Gene Page:SEPT7

Summary?
GeneID 989
Symbol SEPT7
Synonyms CDC10|CDC3|NBLA02942|SEPT7A
Description septin 7
Reference MIM:603151|HGNC:HGNC:1717|Ensembl:ENSG00000122545|HPRD:04398|Vega:OTTHUMG00000155063
Gene type protein-coding
Map location 7p14.2
帕斯卡p-value 0.057
Sherlock p-value 0.46
DMG 1 (# studies)
eGene Myers' cis & trans
Support PROTEIN CLUSTERING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_mGluR5
G2Cdb.human_Synaptosome
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统的搜索在酒吧Med for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21815536 7 35840623 SEPT7 2.979E-4 -0.216 0.039 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9882137 chr3 29494146 SEPT7 989 0.03 trans
rs9882501 chr3 29494429 SEPT7 989 0.1 trans
rs4491879 chr3 189373908 SEPT7 989 0.1 trans
rs4505678 chr3 189374356 SEPT7 989 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
WDR62 0.83 0.73
RAD54L 0.81 0.57
E2F1 0.81 0.78
SPAG5 0.80 0.63
GSX2 0.80 0.23
NCAPD2 0.79 0.55
NOTCH1 0.79 0.56
SALL1 0.79 0.69
CDT1 0.79 0.46
MCM3 0.79 0.68
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.35 -0.30
AF347015.31 -0.31 -0.25
IL32 -0.30 -0.34
AF347015.8 -0.30 -0.23
AF347015.18 -0.30 -0.25
MT-CO2 -0.30 -0.23
SYCP3 -0.29 -0.33
C1orf54 -0.28 -0.26
MT-ATP8 -0.28 -0.23
MT-CYB -0.27 -0.20

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 15485874
GO:0005525 三磷酸鸟苷结合 IEA -
GO:0005525 三磷酸鸟苷结合 TAS 8037772
GO:0005198 structural molecule activity TAS 8037772
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000910 cytokinesis TAS 8037772
GO:0007049 cell cycle IEA -
GO:0051291 protein heterooligomerization IDA 15485874
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0019717 synaptosome IEA Synap, Brain (GO term level: 7) -
GO:0001725 stress fiber IDA 15485874
GO:0005634 nucleus IDA 15485874
GO:0031105 septin complex IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WATANABE COLON CANCER MSI VS MSS DN 81 42 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 38 27 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS RESISTANT DN 5 5 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 103 64 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
STONER ESOPHAGEAL CARCINOGENESIS UP 39 25 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 37 31 All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP 29 21 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 54 43 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS UP 10 8 All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS CANCER UP 31 23 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP 33 19 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 43 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR UP 17 10 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-127 67 73 m8 hsa-miR-127brain UCGGAUCCGUCUGAGCUUGGCU
miR-141/200a 56 62 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-149 630 636 1A hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-182 32 38 m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-183 369 375 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-186 590 597 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 83 89 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-216 155 161 1A hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-219 288 294 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-24* 819 825 1A hsa-miR-189 GUGCCUACUGAGCUGAUAUCAGU
miR-30-5p 312 319 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-325 879 885 1A hsa-miR-325 CCUAGUAGGUGUCCAGUAAGUGU
miR-33 262 268 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-335 901 907 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-376 397 403 m8 hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-452 382 388 m8 hsa-miR-452 UGUUUGCAGAGGAAACUGAGAC
miR-493-5p 285 291 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-495 575 581 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU