Gene Page:cdc5l

概括?
基因 988
Symbol cdc5l
Synonyms CDC5|CDC5-LIKE|CEF1|PCDC5RP|dJ319D22.1
Description cell division cycle 5 like
Reference MIM:602868|HGNC:HGNC:1743|Ensembl:ENSG00000096401|HPRD:04184|Vega:OTTHUMG00000014767
Gene type protein-coding
Map location 6p21
Pascal p-value 0.261
Sherlock p-value 0.345
Fetal beta 1.339
DMG 1 (# studies)
eGene Myers' cis & trans
元

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0114

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg15773716 6 44355950 cdc5l 1.84E-5 -0.36 0.016 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2207105 chr20 11231352 cdc5l 988 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHEK1 0.93 0.79
TIMELESS 0.92 0.81
GINS1 0.91 0.80
DEPDC1B 0.91 0.78
MCM2 0.91 0.84
GINS2 0.91 0.73
FBXO5 0.91 0.81
DTL 0.90 0.80
wee1 0.90 0.80
RRM1 0.90 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.55 -0.74
HLA-F -0.54 -0.71
AF347015.27 -0.51 -0.78
PTH1R -0.51 -0.66
ASPHD1 -0.51 -0.57
FBXO2 -0.51 -0.59
AF347015.31 -0.51 -0.77
CA4 -0.51 -0.69
SLC16A11 -0.50 -0.61
MT-CO2 -0.50 -0.79

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding NAS 8917598
GO:0003723 RNA binding IEA -
GO:0005515 protein binding 新闻学会 15232106|17353931
Biological process 去的术语 Evidence Neuro keywords PubMed ID
去：0006355 regulation of transcription, DNA-dependent NAS -
GO:0006397 mRNA processing IEA -
GO:0008380 RNA splicing IEA -
GO:0007049 cell cycle IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus NAS -
GO:0005681 spliceosome IEA -
GO:0005730 nucleolus IDA 18029348
GO:0005737 cytoplasm IEA -
GO:0016607 nuclear speck IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SPLICEOSOME 128 72 该途径中的所有SZGR 2.0基因
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 该途径中的所有SZGR 2.0基因
THUM SYSTOLIC HEART FAILURE UP 423 283 该途径中的所有SZGR 2.0基因
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 该途径中的所有SZGR 2.0基因
OSMAN BLADDER CANCER UP 404 246 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 6HR UP 55 34 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 该途径中的所有SZGR 2.0基因
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
HAMAI APOPTOSIS VIA TRAIL UP 584 356 该途径中的所有SZGR 2.0基因
XU AKT1 TARGETS 6HR 27 18 该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 20HR UP 240 152 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 16HR UP 225 139 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 该途径中的所有SZGR 2.0基因
JIANG AGING CEREBRAL CORTEX UP 36 27 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
YAMAZAKI TCEB3 TARGETS DN 215 132 该途径中的所有SZGR 2.0基因
MA PITUITARY FETAL VS ADULT UP 29 21 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 18HR UP 178 111 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 24HR UP 148 96 该途径中的所有SZGR 2.0基因
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER UP 973 570 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL UP 648 398 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS UP 198 128 该途径中的所有SZGR 2.0基因
ICHIBA GRAFT VERSUS HOST DISEASE D7 DN 40 22 该途径中的所有SZGR 2.0基因
Han Satb1靶向 395 249 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 该途径中的所有SZGR 2.0基因
冈本肝癌多中心发生 25 15 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 2 DN 336 211 该途径中的所有SZGR 2.0基因
PASINI SUZ12 TARGETS UP 112 65 该途径中的所有SZGR 2.0基因
YU BAP1 TARGETS 29 21 该途径中的所有SZGR 2.0基因
RAO BOUND BY SALL4 ISOFORM A 182 108 该途径中的所有SZGR 2.0基因
山乳房干细胞DN 146 88 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-186 213 219 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU