Gene Page:SUPT7L

Summary?
GeneID 9913
Symbol SUPT7L
Synonyms SPT7L|STAF65|STAF65(gamma)|STAF65G|SUPT7H
Description SPT7-like STAGA complex gamma subunit
Reference MIM:612762|HGNC:HGNC:30632|Ensembl:ENSG00000119760|HPRD:18115|Vega:OTTHUMG00000151947
Gene type protein-coding
Map location 2p23.3
Pascal p-value 0.002
Fetal beta -0.229
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09131135 2 27886635 SUPT7L -0.022 0.77 DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DUS1L 0.77 0.78
ABCF3 0.76 0.70
KAT2A 0.75 0.71
MAN2C1 0.75 0.75
TPCN2 0.75 0.77
CD3EAP 0.75 0.76
AMDHD2 0.74 0.77
PHF1 0.74 0.73
AC008806.1 0.74 0.73
RHOT2 0.74 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.51 -0.31
AF347015.18 -0.48 -0.29
AF347015.8 -0.45 -0.26
MT-ATP8 -0.44 -0.31
AF347015.2 -0.44 -0.26
IL32 -0.43 -0.31
MT-CO2 -0.43 -0.25
AF347015.31 -0.42 -0.27
GNG11 -0.42 -0.36
NOSTRIN -0.41 -0.24

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID MYC ACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 25 22 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
NAGY TFTC COMPONENTS HUMAN 19 11 All SZGR 2.0 genes in this pathway
NAGY STAGA COMPONENTS HUMAN 15 8 All SZGR 2.0 genes in this pathway
LASTOWSKA COAMPLIFIED WITH MYCN 43 29 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 162 86 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS DN 53 29 All SZGR 2.0 genes in this pathway