Gene Page:ZBTB40

Summary?
GeneID 9923
Symbol ZBTB40
Synonyms ZNF923
Description zinc finger and BTB domain containing 40
Reference MIM:612106|HGNC:HGNC:29045|Ensembl:ENSG00000184677|HPRD:11086|Vega:OTTHUMG00000002897
Gene type protein-coding
Map location 1p36
Pascal p-value 0.808
Sherlock p-value 0.862
Fetal beta 1.161
eGene Myers' cis & trans
元
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis 新创4基因的突变是鉴别ified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
ZBTB40 chr1 22850725 C T NM_001083621
NM_014870		 p.1105R>W
p.1105R>W		 missense
missense		 Schizophrenia DNM:Xu_2012

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16826595 chr1 22425861 ZBTB40 9923 0.02 cis
rs10915848 chr1 225788919 ZBTB40 9923 0.18 trans
rs7584986 chr2 184111432 ZBTB40 9923 0.01 trans
rs1155107 chr3 26843376 ZBTB40 9923 0.11 trans
rs17029291 chr3 32402138 ZBTB40 9923 0.01 trans
rs6771817 chr3 165557099 ZBTB40 9923 0.14 trans
rs830202 chr3 165654796 ZBTB40 9923 0.04 trans
rs17415971 chr4 14272434 ZBTB40 9923 0.15 trans
rs4645225 chr4 126010830 ZBTB40 9923 0.14 trans
rs6882818 chr5 55987580 ZBTB40 9923 0.03 trans
rs1432030 chr8 133175445 ZBTB40 9923 0.08 trans
rs7894597 chr10 9384581 ZBTB40 9923 0 trans
rs7076439 chr10 93286841 ZBTB40 9923 0.06 trans
rs11186601 chr10 93287199 ZBTB40 9923 0.01 trans
rs1324669 chr13 107872446 ZBTB40 9923 3.155E-4 trans
rs16958358 chr17 55502410 ZBTB40 9923 0.17 trans
rs6098023 chr20 53113740 ZBTB40 9923 0.03 trans
rs17145698 chrX 40218345 ZBTB40 9923 0 trans
rs17264923 chrX 69499164 ZBTB40 9923 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC25A28 0.61 0.61
TYK2 0.61 0.61
MAN2C1 0.60 0.61
AGXT2L2 0.60 0.60
TMEM129 0.60 0.58
RECQL5 0.58 0.60
ANGEL1 0.57 0.60
SLC39A13 0.57 0.59
PNPLA2 0.57 0.58
TMEM175 0.56 0.57
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SEC62 -0.35 -0.38
GNG11 -0.31 -0.32
RP11-3P17.1 -0.30 -0.33
SNRPG -0.29 -0.31
FAM159B -0.29 -0.40
SPINK8 -0.28 -0.30
AC011475.1 -0.28 -0.32
EIF3J -0.28 -0.21
AC051635.1 -0.27 -0.26
AC108145.1 -0.27 -0.25

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WATTEL AUTONOMOUS THYROID ADENOMA UP 73 47 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159 105 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 167 99 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway