Gene Page:TELO2

Summary?
GeneID 9894
Symbol TELO2
Synonyms CLK2|TEL2
Description telomere maintenance 2
Reference MIM:611140|HGNC:HGNC:29099|Ensembl:ENSG00000100726|HPRD:10016|Vega:OTTHUMG00000044471
Gene type protein-coding
Map location 16p13.3
Pascal p-value 0.972
Sherlock p-value 0.376
Fetal beta -0.035
DMG 1 (# studies)
eGene Cortex
Frontal Cortex BA9
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08699794 16 1557513 TELO2 4.268E-4 0.41 0.045 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 TELO2 9894 0.02 trans
rs16955618 chr15 29937543 TELO2 9894 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TNK2 0.79 0.78
SLC6A8 0.79 0.77
PYCR2 0.79 0.80
ALAD 0.78 0.75
SLC48A1 0.78 0.79
BDH1 0.78 0.81
AGFG2 0.77 0.79
PDK2 0.77 0.70
PNPO 0.76 0.75
DHRS11 0.76 0.74
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
YBX1 -0.48 -0.49
CCDC112 -0.48 -0.38
RBMX2 -0.48 -0.50
KCNRG -0.47 -0.36
AC016138.1 -0.47 -0.45
IDH1 -0.47 -0.39
PHF14 -0.47 -0.48
C11orf57 -0.47 -0.48
TTC27 -0.47 -0.38
SQLE -0.47 -0.39

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16P13 AMPLICON 120 49 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
LIN APC TARGETS 77 55 All SZGR 2.0 genes in this pathway
GALE APL WITH FLT3 MUTATED UP 56 35 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217 138 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway