/精子N1-乙酰转移酶1	Two-hybrid	BioGRID	16169070
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	-	HPRD，Biogrid	12398767
SIN3B	KIAA0700	SIN3 homolog B, transcription regulator (yeast)	-	HPRD，Biogrid	12398767
SLC38A3	G17 \|nat1 \|SN1	solute carrier family 38, member 3	Two-hybrid	BioGRID	16169070
SULT1E1	EST \| EST-1 \| MGC34459 \| STE	sulfotransferase family 1E, estrogen-preferring, member 1	Two-hybrid	BioGRID	16169070
Suz12	chet9 \|jjaz1 \|KIAA0160	Zeste 12同源物（果蝇）的抑制剂	共纯化	BioGRID	14536086
tardbp	ALS10 \| TDP-43	TAR DNA binding protein	Two-hybrid	BioGRID	16169070
tcerg1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD	15383276
thap8	FLJ32891	包含8个域	Two-hybrid	BioGRID	16169070
TK1	TK2	胸苷激酶1，可溶性	Two-hybrid	BioGRID	16169070
TOB1	APRO6 \| MGC104792 \| MGC34446 \| PIG49 \| TOB \| TROB \| TROB1	ERBB2的传感器，1	Two-hybrid	BioGRID	16169070
TOLLIP	FLJ33531 \| IL-1RAcPIP	Toll相互作用蛋白质	Two-hybrid	BioGRID	16169070
TPI1	MGC88108 \| TPI	三尿磷酸异构酶1	Two-hybrid	BioGRID	16169070
TRBV2	TCRBV22S1A2N1T \| TCRBV2S1	T cell receptor beta variable 2	Two-hybrid	BioGRID	16169070
TRDMT1	DNMT2 \| M.HsaIIP \| PuMet \| RNMT1	tRNA天冬氨酸甲基转移酶1	Two-hybrid	BioGRID	16169070
部落3	C20orf97 \|nipk \|水槽\|Skip3 \|TRB3	tribbles homolog 3 (Drosophila)	Two-hybrid	BioGRID	16169070
Trim28	FLJ29029 \|kap1 \|RNF96 \|TF1B \|tif1b	tripartite motif-containing 28	-	HPRD，Biogrid	11959841
TSC22D1	DKFZp686O19206 \| MGC17597 \| RP11-269C23.2 \| TGFB1I4 \| TSC22	TSC22域家庭，成员1	Two-hybrid	BioGRID	16169070
TTR	HST2651 \|palb \|TBPA	经硫代蛋白	Two-hybrid	BioGRID	16169070
TXNDC9	apacd	硫氧还蛋白域包含9个	Two-hybrid	BioGRID	16169070
ULK2	KIAA0623 \| Unc51.2	UNC-51样激酶2（秀丽隐杆线虫）	Two-hybrid	BioGRID	16169070
USP11	UHX1	泛素特异性肽酶11	Two-hybrid	BioGRID	16169070
ZFP64	MGC940 \|ZNF338	锌指蛋白64同源物（小鼠）	Two-hybrid	BioGRID	16169070
ZNF24	KOX17 \| RSG-A \| ZNF191 \| ZSCAN3 \| Zfp191	zinc finger protein 24	Two-hybrid	BioGRID	16169070

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG LYSINE DEGRADATION	44	29	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
Ginestier乳腺癌Znf217扩增DN	335	193	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
洛克伍德在肺癌中放大	214	139	All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞QTL Trans	882	572	All SZGR 2.0 genes in this pathway
Kamminga EZH2目标	41	26	All SZGR 2.0 genes in this pathway
Nouzova维甲酸和H4乙酰化	143	85	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN	60	45	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
由Foxp3绑定的Marson未刺激	1229	713	All SZGR 2.0 genes in this pathway
林黑色素瘤复制号码	73	53	All SZGR 2.0 genes in this pathway
Chen Hoxa5靶向9小时	223	132	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
Boyault肝癌子类G1 UP	113	70	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP	344	215	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR	152	88	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
mir-28	107	114	1A,m8	HSA-MIR-28^脑	AAGGAGCUCACAGUCUAUUGAG
mir-29	159	166	1A,m8	hsa-miR-29a^SZ	uagcaccaucugaaaucgguu
				hsa-miR-29b^SZ	uagcaccauuugaaaucaguguu
				hsa-miR-29c^SZ	uagcaccauuugaaaucggu

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：setDB1